Tyrosine-protein phosphatase non-receptor type 23

NameTyrosine-protein phosphatase non-receptor type 23
Synonyms3.1.3.48 HD-PTP His domain-containing protein tyrosine phosphatase KIAA1471 Protein tyrosine phosphatase TD14 PTP-TD14
Gene NamePTPN23
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009000|Tyrosine-protein phosphatase non-receptor type 23
MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPR
DFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYN
LGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNL
MLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKL
VQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRF
TMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKL
VPMAAHEASSLYSEEKAKLLREMMAKIEDKNEVLDQFMDSMQLDPETVDNLDAYSHIPPQ
LMEKCAALSVRPDTVRNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELLEQKFQEAVGQA
GAISITSKAELAEVRREWAKYMEVHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAAL
PTPALSPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDDITASLVTTDHSEMKK
LFEEQLKKYDQLKVYLEQNLAAQDRVLCALTEANVQYAAVRRVLSDLDQKWNSTLQTLVA
SYEAYEDLMKKSQEGRDFYADLESKVAALLERTQSTCQAREAARQQLLDRELKKKPPPRP
TAPKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSST
GPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMPVAPGPALYPAPAYTPELGLVPRSSPQ
HGVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPRPN
PTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQ
PHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYP
GPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTP
SPHLVPSPAPSPGPGPVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQSPGGGQPL
LQPTKVDAAEGRRPQALRLIERDPYEHPERLRQLQQELEAFRGQLGDVGALDTVWRELQD
AQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLV
ATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLAL
SSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLH
QRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKL
HLRFCYEAVVRHVEQVLQRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQA
TIAKLSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKE
EPPVPEAPSSGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKHNFLQAHNGQGLRATRPS
DDPLSLLDPLWTLNKT
Number of residues1636
Molecular Weight178971.945
Theoretical pINone
GO Classification
Functions
    protein tyrosine phosphatase activity
protein kinase binding
Processes
    peptidyl-tyrosine dephosphorylation
cilium morphogenesis
protein transport
negative regulation of epithelial cell migration
positive regulation of adherens junction organization
positive regulation of early endosome to late endosome transport
positive regulation of homophilic cell adhesion
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Components
    cytoplasmic membrane-bounded vesicle
early endosome
ciliary basal body
cytoplasm
nucleus
extracellular exosome
nucleoplasm
endosome
General FunctionProtein tyrosine phosphatase activity
Specific FunctionPlays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ9H3S7
UniProtKB Entry NamePTN23_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013557|Tyrosine-protein phosphatase non-receptor type 23 (PTPN23)
ATGCTGGGGGCCATGGACAAGCGGGTGTCTGAGGAGGGCATGAAGGTCTCCTGTACCCAT
TTCCAGTGCGCAGCCGGCGCCTTCGCCTACCTACGGGAGCACTTCCCTCAAGCCTACAGC
GTCGACATGAGCCGCCAGATCCTTACGCTCAACGTCAACCTCATGCTGGGCCAGGCTCAG
GAGTGCCTCCTGGAGAAGTCGATGTTGGACAACAGGAAGAGCTTTCTGGTGGCCCGCATC
AGTGCACAGGTGGTAGATTACTACAAGGAGGCATGCCGGGCCTTGGAGAACCCCGACACT
GCCTCACTGCTGGGCCGGATCCAGAAGGACTGGAAGAAACTTGTGCAGATGAAGATCTAC
TACTTCGCAGCCGTGGCTCATCTGCACATGGGAAAGCAGGCCGAGGAGCAGCAGAAGTTC
GGGGAGCGGGTTGCATACTTCCAGAGCGCCCTGGACAAGCTCAATGAAGCCATCAAGTTG
GCCAAGGGCCAGCCTGACACTGTGCAAGACGCGCTTCGCTTCACTATGGATGTCATTGGG
GGAAAGTACAATTCTGCCAAGAAGGACAACGACTTCATTTACCATGAGGCTGTCCCAGCA
TTGGACACTCTTCAGCCTGTAAAAGGAGCCCCCTTGGTGAAGCCCTTGCCAGTGAACCCC
ACAGACCCAGCTGTTACAGGCCCTGACATCTTTGCCAAACTGGTACCCATGGCTGCCCAC
GAGGCCTCGTCACTGTACAGTGAGGAGAAGGCCAAGCTGCTCCGGGAGATGATGGCCAAG
ATTGAGGACAAGAATGAGGTCCTGGACCAGTTCATGGATTCAATGCAGTTGGATCCCGAG
ACGGTGGACAACCTTGATGCCTACAGCCACATCCCACCCCAGCTCATGGAGAAGTGCGCG
GCTCTCAGCGTCCGGCCCGACACTGTCAGGAACCTTGTACAGTCCATGCAAGTGCTGTCA
GGTGTGTTCACGGATGTGGAGGCTTCCCTGAAGGACATCAGAGATCTGTTGGAGGAGGAT
GAGCTGCTAGAGCAGAAGTTTCAGGAGGCGGTGGGCCAGGCAGGGGCCATCTCCATCACC
TCCAAGGCTGAGCTGGCAGAGGTGAGGCGAGAATGGGCCAAGTACATGGAAGTCCATGAG
AAGGCCTCCTTCACCAACAGTGAGCTGCACCGTGCCATGAACCTGCACGTCGGCAACCTG
CGCCTGCTCAGCGGGCCGCTTGACCAGGTCCGGGCTGCCCTGCCCACACCGGCCCTCTCC
CCAGAGGACAAGGCCGTGCTGCAAAACCTAAAGCGCATCCTGGCTAAGGTGCAGGAGATG
CGGGACCAGCGCGTGTCCCTGGAGCAGCAGCTGCGTGAGCTTATCCAGAAAGATGACATC
ACTGCCTCGCTGGTCACCACAGACCACTCAGAGATGAAGAAGTTGTTCGAGGAGCAGCTG
AAAAAGTATGACCAGCTGAAGGTGTACCTGGAGCAGAACCTGGCCGCCCAGGACCGTGTC
CTCTGTGCACTGACAGAGGCCAACGTGCAGTACGCAGCCGTGCGGCGGGTACTCAGCGAC
TTGGACCAAAAGTGGAACTCCACGCTGCAGACCCTGGTGGCCTCGTATGAAGCCTATGAG
GACCTGATGAAGAAGTCGCAGGAGGGCAGGGACTTCTACGCAGATCTGGAGAGCAAGGTG
GCTGCTCTGCTGGAGCGCACGCAGTCCACCTGCCAGGCCCGCGAGGCTGCCCGCCAGCAG
CTCCTGGACAGGGAGCTGAAGAAGAAGCCGCCGCCACGGCCCACAGCCCCAAAGCCGCTG
CTGCCCCGCAGGGAGGAGAGTGAGGCAGTGGAAGCAGGAGACCCCCCTGAGGAGCTGCGC
AGCCTCCCCCCTGACATGGTGGCTGGCCCACGACTGCCTGACACCTTCCTGGGAAGTGCC
ACCCCGCTCCACTTTCCTCCCAGCCCCTTCCCCAGCTCCACAGGCCCAGGACCCCACTAT
CTCTCAGGCCCCTTGCCCCCTGGTACCTACTCGGGCCCCACCCAGCTGATACAGCCCAGG
GCCCCAGGGCCCCATGCAATGCCCGTAGCACCTGGGCCTGCCCTCTACCCAGCCCCTGCC
TACACACCGGAGCTGGGCCTTGTGCCCCGATCCTCCCCACAGCATGGCGTGGTGAGCAGT
CCCTATGTGGGGGTAGGGCCGGCCCCACCAGTTGCAGGTCTCCCCTCGGCCCCACCTCCT
CAATTCTCAGGCCCCGAGTTGGCCATGGCGGTTCGGCCAGCCACCACCACAGTAGATAGC
ATCCAGGCGCCCATCCCCAGCCACACAGCCCCACGGCCAAACCCCACCCCTGCTCCTCCC
CCGCCCTGCTTCCCTGTGCCCCCACCGCAGCCACTGCCCACGCCTTACACCTACCCTGCA
GGGGCTAAGCAACCCATCCCGGCACAGCACCACTTCTCTTCTGGGATCCCCGCAGGTTTT
CCAGCCCCAAGGATTGGGCCCCAGCCCCAGCCCCATCCTCAGCCCCATCCTTCACAAGCG
TTTGGGCCTCAGCCCCCACAGCAGCCCCTTCCACTCCAGCATCCACATCTCTTCCCACCC
CAGGCCCCAGGACTCCTACCCCCACAATCCCCCTACCCCTATGCCCCTCAGCCTGGGGTC
CTGGGGCAGCCGCCACCCCCCCTACACACCCAGCTCTACCCAGGTCCCGCTCAAGACCCT
CTGCCAGCCCACTCAGGGGCTCTGCCTTTCCCCAGCCCTGGGCCCCCTCAGCCTCCCCAT
CCCCCACTGGCATATGGTCCTGCCCCTTCTACCAGACCCATGGGCCCCCAGGCAGCCCCT
CTTACCATTCGAGGGCCCTCGTCTGCTGGCCAGTCCACCCCTAGTCCCCACCTGGTGCCT
TCACCTGCCCCATCTCCAGGGCCTGGTCCGGTACCCCCTCGCCCCCCAGCAGCAGAACCA
CCCCCTTGCCTGCGCCGAGGCGCCGCAGCTGCAGACCTGCTCTCCTCCAGCCCGGAGAGC
CAGCATGGCGGCACTCAGTCTCCTGGGGGTGGGCAGCCCCTGCTGCAGCCCACCAAGGTG
GATGCAGCTGAGGGTCGTCGGCCGCAGGCCCTGCGGCTGATTGAGCGGGACCCCTATGAG
CATCCTGAGAGGCTGCGGCAGTTGCAGCAGGAGCTGGAGGCCTTTCGGGGTCAGCTGGGG
GATGTGGGAGCTCTGGACACTGTCTGGCGAGAGCTGCAAGATGCGCAGGAACATGATGCC
CGAGGCCGTTCCATCGCCATTGCCCGCTGCTACTCACTGAAGAACCGGCACCAGGATGTC
ATGCCCTATGACAGTAACCGTGTGGTGCTGCGCTCAGGCAAGGATGACTACATCAATGCC
AGCTGCGTGGAGGGGCTCTCCCCATACTGCCCCCCGCTAGTGGCAACCCAGGCCCCACTG
CCTGGCACAGCTGCTGACTTCTGGCTCATGGTCCATGAGCAGAAAGTGTCAGTCATTGTC
ATGCTGGTTTCTGAGGCTGAGATGGAGAAGCAAAAAGTGGCACGCTACTTCCCCACCGAG
AGGGGCCAGCCCATGGTGCACGGTGCCCTGAGCCTGGCATTGAGCAGCGTCCGCAGCACC
GAAACCCATGTGGAGCGCGTGCTGAGCCTGCAGTTCCGAGACCAGAGCCTCAAGCGCTCT
CTTGTGCACCTGCACTTCCCCACTTGGCCTGAGTTAGGCCTGCCCGACAGCCCCAGCAAC
TTGCTGCGCTTCATCCAGGAGGTGCACGCACATTACCTGCATCAGCGGCCGCTGCACACG
CCCATCATTGTGCACTGCAGCTCTGGTGTGGGCCGCACGGGAGCCTTTGCACTGCTCTAT
GCAGCTGTGCAGGAGGTGGAGGCTGGGAACGGAATCCCTGAGCTGCCTCAGCTGGTGCGG
CGCATGCGGCAGCAGAGAAAGCACATGCTGCAGGAGAAGCTGCACCTCAGGTTCTGCTAT
GAGGCAGTGGTGAGACACGTGGAGCAGGTCCTGCAGCGCCATGGTGTGCCTCCTCCATGC
AAACCCTTGGCCAGTGCAAGCATCAGCCAGAAGAACCACCTTCCTCAGGACTCCCAGGAC
CTGGTCCTCGGTGGGGATGTGCCCATCAGCTCCATCCAGGCCACCATTGCCAAGCTCAGC
ATTCGGCCTCCTGGGGGGTTGGAGTCCCCGGTTGCCAGCTTGCCAGGCCCTGCAGAGCCC
CCAGGCCTCCCGCCAGCCAGCCTCCCAGAGTCTACCCCAATCCCATCTTCCTCCCCGCCC
CCCCTTTCCTCCCCACTACCTGAGGCTCCCCAGCCTAAGGAGGAGCCGCCAGTGCCTGAA
GCCCCCAGCTCGGGGCCCCCCTCCTCCTCCCTGGAATTGCTGGCCTCCTTGACCCCAGAG
GCCTTCTCCCTGGACAGCTCCCTGCGGGGCAAACAGCGGATGAGCAAGCATAACTTTCTG
CAGGCCCATAACGGGCAAGGGCTGCGGGCCACCCGGCCCTCTGACGACCCCCTCAGCCTT
CTGGATCCACTCTGGACACTCAACAAGACCTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:14406
Chromosome Location3
LocusNone
References
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