Small conductance calcium-activated potassium channel protein 2
Name | Small conductance calcium-activated potassium channel protein 2 |
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Synonyms | KCa2.2 SK2 |
Gene Name | KCNN2 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0008406|Small conductance calcium-activated potassium channel protein 2 MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVS SSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYK LGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTII LLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTAR LAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRF VMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIG YGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVK NAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLV DLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFI EAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS |
Number of residues | 579 |
Molecular Weight | 63759.03 |
Theoretical pI | 9.99 |
GO Classification |
Functions
protein homodimerization activity calmodulin binding calcium-activated potassium channel activity protein domain specific binding alpha-actinin binding small conductance calcium-activated potassium channel activity Processes
potassium ion transmembrane transport potassium ion transport synaptic transmission regulation of potassium ion transmembrane transport Components
integral component of membrane T-tubule Z disc plasma membrane neuronal cell body dendritic spine smooth endoplasmic reticulum cell surface |
General Function | Small conductance calcium-activated potassium channel activity |
Specific Function | Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. |
Transmembrane Regions | 138-158 168-188 214-234 256-276 305-325 374-394 |
GenBank Protein ID | 10334701 |
UniProtKB ID | Q9H2S1 |
UniProtKB Entry Name | KCNN2_HUMAN |
Cellular Location | Membrane |
Gene sequence | >lcl|BSEQ0019569|Small conductance calcium-activated potassium channel protein 2 (KCNN2) ATGTGGTTGATATCAATAACTTTTCTCTCCATTGGTTATGGTGACATGGTACCTAACACA TACTGTGGAAAAGGAGTCTGCTTACTTACTGGAATTATGGGTGCTGGTTGCACAGCCCTG GTGGTAGCTGTAGTGGCAAGGAAGCTAGAACTTACCAAAGCAGAAAAACACGTGCACAAT TTCATGATGGATACTCAGCTGACTAAAAGAGTAAAAAATGCAGCTGCCAATGTACTCAGG GAAACATGGCTAATTTACAAAAATACAAAGCTAGTGAAAAAGATAGATCATGCAAAAGTA AGAAAACATCAACGAAAATTCCTGCAAGCTATTCATCAATTAAGAAGTGTAAAAATGGAG CAGAGGAAACTGAATGACCAAGCAAACACTTTGGTGGACTTGGCAAAGACCCAGAACATC ATGTATGATATGATTTCTGACTTAAACGAAAGGAGTGAAGACTTCGAGAAGAGGATTGTT ACCCTGGAAACAAAACTAGAGACTTTGATTGGTAGCATCCACGCCCTCCCTGGGCTCATA AGCCAGACCATCAGGCAGCAGCAGAGAGATTTCATTGAGGCTCAGATGGAGAGCTACGAC AAGCACGTCACTTACAATGCTGAGCGGTCCCGGTCCTCGTCCAGGAGGCGGCGGTCCTCT TCCACAGCACCACCAACTTCATCAGAGAGTAGCTAG |
GenBank Gene ID | AF239613 |
GeneCard ID | None |
GenAtlas ID | |
HGNC ID | HGNC:6291 |
Chromosome Location | 5 |
Locus | 5q22.3 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Charybdotoxin |
4324.011 |
||
Scyllatoxin |
3429.202 |