Gamma-aminobutyric acid receptor subunit gamma-3

NameGamma-aminobutyric acid receptor subunit gamma-3
SynonymsGABA(A) receptor subunit gamma-3
Gene NameGABRG3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0006921|Gamma-aminobutyric acid receptor subunit gamma-3
MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDK
KLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNS
NMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPM
DEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDY
VVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLS
TIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDS
SRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCC
YEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLLFNLVYWVGYLYL
Number of residues467
Molecular Weight54288.16
Theoretical pI7.58
GO Classification
Functions
    chloride channel activity
GABA-A receptor activity
inhibitory extracellular ligand-gated ion channel activity
Processes
    transmembrane transport
ion transmembrane transport
response to drug
chloride transmembrane transport
regulation of membrane potential
gamma-aminobutyric acid signaling pathway
neurological system process
synaptic transmission
Components
    integral component of plasma membrane
synapse
postsynaptic membrane
neuron projection
plasma membrane
chloride channel complex
GABA-A receptor complex
cell junction
General FunctionInhibitory extracellular ligand-gated ion channel activity
Specific FunctionGABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Transmembrane Regions255-277 281-303 315-337 444-467
GenBank Protein ID1754749
UniProtKB IDQ99928
UniProtKB Entry NameGBRG3_HUMAN
Cellular LocationCell junction
Gene sequence
>lcl|BSEQ0012498|Gamma-aminobutyric acid receptor subunit gamma-3 (GABRG3)
ATGGCCCCGAAGCTGCTGCTCCTCCTCTGCCTGTTCTCGGGCTTGCACGCGCGGTCCAGA
AAGGTGGAAGAGGATGAATATGAAGATTCATCATCAAACCAAAAGTGGGTCTTGGCTCCA
AAATCCCAAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAA
AAGCTGAGGCCAGATATTGGAATAAAACCGACCGTAATTGACGTTGACATTTATGTTAAC
AGCATTGGTCCTGTGTCATCAATAAACATGGAATACCAAATTGACATATTTTTTGCTCAG
ACCTGGACAGATAGTCGCCTTCGATTCAACAGCACAATGAAAATTCTTACTCTGAACAGC
AACATGGTGGGGTTAATCTGGATCCCAGACACCATCTTCCGCAATTCTAAAACCGCAGAG
GCTCACTGGATCACCACACCCAATCAGCTCCTCCGGATTTGGAATGACGGGAAAATCCTT
TACACTTTGAGGCTCACCATCAATGCTGAGTGCCAGCTGCAGCTGCACAACTTCCCCATG
GACGAACACTCCTGCCCGCTGATTTTCTCCAGCTATGGCTATCCCAAAGAAGAAATGATT
TATAGATGGAGAAAAAATTCAGTGGAGGCAGCTGACCAGAAATCATGGCGGCTTTATCAG
TTTGACTTCATGGGCCTCAGAAACACCACAGAAATCGTGACAACGTCTGCAGGTAGGAAT
TTACTGAAAGAGGCACAGCTCTCAAAAGCCAGAGAGGCCTAA
GenBank Gene IDS82769
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:4088
Chromosome Location15
Locus15q12
References
  1. Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L 3rd, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C: Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 2006 Mar 30;440(7084):671-5.[16572171 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]
  3. Hadingham KL, Wafford KA, Thompson SA, Palmer KJ, Whiting PJ: Expression and pharmacology of human GABAA receptors containing gamma 3 subunits. Eur J Pharmacol. 1995 Nov 30;291(3):301-9.[8719414 ]

Related FRC

FRCD ID Name Exact Mass Structure




F04687



Muscimol hydrobromide


195.016




F04789



Anisatin


328.317




F04791



Cicutoxin


258.361




F04797



Oenanthotoxin


258.361




F04973



Aflatrem


501.667




F04979



Penitrem A


634.21




F04980



Penitrem B


583.769




F04981



Penitrem C


602.212




F04987



Fumitremorgin A


579.694




F04988



Fumitremorgin B


479.577




F04989



Fumitremorgin C


379.46




F05005



Janthitrem B


585.785




F05006



Janthitrem C


569.786




F05007



Janthitrem E


603.8




F05008



Janthitrem F


645.837




F05009



Janthitrem G


629.838




F05018



Paspalicine


417.549




F05019



Paxilline


435.564




F05020



Verrucosidin


416.514




F05021



Verruculogen


511.575




F05465



Lormetazepam


335.184




F03281



Dieldrin


380.895




F03344



1,1,1-Trichloroethane


133.396




F03388



1,1,2,2-Tetrachloroethane


167.838




F03400



Hexachlorocyclopentadiene


272.755




F03917



Mirex


545.51




F04769



Diazepam


284.74




F04993



Paspalinine


433.548




F05017



Paspalitrem A


501.667




F03275



Chloroform


119.369




F03276



Clofenotane


354.476




F03280



Trichloroethylene


131.38




F03283



Chlordane


409.758




F03285



Hexachlorobutadiene


260.744




F03291



Toxaphene


411.774




F03293



Tetrachloroethylene


165.822




F03294



Heptachlor


373.3




F03299



3,3'-Dichlorobenzidine


253.126




F03300



Endrin


380.895




F03303



Pentachlorophenol


266.323




F03324



Toluene


92.141




F03332



1,1-Dichloroethene


96.938




F03336



1,2-Dichloroethane


98.954




F03337



2,4,6-Trichlorophenol


197.439




F03341



Hexachlorobenzene


284.766




F03349



Chlorobenzene


112.556




F03360



1,2,3-Trichlorobenzene


181.44




F03370



Chlorpyrifos


350.575




F03381



Chlordecone


490.609




F03386



Dicofol


370.475




F03395



1,4-Dichlorobenzene


146.998




F03396



1,1-Dichloroethane


98.954




F03405



1,2-Dichlorobenzene


146.998




F03424



1,2,4-Trichlorobenzene


181.44




F03756



Methiochlor


377.766




F03757



Chlorbenzylate


325.185




F03879



Ethanol


46.07




F03886



1,3,5-Trichlorobenzene


181.44




F03890



Fipronil


437.141




F04038



Telodrin


411.73




F04039



Isodrin


364.896