G-protein coupled estrogen receptor 1

NameG-protein coupled estrogen receptor 1
SynonymsCEPR Chemoattractant receptor-like 2 CMKRL2 DRY12 FEG-1 Flow-induced endothelial G-protein coupled receptor 1 G protein-coupled estrogen receptor 1 G-protein coupled receptor 30 GPCR-Br GPER GPR30 IL8-related receptor DRY12 LYGPR Lymphocyte-derived G-protein coupled receptor Membrane estrogen receptor mER
Gene NameGPER1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0020690|G-protein coupled estrogen receptor 1
MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLF
LSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLH
ERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGL
IWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRV
LVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRH
AHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVI
PDSTEQSDVRFSSAV
Number of residues375
Molecular Weight42247.12
Theoretical pI8.36
GO Classification
Functions
    chromatin binding
steroid hormone binding
drug binding
G-protein coupled receptor activity
estrogen receptor activity
steroid binding
mineralocorticoid receptor activity
Processes
    positive regulation of uterine smooth muscle contraction
intracellular steroid hormone receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
negative regulation of cell cycle process
cytosolic calcium ion homeostasis
negative regulation of ERK1 and ERK2 cascade
neuronal action potential
cellular response to mineralocorticoid stimulus
positive regulation of protein phosphorylation
positive regulation of inositol trisphosphate biosynthetic process
negative regulation of DNA metabolic process
positive regulation of cell proliferation
cellular response to peptide hormone stimulus
inflammatory response
positive regulation of ERK1 and ERK2 cascade
negative regulation of leukocyte activation
positive regulation of phosphatidylinositol 3-kinase signaling
negative regulation of cell cycle arrest
cell cycle
negative regulation of fat cell differentiation
cellular response to tumor necrosis factor
positive regulation of insulin secretion
negative regulation of lipid biosynthetic process
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of gene expression
positive regulation of endothelial cell apoptotic process
positive regulation of cell migration
positive regulation of vasodilation
negative regulation of vascular smooth muscle cell proliferation
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
negative regulation of protein kinase B signaling
negative regulation of gene expression
steroid hormone mediated signaling pathway
negative regulation of cell proliferation
cellular response to estradiol stimulus
nuclear fragmentation involved in apoptotic nuclear change
apoptotic chromosome condensation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cardiac vascular smooth muscle cell differentiation
negative regulation of inflammatory response
positive regulation of establishment of protein localization to plasma membrane
positive regulation of MAPK cascade
positive regulation of neurotransmitter secretion
positive regulation of cAMP biosynthetic process
positive regulation of extrinsic apoptotic signaling pathway
positive regulation of neurogenesis
innate immune response
positive regulation of epidermal growth factor receptor signaling pathway
cellular response to glucose stimulus
positive regulation of G-protein coupled receptor protein signaling pathway
positive regulation of apoptotic process
positive regulation of release of cytochrome c from mitochondria
G-protein coupled receptor signaling pathway
mineralocorticoid receptor signaling pathway
Components
    nuclear envelope
axon
endoplasmic reticulum membrane
integral component of plasma membrane
early endosome
presynaptic membrane
intracellular
dendritic shaft
mitochondrial membrane
cytoplasm
cell junction
postsynaptic density
keratin filament
Golgi apparatus
presynaptic active zone
nucleus
cytosol
Golgi membrane
trans-Golgi network
perinuclear region of cytoplasm
cytoplasmic vesicle membrane
axon terminus
dendritic spine head
dendritic spine membrane
endoplasmic reticulum
recycling endosome
dendrite
plasma membrane
neuronal postsynaptic density
General FunctionSteroid hormone binding
Specific FunctionG-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.
Transmembrane Regions63-84 97-120 133-153 176-194 221-236 260-280 307-327
GenBank Protein ID
UniProtKB IDQ99527
UniProtKB Entry NameGPER1_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0020691|G-protein coupled estrogen receptor 1 (GPER1)
ATGGATGTGACTTCCCAAGCCCGGGGCGTGGGCCTGGAGATGTACCCAGGCACCGCGCAG
CCTGCGGCCCCCAACACCACCTCCCCCGAGCTCAACCTGTCCCACCCGCTCCTGGGCACC
GCCCTGGCCAATGGGACAGGTGAGCTCTCGGAGCACCAGCAGTACGTGATCGGCCTGTTC
CTCTCGTGCCTCTACACCATCTTCCTCTTCCCCATCGGCTTTGTGGGCAACATCCTGATC
CTGGTGGTGAACATCAGCTTCCGCGAGAAGATGACCATCCCCGACCTGTACTTCATCAAC
CTGGCGGTGGCGGACCTCATCCTGGTGGCCGACTCCCTCATTGAGGTGTTCAACCTGCAC
GAGCGGTACTACGACATCGCCGTCCTGTGCACCTTCATGTCGCTCTTCCTGCAGGTCAAC
ATGTACAGCAGCGTCTTCTTCCTCACCTGGATGAGCTTCGACCGCTACATCGCCCTGGCC
AGGGCCATGCGCTGCAGCCTGTTCCGCACCAAGCACCACGCCCGGCTGAGCTGTGGCCTC
ATCTGGATGGCATCCGTGTCAGCCACGCTGGTGCCCTTCACCGCCGTGCACCTGCAGCAC
ACCGACGAGGCCTGCTTCTGTTTCGCGGATGTCCGGGAGGTGCAGTGGCTCGAGGTCACG
CTGGGCTTCATCGTGCCCTTCGCCATCATCGGCCTGTGCTACTCCCTCATTGTCCGGGTG
CTGGTCAGGGCGCACCGGCACCGTGGGCTGCGGCCCCGGCGGCAGAAGGCGCTCCGCATG
ATCCTCGCGGTGGTGCTGGTCTTCTTCGTCTGCTGGCTGCCGGAGAACGTCTTCATCAGC
GTGCACCTCCTGCAGCGGACGCAGCCTGGGGCCGCTCCCTGCAAGCAGTCTTTCCGCCAT
GCCCACCCCCTCACGGGCCACATTGTCAACCTCGCCGCCTTCTCCAACAGCTGCCTAAAC
CCCCTCATCTACAGCTTTCTCGGGGAGACCTTCAGGGACAAGCTGAGGCTGTACATTGAG
CAGAAAACAAATTTGCCGGCCCTGAACCGCTTCTGTCACGCTGCCCTGAAGGCCGTCATT
CCAGACAGCACCGAGCAGTCGGATGTGAGGTTCAGCAGTGCCGTGTAG
GenBank Gene IDBC011634
GeneCard IDNone
GenAtlas IDGPER
HGNC IDHGNC:4485
Chromosome Location7
LocusNone
References
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