SEC14-like protein 3

NameSEC14-like protein 3
SynonymsTAP2 Tocopherol-associated protein 2
Gene NameSEC14L3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000675|SEC14-like protein 3
MSGRVGDLSPKQAETLAKFRENVQDVLPALPNPDDYFLLRWLRARNFDLQKSEALLRKYM
EFRKTMDIDHILDWQPPEVIQKYMPGGLCGYDRDGCPVWYDIIGPLDPKGLLFSVTKQDL
LKTKMRDCERILHECDLQTERLGKKIETIVMIFDCEGLGLKHFWKPLVEVYQEFFGLLEE
NYPETLKFMLIVKATKLFPVGYNLMKPFLSEDTRRKIIVLGNNWKEGLLKLISPEELPAQ
FGGTLTDPDGNPKCLTKINYGGEIPKSMYVRDQVKTQYEHSVQINRGSSHQVEYEILFPG
CVLRWQFSSDGADIGFGVFLKTKMGERQRAGEMTDVLPSQRYNAHMVPEDGNLTCSEAGV
YVLRFDNTYSFVHAKKVSFTVEVLLPDEGMQKYDKELTPV
Number of residues400
Molecular Weight46047.835
Theoretical pI5.97
GO Classification
Functions
    transporter activity
lipid binding
Processes

                

              
Components

                

                  
    intracellular
integral component of membrane
extracellular exosome

                

              

          		
      

      
General FunctionTransporter activity

      
Specific FunctionProbable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

      
Transmembrane Regions

      
GenBank Protein ID27803382  

      
UniProtKB IDQ9UDX4  

      
UniProtKB Entry NameS14L3_HUMAN  

      
Cellular LocationNone

      
Gene sequence
>lcl|BSEQ0010254|SEC14-like protein 3 (SEC14L3)
ATGGTGATCCAGAAGTACATGCCTGGGGGCCTGTGTGGCTATGACCGTGATGGCTGCCCC
GTGTGGTATGACATCATTGGGCCACTTGATCCCAAGGGGTTGCTCTTCTCAGTCACCAAG
CAGGACCTGCTCAAGACCAAGATGAGGGACTGTGAGCGCATCCTGCATGAGTGTGACCTG
CAGACAGAGAGGCTAGGGAAGAAGATTGAGACCATCGTGATGATATTTGACTGTGAGGGC
CTGGGACTGAAACACTTCTGGAAACCTCTGGTAGAAGTGTACCAGGAGTTCTTTGGCCTC
CTTGAAGAGAATTACCCAGAGACCCTGAAGTTCATGCTCATCGTGAAAGCTACCAAACTG
TTCCCTGTGGGCTACAACCTCATGAAGCCATTCCTGAGTGAGGACACTCGCAGGAAAATT
ATTGTGTTGGGAAATAACTGGAAGGAAGGTTTGCTGAAACTCATCAGTCCTGAGGAACTG
CCTGCCCAGTTTGGGGGCACCCTGACTGACCCAGATGGGAACCCCAAATGTTTAACCAAG
ATTAACTATGGCGGGGAGATCCCCAAGTCCATGTACGTGCGGGACCAGGTGAAGACTCAG
TACGAGCACTCGGTGCAGATCAACCGCGGCTCATCACACCAAGTGGAATACGAGATCCTA
TTTCCAGGCTGCGTTCTCAGGTGGCAGTTCTCATCTGATGGTGCGGACATCGGCTTCGGA
GTTTTCCTGAAGACCAAGATGGGGGAGCGACAGCGGGCAGGGGAGATGACAGATGTTCTA
CCCAGCCAGCGCTATAACGCCCACATGGTGCCCGAGGATGGGAACCTCACCTGCTCAGAG
GCCGGCGTCTATGTCCTACGCTTCGACAACACCTATAGCTTTGTCCACGCCAAGAAGGTC
AGCTTCACAGTGGAGGTCCTGCTCCCTGACGAGGGCATGCAGAAATATGATAAGGAGCTC
ACCCCTGTCTAG

      
GenBank Gene IDAY158086  

      
GeneCard IDNone

      
GenAtlas IDSEC14L3  

      
HGNC IDHGNC:18655  

      
Chromosome Location22

      
Locus22q12.2

      
References
        
          
    
            
            
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334  ]
    2. 
            
            
  2. Kempna P, Zingg JM, Ricciarelli R, Hierl M, Saxena S, Azzi A: Cloning of novel human SEC14p-like proteins: ligand binding and functional properties. Free Radic Biol Med. 2003 Jun 1;34(11):1458-72.[12757856  ]
    3. 
            
            
  3. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.: The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95.[10591208  ]
    4. 
            
          

        		
      

    

    


      
    
Related FRC

      

    

    
        

            FRCD ID
            Name
            Exact Mass
            
            Structure
        

        
        

        
        

            
                

                



F04736
                

            		
            


Alpha-Tocopherol

            


430.717