Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
Name | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 |
---|---|
Synonyms | 1.14.11.- ABH3 Alkylated DNA repair protein alkB homolog 3 DEPC-1 DEPC1 Prostate cancer antigen 1 |
Gene Name | ALKBH3 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0004343|Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 MEEKRRRARVQGAWAAPVKSQAIAQPATTAKSHLHQKPGQTWKNKEHHLSDREFVFKEPQ QVVRRAPEPRVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLCQDVPWKQRTG IREDITYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNSLLCNL YRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRTFEMRKKPPPEENGDYTYVERVKIPLD HGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRTVYPDPRGAPW |
Number of residues | 286 |
Molecular Weight | 33374.495 |
Theoretical pI | 8.58 |
GO Classification |
Functions
L-ascorbic acid binding cytosine C-5 DNA demethylase activity DNA-N1-methyladenine dioxygenase activity ferrous iron binding Processes
cell proliferation DNA dealkylation involved in DNA repair oxidative single-stranded DNA demethylation DNA repair Components
nucleoplasm cytoplasm mitochondrion nucleus |
General Function | L-ascorbic acid binding |
Specific Function | Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron. |
Transmembrane Regions | |
GenBank Protein ID | 16326129 |
UniProtKB ID | Q96Q83 |
UniProtKB Entry Name | ALKB3_HUMAN |
Cellular Location | Cytoplasm |
Gene sequence | >lcl|BSEQ0011598|Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (ALKBH3) ATGGAGGAAAAAAGACGGCGAGCCCGAGTTCAGGGAGCCTGGGCTGCCCCTGTTAAAAGC CAGGCCATTGCTCAGCCAGCTACCACTGCTAAGAGCCATCTCCACCAGAAGCCTGGCCAG ACCTGGAAGAACAAAGAGCATCATCTCTCTGACAGAGAGTTTGTGTTCAAAGAACCTCAG CAGGTAGTACGTAGAGCTCCTGAGCCACGAGTGATTGACAGAGAGGGTGTGTATGAAATC AGCCTGTCACCCACAGGTGTATCTAGGGTCTGTTTGTATCCTGGCTTTGTTGACGTGAAA GAAGCTGACTGGATATTGGAACAGCTTTGTCAAGATGTTCCCTGGAAACAGAGGACCGGC ATCAGAGAGGATATAACTTATCAGCAACCAAGACTTACAGCATGGTATGGAGAACTTCCT TACACTTATTCAAGAATCACTATGGAACCAAATCCTCACTGGCACCCTGTGCTGCGCACA CTAAAGAACCGCATTGAAGAGAACACTGGCCACACCTTCAACTCCTTACTCTGCAATCTT TATCGCAATGAGAAGGACAGCGTGGACTGGCACAGTGATGATGAACCCTCACTAGGGAGG TGCCCCATTATTGCTTCACTAAGTTTTGGTGCCACACGCACATTTGAGATGAGAAAGAAG CCACCACCAGAAGAGAATGGAGACTACACATATGTGGAAAGAGTGAAGATACCCTTGGAT CATGGGACCTTGTTAATCATGGAAGGAGCGACACAAGCTGACTGGCAGCATCGAGTGCCC AAAGAATACCACTCTAGAGAACCGAGAGTGAACCTGACCTTTCGGACAGTCTATCCAGAC CCTCGAGGGGCACCCTGGTGA |
GenBank Gene ID | AB042029 |
GeneCard ID | None |
GenAtlas ID | ALKBH3 |
HGNC ID | HGNC:30141 |
Chromosome Location | 11 |
Locus | 11p11.2 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Nickel |
58.693 |
||
Nickel chloride |
129.593 |
||
Nickelocene |
188.883 |