Inward rectifier potassium channel 16

NameInward rectifier potassium channel 16
SynonymsInward rectifier K(+) channel Kir5.1 Potassium channel, inwardly rectifying subfamily J member 16
Gene NameKCNJ16
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017651|Inward rectifier potassium channel 16
MSYYGSSYHIINADAKYPGYPPEHIIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYVVD
IFTTLVDTKWRHMFVIFSLSYILSWLIFGSVFWLIAFHHGDLLNDPDITPCVDNVHSFTG
AFLFSLETQTTIGYGYRCVTEECSVAVLMVILQSILSCIINTFIIGAALAKMATARKRAQ
TIRFSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYTEDSEGRMTMAFKDLKL
VNDQIILVTPVTIVHEIDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYV
PREILWGHRFNDVLEVKRKYYKVNCLQFEGSVEVYAPFCSAKQLDWKDQQLHIEKAPPVR
ESCTSDTKARRRSFSAVAIVSSCENPEETTTSATHEYRETPYQKALLTLNRISVESQM
Number of residues418
Molecular Weight47948.585
Theoretical pINone
GO Classification
Functions
    inward rectifier potassium channel activity
Processes
    potassium ion transport
synaptic transmission
potassium ion import
regulation of ion transmembrane transport
Components
    plasma membrane
voltage-gated potassium channel complex
integral component of plasma membrane
General FunctionInward rectifier potassium channel activity
Specific FunctionInward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance.
Transmembrane Regions71-95 146-167
GenBank Protein ID
UniProtKB IDQ9NPI9
UniProtKB Entry NameKCJ16_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0017652|Inward rectifier potassium channel 16 (KCNJ16)
ATGAGCTATTACGGCAGCAGCTATCATATTATCAATGCGGACGCAAAATACCCAGGCTAC
CCGCCAGAGCACATTATAGCTGAGAAGAGAAGAGCAAGAAGACGATTACTTCACAAAGAT
GGCAGCTGTAATGTCTACTTCAAGCACATTTTTGGAGAATGGGGAAGCTATGTGGTTGAC
ATCTTCACCACTCTTGTGGACACCAAGTGGCGCCATATGTTTGTGATATTTTCTTTATCT
TATATTCTCTCGTGGTTGATATTTGGCTCTGTCTTTTGGCTCATAGCCTTTCATCATGGC
GATCTATTAAATGATCCAGACATCACACCTTGTGTTGACAACGTCCATTCTTTCACAGGG
GCCTTTTTGTTCTCCCTAGAGACCCAAACCACCATAGGATATGGTTATCGCTGTGTTACT
GAAGAATGTTCTGTGGCCGTGCTCATGGTGATCCTCCAGTCCATCTTAAGTTGCATCATA
AATACCTTTATCATTGGAGCTGCCTTGGCCAAAATGGCAACTGCTCGAAAGAGAGCCCAA
ACCATTCGTTTCAGCTACTTTGCACTTATAGGTATGAGAGATGGGAAGCTTTGCCTCATG
TGGCGCATTGGTGATTTTCGGCCAAACCACGTGGTAGAAGGAACAGTTAGAGCCCAACTT
CTCCGCTATACAGAAGACAGTGAAGGGAGGATGACGATGGCATTTAAAGACCTCAAATTA
GTCAACGACCAAATCATCCTGGTCACCCCGGTAACTATTGTCCATGAAATTGACCATGAG
AGCCCTCTGTATGCCCTTGACCGCAAAGCAGTAGCCAAAGATAACTTTGAGATTTTGGTG
ACATTTATCTATACTGGTGATTCCACTGGAACATCTCACCAATCTAGAAGCTCCTATGTT
CCCCGAGAAATTCTCTGGGGCCATAGGTTTAATGATGTCTTGGAAGTTAAGAGGAAGTAT
TACAAAGTGAACTGCTTACAGTTTGAAGGAAGTGTGGAAGTATATGCCCCCTTTTGCAGT
GCCAAGCAATTGGACTGGAAAGACCAGCAGCTCCACATAGAAAAAGCACCACCAGTTCGA
GAATCCTGCACGTCGGACACCAAGGCGAGACGAAGGTCATTTAGTGCAGTTGCCATTGTC
AGCAGCTGTGAAAACCCTGAGGAGACCACCACTTCCGCCACACATGAATATAGGGAAACA
CCTTATCAGAAAGCTCTCCTGACTTTAAACAGAATCTCTGTAGAATCCCAAATGTAG
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:6262
Chromosome Location17
LocusNone
References
  1. Liu Y, McKenna E, Figueroa DJ, Blevins R, Austin CP, Bennett PB, Swanson R: The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas. Cytogenet Cell Genet. 2000;90(1-2):60-3.[11060447 ]
  2. Derst C, Karschin C, Wischmeyer E, Hirsch JR, Preisig-Muller R, Rajan S, Engel H, Grzeschik K, Daut J, Karschin A: Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits. FEBS Lett. 2001 Mar 2;491(3):305-11.[11240146 ]

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FRCD ID Name Exact Mass Structure




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