S-methylmethionine--homocysteine S-methyltransferase BHMT2

NameS-methylmethionine--homocysteine S-methyltransferase BHMT2
Synonyms2.1.1.10 Betaine--homocysteine S-methyltransferase 2 SMM-hcy methyltransferase
Gene NameBHMT2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004414|S-methylmethionine--homocysteine S-methyltransferase BHMT2
MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVIEHPDAVRQLH
MEFLRAGSNVMQTFTFSASEDNMESKWEDVNAAACDLAREVAGKGDALVAGGICQTSIYK
YQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRPVAVTMCIGP
EGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPL
GFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRA
IAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASGRPFCPSLSK
PDF
Number of residues363
Molecular Weight40353.84
Theoretical pI5.68
GO Classification
Functions
    S-adenosylmethionine-homocysteine S-methyltransferase activity
S-methylmethionine-homocysteine S-methyltransferase activity
zinc ion binding
Processes
    S-adenosylmethionine metabolic process
sulfur amino acid metabolic process
L-methionine salvage
S-methylmethionine cycle
S-methylmethionine metabolic process
cellular nitrogen compound metabolic process
small molecule metabolic process
Components
    cytosol
extracellular exosome
General FunctionZinc ion binding
Specific FunctionInvolved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor.
Transmembrane Regions
GenBank Protein ID11907831
UniProtKB IDQ9H2M3
UniProtKB Entry NameBHMT2_HUMAN
Cellular Location
Gene sequence
>lcl|BSEQ0011622|S-methylmethionine--homocysteine S-methyltransferase BHMT2 (BHMT2)
ATGGCACCTGCTGGACGCCCGGGGGCCAAGAAGGGGATTTTGGAGCGCCTGGAGAGTGGG
GAGGTTGTGATTGGAGATGGCAGCTTTCTCATTACTCTGGAGAAGAGAGGCTATGTGAAG
GCTGGGCTCTGGACTCCAGAGGCAGTGATAGAACACCCAGACGCAGTTCGTCAACTTCAC
ATGGAATTCTTGAGAGCAGGATCAAATGTCATGCAGACTTTTACCTTTTCTGCCAGTGAG
GACAATATGGAAAGCAAGTATTTTGAGCACGTTGAAGAAGCTGTGTGGGCTGTGGAAGTC
TTAAAAGAATCAGATAGACCCGTGGCAGTTACCATGTGCATAGGCCCAGAGGGAGACATG
CATGATATAACCCCCGGAGAATGTGCTGTGAGGCTGGTGAAGGCAGGGGCTTCCATCGTT
GGCGTGAACTGCCGCTTTGGGCCCGACACCAGCTTGAAGACGATGGAGCTCATGAAGGAG
GGTCTTGAGTGGGCAGGGCTGAAAGCGCACCTCATGGTGCAGCCTCTGGGGTTCCACGCG
CCTGACTGTGGCAAAGAGGGGTTTGTGGATCTCCCAGAATATCCCTTTGGACTGGAGTCC
AGAGTTGCCACCAGATGGGATATTCAAAAATACGCCAGAGAGGCCTACAACCTGGGGGTC
AGGTACATTGGCGGGTGCTGTGGATTTGAGCCCTACCACATCAGGGCAATTGCAGAGGAG
CTGGCCCCAGAAAGGGGCTTTTTGCCACCAGCTTCAGAAAAACACGGCAGCTGGGGAAGT
GGTTTGGACATGCACACCAAACCCTGGATTAGAGCAAGGGCTCGAAGGGAGTATTGGGAG
AATCTGCTGCCAGCTTCAGGCAGACCTTTCTGTCCTTCGCTGTCAAAGCCAGACTTCTAA
GenBank Gene IDAF257473
GeneCard IDNone
GenAtlas IDBHMT2
HGNC IDHGNC:1048
Chromosome Location5
Locus5q13
References
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  2. Szegedi SS, Castro CC, Koutmos M, Garrow TA: Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase. J Biol Chem. 2008 Apr 4;283(14):8939-45. doi: 10.1074/jbc.M710449200. Epub 2008 Jan 29.[18230605 ]
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  4. Chadwick LH, McCandless SE, Silverman GL, Schwartz S, Westaway D, Nadeau JH: Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes. Genomics. 2000 Nov 15;70(1):66-73.[11087663 ]
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