P2X purinoceptor 4


NameP2X purinoceptor 4
SynonymsATP receptor P2X4 Purinergic receptor
Gene NameP2RX4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009820|P2X purinoceptor 4
MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSV
VSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIP
DATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLK
AAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAG
HSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYY
RDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYC
MKKRLYYREKKYKYVEDYEQGLASELDQ
Number of residues388
Molecular Weight43368.725
Theoretical pINone
GO Classification
Functions
    ATP binding
    copper ion binding
    receptor binding
    cadherin binding
    drug binding
    protein homodimerization activity
    zinc ion binding
    extracellular ATP-gated cation channel activity
    purinergic nucleotide receptor activity
Processes
    signal transduction
    nitric oxide biosynthetic process
    ion transmembrane transport
    endothelial cell activation
    regulation of cardiac muscle contraction
    negative regulation of cardiac muscle hypertrophy
    regulation of blood pressure
    positive regulation of nitric oxide biosynthetic process
    sensory perception of pain
    apoptotic signaling pathway
    positive regulation of calcium ion transport
    cellular response to ATP
    protein homooligomerization
    relaxation of cardiac muscle
    vasodilation
    positive regulation of calcium ion transport into cytosol
    membrane depolarization
    transport
    excitatory postsynaptic potential
    neuronal action potential
    regulation of sodium ion transport
    response to fluid shear stress
    calcium ion transport
    response to ATP
    tissue homeostasis
    positive regulation of prostaglandin secretion
    positive regulation of calcium-mediated signaling
    purinergic nucleotide receptor signaling pathway
Components
    neuronal cell body
    apical part of cell
    postsynaptic density
    plasma membrane
    dendritic spine
    cell junction
    lysosomal membrane
    terminal bouton
    extracellular exosome
    integral component of nuclear inner membrane
    perinuclear region of cytoplasm
    integral component of plasma membrane
    membrane
General FunctionZinc ion binding
Specific FunctionReceptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.
Transmembrane Regions34-54 339-359
GenBank Protein ID
UniProtKB IDQ99571
UniProtKB Entry NameP2RX4_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0013934|P2X purinoceptor 4 (P2RX4)
ATGGCGGGCTGCTGCGCCGCGCTGGCGGCCTTCCTGTTCGAGTACGACACGCCGCGCATC
GTGCTCATCCGCAGCCGCAAAGTGGGGCTCATGAACCGCGCCGTGCAACTGCTCATCCTG
GCCTACGTCATCGGGTGCTACCATCCCCATTTGGCAGAAGTGGAAATGGAGTCCCCTAGA
AGGTGGGTGTTTGTGTGGGAAAAGGGCTACCAGGAAACTGACTCCGTGGTCAGCTCCGTT
ACGACCAAGGTCAAGGGCGTGGCTGTGACCAACACTTCTAAACTTGGATTCCGGATCTGG
GATGTGGCGGATTATGTGATACCAGCTCAGGAGGAAAACTCCCTCTTCGTCATGACCAAC
GTGATCCTCACCATGAACCAGACACAGGGCCTGTGCCCCGAGATTCCAGATGCGACCACT
GTGTGTAAATCAGATGCCAGCTGTACTGCCGGCTCTGCCGGCACCCACAGCAACGGAGTC
TCAACAGGCAGGTGCGTAGCTTTCAACGGGTCTGTCAAGACGTGTGAGGTGGCGGCCTGG
TGCCCGGTGGAGGATGACACACACGTGCCACAACCTGCTTTTTTAAAGGCTGCAGAAAAC
TTCACTCTTTTGGTTAAGAACAACATCTGGTATCCCAAATTTAATTTCAGCAAGAGGAAT
ATCCTTCCCAACATCACCACTACTTACCTCAAGTCGTGCATTTATGATGCTAAAACAGAT
CCCTTCTGCCCCATATTCCGTCTTGGCAAAATAGTGGAGAACGCAGGACACAGTTTCCAG
GACATGGCCGTGGAGGGAGGCATCATGGGCATCCAGGTCAACTGGGACTGCAACCTGGAC
AGAGCCGCCTCCCTCTGCTTGCCCAGGTACTCCTTCCGCCGCCTCGATACACGGGACGTT
GAGCACAACGTATCTCCTGGCTACAATTTCAGGTTTGCCAAGTACTACAGAGACCTGGCT
GGCAACGAGCAGCGCACGCTCATCAAGGCCTATGGCATCCGCTTCGACATCATTGTGTTT
GGGAAGGCAGGGAAATTTGACATCATCCCCACTATGATCAACATCGGCTCTGGCCTGGCA
CTGCTAGGCATGGCGACCGTGCTGTGTGACATCATAGTCCTCTACTGCATGAAGAAAAGA
CTCTACTATCGGGAGAAGAAATATAAATATGTGGAAGATTACGAGCAGGGTCTTGCTAGT
GAGCTGGACCAGTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:8535
Chromosome Location12
LocusNone
References
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  2. Garcia-Guzman M, Soto F, Gomez-Hernandez JM, Lund PE, Stuhmer W: Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. Mol Pharmacol. 1997 Jan;51(1):109-18.[9016352 ]
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