Sodium channel subunit beta-3
Name | Sodium channel subunit beta-3 |
---|---|
Synonyms | KIAA1158 |
Gene Name | SCN3B |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0006991|Sodium channel subunit beta-3 MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVV EWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTC NVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLLIEMIYC YRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE |
Number of residues | 215 |
Molecular Weight | 24702.08 |
Theoretical pI | 4.35 |
GO Classification |
Functions
ion channel binding voltage-gated sodium channel activity voltage-gated sodium channel activity involved in cardiac muscle cell action potential sodium channel regulator activity Processes
sensory perception of pain regulation of atrial cardiac muscle cell membrane depolarization positive regulation of heart rate regulation of heart rate by cardiac conduction regulation of ventricular cardiac muscle cell membrane depolarization sodium ion transport SA node cell action potential ventricular cardiac muscle cell action potential cardiac muscle cell action potential involved in contraction cardiac muscle contraction regulation of sodium ion transmembrane transporter activity membrane depolarization atrial cardiac muscle cell action potential sodium ion transmembrane transport membrane depolarization during action potential nervous system development membrane depolarization during cardiac muscle cell action potential protein localization to plasma membrane positive regulation of sodium ion transport Components
Z disc voltage-gated sodium channel complex plasma membrane integral component of membrane |
General Function | Voltage-gated sodium channel activity involved in cardiac muscle cell action potential |
Specific Function | Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). |
Transmembrane Regions | 160-180 |
GenBank Protein ID | 7160975 |
UniProtKB ID | Q9NY72 |
UniProtKB Entry Name | SCN3B_HUMAN |
Cellular Location | Membrane |
Gene sequence | >lcl|BSEQ0012530|Sodium channel subunit beta-3 (SCN3B) ATGCCTGCCTTCAATAGATTGTTTCCCCTGGCTTCTCTCGTGCTTATCTACTGGGTCAGT GTCTGCTTCCCTGTGTGTGTGGAAGTGCCCTCGGAGACGGAGGCCGTGCAGGGCAACCCC ATGAAGCTGCGCTGCATCTCCTGCATGAAGAGAGAGGAGGTGGAGGCCACCACGGTGGTG GAATGGTTCTACAGGCCCGAGGGCGGTAAAGATTTCCTTATTTACGAGTATCGGAATGGC CACCAGGAGGTGGAGAGCCCCTTTCAGGGGCGCCTGCAGTGGAATGGCAGCAAGGACCTG CAGGACGTGTCCATCACTGTGCTCAACGTCACTCTGAACGACTCTGGCCTCTACACCTGC AATGTGTCCCGGGAGTTTGAGTTTGAGGCGCATCGGCCCTTTGTGAAGACGACGCGGCTG ATCCCCCTAAGAGTCACCGAGGAGGCTGGAGAGGACTTCACCTCTGTGGTCTCAGAAATC ATGATGTACATCCTTCTGGTCTTCCTCACCTTGTGGCTGCTCATCGAGATGATATATTGC TACAGAAAGGTCTCAAAAGCCGAAGAGGCAGCCCAAGAAAACGCGTCTGACTACCTTGCC ATCCCATCTGAGAACAAGGAGAACTCTGCGGTACCAGTGGAGGAATAG |
GenBank Gene ID | AJ243396 |
GeneCard ID | None |
GenAtlas ID | |
HGNC ID | HGNC:20665 |
Chromosome Location | 11 |
Locus | 11q23.3 |
References |
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