G-protein coupled receptor 35


NameG-protein coupled receptor 35
SynonymsKYNA receptor Kynurenic acid receptor
Gene NameGPR35
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009310|G-protein coupled receptor 35
MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMT
NLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRH
PLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGF
YLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVR
LAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKS
QDSLCVTLA
Number of residues309
Molecular Weight34071.89
Theoretical pINone
GO Classification
Functions
    G-protein coupled receptor activity
Processes
    G-protein coupled receptor signaling pathway
Components
    integral component of plasma membrane
General FunctionG-protein coupled receptor activity
Specific FunctionActs as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.
Transmembrane Regions25-45 57-77 91-112 136-156 175-195 219-239 259-279
GenBank Protein ID
UniProtKB IDQ9HC97
UniProtKB Entry NameGPR35_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0019760|G-protein coupled receptor 35 (GPR35)
ATGCTGAGTGGTTCCCGGGCTGTCCCCACTCCACACCGTGGCAGTGAAGAGCTGCTGAAG
TACATGCTTCATAGTCCTTGCGTCTCTCTGACCATGAATGGCACCTACAACACCTGTGGC
TCCAGCGACCTCACCTGGCCCCCAGCGATCAAGCTGGGCTTCTACGCCTACTTGGGCGTC
CTGCTGGTGCTAGGCCTGCTGCTCAACAGCCTGGCGCTCTGGGTGTTCTGCTGCCGCATG
CAGCAGTGGACGGAGACCCGCATCTACATGACCAACCTGGCGGTGGCCGACCTCTGCCTG
CTGTGCACCTTGCCCTTCGTGCTGCACTCCCTGCGAGACACCTCAGACACGCCGCTGTGC
CAGCTCTCCCAGGGCATCTACCTGACCAACAGGTACATGAGCATCAGCCTGGTCACGGCC
ATCGCCGTGGACCGCTATGTGGCCGTGCGGCACCCGCTGCGTGCCCGCGGGCTGCGGTCC
CCCAGGCAGGCTGCGGCCGTGTGCGCGGTCCTCTGGGTGCTGGTCATCGGCTCCCTGGTG
GCTCGCTGGCTCCTGGGGATTCAGGAGGGCGGCTTCTGCTTCAGGAGCACCCGGCACAAT
TTCAACTCCATGGCGTTCCCGCTGCTGGGATTCTACCTGCCCCTGGCCGTGGTGGTCTTC
TGCTCCCTGAAGGTGGTGACTGCCCTGGCCCAGAGGCCACCCACCGACGTGGGGCAGGCA
GAGGCCACCCGCAAGGCTGCCCGCATGGTCTGGGCCAACCTCCTGGTGTTCGTGGTCTGC
TTCCTGCCCCTGCACGTGGGGCTGACAGTGCGCCTCGCAGTGGGCTGGAACGCCTGTGCC
CTCCTGGAGACGATCCGTCGCGCCCTGTACATAACCAGCAAGCTCTCAGATGCCAACTGC
TGCCTGGACGCCATCTGCTACTACTACATGGCCAAGGAGTTCCAGGAGGCGTCTGCACTG
GCCGTGGCTCCCAGTGCTAAGGCCCACAAAAGCCAGGACTCTCTGTGCGTGACCCTCGCC
TAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:4492
Chromosome Location2
LocusNone
References
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