Retinol dehydrogenase 8


NameRetinol dehydrogenase 8
Synonyms1.1.1.300 Photoreceptor outer segment all-trans retinol dehydrogenase PRRDH SDR28C2 Short chain dehydrogenase/reductase family 28C member 2
Gene NameRDH8
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004562|Retinol dehydrogenase 8
MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTL
TVAQLDVCSDESVAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVR
LVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFI
SLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQ
AIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQCLS
CGCLPTRVRPR
Number of residues311
Molecular Weight33755.02
Theoretical pI8.48
GO Classification
Functions
    retinol dehydrogenase activity
    NADP-retinol dehydrogenase activity
    estradiol 17-beta-dehydrogenase activity
Processes
    retinoid metabolic process
    visual perception
    steroid biosynthetic process
    phototransduction, visible light
    estrogen biosynthetic process
Components
    cytoplasm
    integral component of plasma membrane
General FunctionRetinol dehydrogenase activity
Specific FunctionRetinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity).
Transmembrane Regions86-106 137-157 169-189
GenBank Protein ID7527474
UniProtKB IDQ9NYR8
UniProtKB Entry NameRDH8_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0019270|Retinol dehydrogenase 8 (RDH8)
ATGAATGGTCAGAGTCAGGTGCTGCCCGGCGGAGGTCACGAGTCCAGGGAGGGGATCAAC
ATGGCCGCTGCACCCCGGACTGTGTTGATCTCCGGCTGCTCATCAGGAATTGGTCTGGAA
CTTGCAGTGCAACTGGCCCATGACCCCAAGAAGCGCTACCAGGTCGTGGCCACCATGAGG
GACCTGGGGAAGAAGGAGACACTGGAGGCAGCTGCTGGGGAGGCTCTGGGGCAGACCCTC
ACCGTGGCCCAGCTGGACGTGTGCAGTGATGAGTCGGTGGCCCAGTGTCTCAGCTGTATC
CAGGGAGAAGTGGACGTGCTGGTGAATAATGCTGGAATGGGCCTGGTGGGGCCCCTGGAG
GGGCTCAGCCTTGCTGCCATGCAGAATGTCTTTGACACCAACTTTTTCGGAGCTGTCCGT
CTCGTCAAAGCTGTGCTTCCAGGCATGAAGAGGAGGCGGCAGGGCCACATCGTGGTGATC
AGCAGTGTCATGGGCCTGCAGGGTGTCATCTTCAACGATGTCTATGCAGCTTCCAAGTTC
GCCCTGGAGGGATTCTTCGAAAGCCTCGCTATCCAGCTGCTGCAGTTCAACATCTTCATC
TCCCTGGTGGAGCCAGGCCCCGTGGTCACCGAGTTTGAGGGGAAGCTTCTGGCGCAGGTT
TCTATGGCTGAGTTCCCAGGCACTGACCCTGAGACCCTGCACTACTTCCGGGACCTCTAT
CTCCCAGCCTCCAGGAAGCTGTTTTGCTCCGTGGGACAGAACCCACAGGACGTGGTTCAG
GCCATTGTCAACGTCATCAGCTCGACTCGACCACCCCTGCGCCGACAGACCAACATCCGC
TACTCGCCGCTGACCACGCTCAAAACCGTGGATTCCTCTGGCAGCCTGTATGTGCGAACG
ACCCACCGCCTCCTCTTCCGCTGTCCACGCCTCCTCAACCTTGGCCTTCAATGTCTGTCC
TGCGGCTGCCTCCCAACGCGGGTGCGGCCAAGATGA
GenBank Gene IDAF229845
GeneCard IDNone
GenAtlas IDRDH8
HGNC IDHGNC:14423
Chromosome Location19
Locus19p13.2-p13.3
References
  1. Rattner A, Smallwood PM, Nathans J: Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol. J Biol Chem. 2000 Apr 14;275(15):11034-43.[10753906 ]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21.[14702039 ]

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