Calcium-activated potassium channel subunit beta-3
Name | Calcium-activated potassium channel subunit beta-3 |
---|---|
Synonyms | BK channel subunit beta-3 BKbeta3 Calcium-activated potassium channel, subfamily M subunit beta-3 Charybdotoxin receptor subunit beta-3 Hbeta3 K(VCA)beta-3 KCNMB2 KCNMBL Maxi K channel subunit beta-3 Slo-beta-3 |
Gene Name | KCNMB3 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0008400|Calcium-activated potassium channel subunit beta-3 MDFSPSSELGFHFVAFILLTRHRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVM LGFAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQ GKYPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDH KNGTPFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLL CEKYSTVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS |
Number of residues | 279 |
Molecular Weight | 31603.26 |
Theoretical pI | 7.31 |
GO Classification |
Functions
potassium channel regulator activity calcium-activated potassium channel activity Processes
neuronal action potential action potential blood coagulation detection of calcium ion potassium ion transport synaptic transmission potassium ion transmembrane transport Components
plasma membrane voltage-gated potassium channel complex integral component of plasma membrane |
General Function | Potassium channel regulator activity |
Specific Function | Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer. |
Transmembrane Regions | 61-81 208-228 |
GenBank Protein ID | 5880671 |
UniProtKB ID | Q9NPA1 |
UniProtKB Entry Name | KCMB3_HUMAN |
Cellular Location | Membrane |
Gene sequence | >lcl|BSEQ0020764|Calcium-activated potassium channel subunit beta-3 (KCNMB3) ATGCAGCCCTTCAGCATCCCCGTGCAAATCACACTTCAGGGCAGCCGGAGGCGCCAGGGG AGGACAGCCTTTCCTGCCTCAGGGAAGAAGAGAGAGACAGACTACAGTGATGGAGACCCA CTAGATGTGCACAAGAGGCTGCCATCCAGTGCTGGAGAGGACCGAGCCGTGATGCTGGGG TTTGCCATGATGGGCTTCTCAGTCCTAATGTTCTTCTTGCTCGGAACAACCATTCTAAAG CCTTTTATGCTCAGCATTCAGAGAGAAGAATCGACCTGCACTGCCATCCACACAGATATC ATGGACGACTGGCTGGACTGTGCCTTCACCTGTGGTGTGCACTGCCACGGTCAGGGGAAG TACCCGTGTCTTCAGGTGTTTGTGAACCTCAGCCATCCAGGTCAGAAAGCTCTCCTACAT TATAATGAAGAGGCTGTCCAGATAAATCCCAAGCGTGATGTTACAGACTGCAGAGTTAAA GAAAAGCAGACATTGACAGTTTCTGATGAGCATAAACAGTAA |
GenBank Gene ID | AF139471 |
GeneCard ID | None |
GenAtlas ID | |
HGNC ID | HGNC:6287 |
Chromosome Location | 3 |
Locus | 3q26.3-q27 |
References |
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