Histone H2A type 1-A

NameHistone H2A type 1-A
SynonymsH2AFR Histone H2A/r
Gene NameHIST1H2AA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017628|Histone H2A type 1-A
MSGRGKQGGKARAKSKSRSSRAGLQFPVGRIHRLLRKGNYAERIGAGAPVYLAAVLEYLT
AEILELAGNASRDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK
TESHHHKAQSK
Number of residues131
Molecular Weight14233.39
Theoretical pINone
GO Classification
Functions
    DNA binding
Processes
    chromatin silencing
chromatin organization
Components
    nucleus
extracellular exosome
nuclear chromatin
nuclear chromosome, telomeric region
nucleosome
General FunctionDna binding
Specific FunctionCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ96QV6
UniProtKB Entry NameH2A1A_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0017629|Histone H2A type 1-A (HIST1H2AA)
ATGTCTGGACGAGGGAAGCAGGGAGGAAAAGCACGCGCCAAGTCTAAGTCTCGCTCTTCT
AGAGCGGGTTTGCAGTTTCCCGTAGGCCGGATCCATCGTCTGCTTCGTAAGGGAAACTAT
GCAGAGCGGATAGGGGCAGGCGCACCAGTGTATTTGGCGGCAGTGTTAGAGTATCTCACA
GCAGAAATCCTTGAGCTGGCAGGCAATGCGTCTCGCGATAACAAAAAAACTCGCATTATT
CCCCGCCACCTGCAGCTAGCGATCCGCAATGATGAGGAACTCAATAAGCTTTTGGGCGGC
GTGACCATTGCCCAGGGCGGAGTCCTGCCTAACATTCAGGCAGTGCTGCTGCCCAAGAAG
ACTGAGAGTCACCACCATAAAGCCCAAAGCAAGTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:18729
Chromosome Location6
LocusNone
References
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