Peroxisomal carnitine O-octanoyltransferase
| Name | Peroxisomal carnitine O-octanoyltransferase |
|---|---|
| Synonyms | 2.3.1.137 COT |
| Gene Name | CROT |
| Organism | Human |
| Amino acid sequence | >lcl|BSEQ0000743|Peroxisomal carnitine O-octanoyltransferase MENQLAKSTEERTFQYQDSLPSLPVPSLEESLKKYLESVKPFANQEEYKKTEEIVQKFQS GIGEKLHQKLLERAKGKRNWLEEWWLNVAYLDVRIPSQLNVNFAGPAAHFEHYWPPKEGT QLERGSITLWHNLNYWQLLRKEKVPVHKVGNTPLDMNQFRMLFSTCKVPGITRDSIMNYF RTESEGRSPNHIVVLCRGRAFVFDVIHEGCLVTPPELLRQLTYIHKKCHSEPDGPGIAAL TSEERTRWAKAREYLIGLDPENLALLEKIQSSLLVYSMEDSSPHVTPEDYSEIIAAILIG DPTVRWGDKSYNLISFSNGVFGCNCDHAPFDAMIMVNISYYVDEKIFQNEGRWKGSEKVR DIPLPEELIFIVDEKVLNDINQAKAQYLREASDLQIAAYAFTSFGKKLTKNKMLHPDTFI QLALQLAYYRLHGHPGCCYETAMTRHFYHGRTETMRSCTVEAVRWCQSMQDPSVNLRERQ QKMLQAFAKHNKMMKDCSAGKGFDRHLLGLLLIAKEEGLPVPELFTDPLFSKSGGGGNFV LSTSLVGYLRVQGVVVPMVHNGYGFFYHIRDDRFVVACSAWKSCPETDAEKLVQLTFCAF HDMIQLMNSTHL |
| Number of residues | 612 |
| Molecular Weight | 70177.935 |
| Theoretical pI | 7.09 |
| GO Classification |
Functions
receptor binding carnitine O-octanoyltransferase activity Processes
carnitine metabolic process cellular lipid metabolic process generation of precursor metabolites and energy fatty acid metabolic process fatty acid transport fatty acid beta-oxidation using acyl-CoA oxidase fatty acid beta-oxidation medium-chain fatty acid metabolic process small molecule metabolic process coenzyme A metabolic process Components
peroxisomal matrix mitochondrion peroxisome intracellular membrane-bounded organelle |
| General Function | Receptor binding |
| Specific Function | Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester. |
| Transmembrane Regions | |
| GenBank Protein ID | 6066280 |
| UniProtKB ID | Q9UKG9 |
| UniProtKB Entry Name | OCTC_HUMAN |
| Cellular Location | Peroxisome |
| Gene sequence | >lcl|BSEQ0016074|Peroxisomal carnitine O-octanoyltransferase (CROT) ATGGAAAATCAATTGGCTAAATCAACTGAAGAACGAACATTTCAGTACCAGGATTCTCTT CCATCACTGCCTGTTCCTTCACTTGAAGAATCATTAAAAAAATACCTTGAATCAGTCACC AGAACATGCTACCAGATAAGGGGTCTTGATCCAGATGCTAAGAGAGGGTTCTTGGATCTC ACGCGGGAAGGAATTCAAGTGAAACCATTTGCAAATCAAGAAGAATATAAGAAAACTGAA GAAATAGTTCAAAAATTTCAAAGTGGGATTGGAGAAAAATTGCACCAGAAATTGCTTGAA AGAGCAAAAGGAAAAAGAAATTGGCTGGAAGAGTGGTGGCTGAATGTTGCCTATCTGGAT GTTCGTATACCATCACAATTGAATGTCAACTTTGCGGGTCCTGCAGCTCATTTTGAACAC TACTGGCCTCCAAAGGAAGGGACTCAATTAGAAAGAGGAAGTATAACTCTTTGGCATAAC TTGAACTACTGGCAGCTATTAAGAAAAGAAAAAGTGCCTGTTCATAAAGTTGGAAATACT CCTCTAGATATGAATCAATTCCGAATGCTATTTTCTACCTGCAAGGTTCCAGGAATTACT AGAGACTCCATTATGAATTATTTTAGGACTGAGAGTGAAGGGCGTTCCCCAAACCACATT GTAGTGCTGTGTCGAGGCCGAGCTTTTGTCTTTGATGTAATACATGAAGGATGTTTGGTC ACCCCGCCAGAGCTTCTCAGACAACTGACATATATCCACAAGAAGTGCCATAGTGAACCT GATGGACCTGGGATTGCAGCATTAACTAGTGAGGAGCGAACTCGATGGGCTAAGGCACGA GAATATCTGATTGGTCTTGATCCAGAGAACTTGGCTTTGTTAGAAAAAATTCAGAGTAGT TTACTGGTATATTCCATGGAGGATAGCAGTCCACATGTAACACCAGAGGATTATTCTGAG ATTATTGCAGCCATCCTTATTGGAGATCCAACAGTACGCTGGGGTGACAAATCCTATAAC TTGATTTCCTTTTCTAATGGAGTATTTGGCTGTAATTGTGATCATGCTCCTTTTGATGCA ATGATTATGGTGAACATCAGTTATTATGTGGATGAGAAAATTTTTCAGAATGAAGGAAGA TGGAAGGGTTCAGAGAAGGTACGAGATATACCACTTCCAGAAGAGCTCATTTTCATTGTG GATGAGAAAGTTTTAAATGACATCAACCAAGCTAAAGCCCAGTATCTCAGGGAGGCATCT GATCTACAGATTGCGGCTTATGCCTTTACATCTTTTGGCAAAAAGCTAACCAAGAACAAG ATGCTTCACCCGGATACGTTTATTCAGCTTGCACTTCAGCTGGCCTATTACAGACTTCAT GGACACCCTGGTTGTTGCTATGAAACAGCTATGACAAGACATTTTTATCATGGCCGTACA GAGACTATGCGATCATGCACAGTTGAAGCAGTGAGGTGGTGCCAGTCCATGCAGGATCCT TCTGTCAATCTTCGTGAGCGGCAGCAAAAGATGTTACAAGCTTTTGCAAAGCATAATAAA ATGATGAAAGATTGTTCAGCTGGAAAAGGATTTGATCGTCACCTTTTAGGTCTCTTACTC ATAGCAAAAGAGGAAGGTCTTCCTGTTCCAGAACTCTTTACGGACCCACTTTTTTCCAAA AGCGGAGGAGGTGGAAATTTTGTTCTCTCAACAAGTCTGGTTGGCTATTTACGAGTCCAG GGAGTGGTAGTTCCCATGGTACACAATGGTTATGGATTTTTCTACCATATCAGAGATGAC AGGTTTGTTGTGGCCTGTTCAGCCTGGAAATCCTGTCCCGAGACTGATGCGGAAAAGCTA GTTCAGCTGACTTTTTGTGCTTTTCATGATATGATACAGCTGATGAACTCTACTCATCTT TAG |
| GenBank Gene ID | AF168793 |
| GeneCard ID | None |
| GenAtlas ID | CROT |
| HGNC ID | HGNC:2366 |
| Chromosome Location | 7 |
| Locus | 7q21.1 |
| References |
|
Related FRC
| FRCD ID | Name | Exact Mass | Structure |
|---|---|---|---|
L-Carnitine |
161.201 |