FRCD

Kinesin-like protein KIF26A

Name	Kinesin-like protein KIF26A
Synonyms	KIAA1236
Gene Name	KIF26A
Organism	Human
Amino acid sequence	>lcl\|BSEQ0009144\|Kinesin-like protein KIF26A MVGRGVPLCAAQPAVAEGGPAREPPPLLEVSPRKRLPAGPDQDPCGSRPAPEGAGAGPEQ GHSAGGGGWCRHCHTKLVELKRQAWKLVSGPGTTLRDPCLSALLLDKLPAPGALPACRPE AERRCDVCATHLQQLTREAMHLLQAPASHEDLDAPHGGPSLAPPSTTTSSRDTPGPAGPA GRQPGRAGPDRTKGLAWSPGPSVQVSVAPAGLGGALSTVTIQAQQCLEGMWSVSRVNSFL PPACLAEAAVAAVAVADTVRECPPVAGPDGLSKAWGRGGVCTSALVTPTPGSVGGSTGPS AAASFFIRAMQKLSLASKRKKPHPPPPPATRGTSTYPTDFSGVLQLWPPPAPPCLLRAAS KTKDNPGSIGKVKVMLRIWPAQGAQRSAEAMSFLKVDPRKKQVILYDPAAGPPGSAGPRR AATAAVPKMFAFDAVFPQDSEQAEVCSGTVADVLQSVVSGADGCIFSFGHMSLGKSYTMI GKDSSPQSLGIVPCAISWLFRLIEERRERTGTRFSVRVSAVEVCGRDQSLRDLLAEVAPG SLQDTQSPGVYLREDPVCGAQLQNQSELRAPTAEKAAFYLDAALAARSTSRAGCGEDARR SSHMLFTLHVYQYRMEKCGRGGMSGGRSRLHLIDLGSCEAAAGRAGEAAGGPLCLSLSAL GSVILALVNGAKHVPYRDHRLTMLLRESLATAGCRTTMIAHVSDAPAQHAETLSTVQLAA RIHRLRRKKAKYASSSSGGESSCEEGRARRPPHLRPFHPRTVALDPDRTPPCLPGDPDYS SSSEQSCDTVIYVGPGGAALSDRELTDNEGPPDFVPIIPALSRHRPSKGPRDADHFRCST FAELQERLECMDGNEGPSGGPGGTDGAQASPARGGRKPSPPEAASPRKAVGTPMAASTPR GSSGPDTHQGTPEPCKAIVWGDQREDSSAWPELLVPEKAAVSGGRRPLPSPAPPPPQLLE ACRAPEEPGGGGTDGVARTPPVGMSGQVAGSPMLPGATCPRLAAGSRCPERGLLTTTVTL QRPVELNGEDELVFTVVEELSLGALAGAGRPTSLASFDSDCSLRALASGSRPVSIISSIN DEFDAYTSQAPEGGPLEGAAWAGSSHGSSISSWLSEVSVCTADSRDPTPQPRFSPDSLAG LDPGGPPALDGSLGDGSSGFLGPDRPDSPGPTWGPCPGEVAAVAPSRPGREPQAGPSRWA SAAQTIHSSLPRKPRTASATTRVGCARLGQSPPGRGGLFEDPWLLRVGECDTQAASAGRA PSPTLGSPRLPEAQVMLACAQRVVDGCEVAARAARRPEAVARIPPLRRGATTLGVTTPAV SWGDAPTEVVACSGSLKASPTSKKGLAPKAGFLPRPSGAAPPAPPTRKSSLEQRSSPASA PPHAVNPARVGAAAVLRGEEEPRPSSRADHSVPRATSSLKARASKVEAAHRLAGHASLER YEGLAHSSSKGREAPGRPPRAVPKLGVPPSSPTHGPAPACRSGAAKAVGAPKPPVGGGKG RGLVAGGSRALGPSVKLSTASVTGRSPGGPVAGPRAAPRAGPSVGAKAGRGTVMGTKQAL RAAHSRVHELSASGAPGRGGSSWGSADSDSGHDSGVNVGEERPPTGPALPSPYSKVTAPR RPQRYSSGHGSDNSSVLSGELPPAMGRTALFHHSGGSSGYESLRRDSEATGSASSAPDSM SESGAASPGARTRSLKSPKKRATGLQRRRLIPAPLPDTTALGRKPSLPGQWVDLPPPLAG SLKEPFEIKVYEIDDVERLQRPRPTPREAPTQGLACVSTRLRLAERRQQRLREVQAKHKH LCEELAETQGRLMLEPGRWLEQFEVDPELEPESAEYLAALERATAALEQCVNLCKAHVMM VTCFDISVAASAAIPGPQEVDV
Number of residues	1882
Molecular Weight	194587.415
Theoretical pI	None
GO Classification	Functions microtubule binding ATP binding microtubule motor activity Processes antigen processing and presentation of exogenous peptide antigen via MHC class II negative regulation of signal transduction enteric nervous system development regulation of cell growth by extracellular stimulus microtubule-based movement blood coagulation Components cytosol kinesin complex microtubule
General Function	Microtubule motor activity
Specific Function	Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity).
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	Q9ULI4
UniProtKB Entry Name	KI26A_HUMAN
Cellular Location	Cytoplasm
Gene sequence	>lcl\|BSEQ0013638\|Kinesin-like protein KIF26A (KIF26A) ATGGTCGGCCGCGGCGTCCCTCTGTGCGCTGCGCAGCCCGCGGTGGCCGAGGGCGGCCCG GCCCGCGAGCCGCCGCCGCTGCTGGAGGTGTCCCCCCGAAAGAGGCTACCCGCCGGGCCC GACCAGGACCCATGCGGCAGCCGCCCTGCTCCCGAAGGCGCCGGGGCCGGCCCAGAGCAG GGCCACTCGGCCGGCGGAGGCGGCTGGTGCCGCCACTGCCACACGAAGCTGGTGGAGCTC AAGCGACAGGCGTGGAAGCTGGTCAGCGGGCCCGGGACCACCCTCCGGGATCCTTGCCTC TCTGCCCTGCTTCTCGACAAGCTACCAGCACCTGGGGCCCTGCCAGCCTGTCGCCCAGAG GCCGAGCGCCGCTGTGACGTCTGCGCCACACACCTGCAGCAGCTCACACGGGAGGCCATG CACCTGCTGCAGGCCCCTGCCAGCCATGAGGACCTTGACGCCCCCCATGGAGGCCCCAGC CTCGCACCCCCCAGCACCACGACCAGCTCGAGGGACACGCCAGGACCAGCGGGTCCTGCA GGGAGGCAGCCAGGACGAGCTGGGCCAGACAGGACCAAGGGGCTGGCCTGGTCCCCCGGG CCCAGTGTCCAGGTGTCTGTAGCACCTGCGGGTCTTGGAGGGGCGCTGAGCACGGTCACC ATCCAGGCCCAGCAGTGCCTGGAGGGCATGTGGAGTGTCTCGCGGGTCAACAGCTTCCTC CCGCCGGCGTGCCTGGCCGAGGCAGCGGTGGCGGCCGTGGCGGTGGCAGACACGGTCCGA GAATGCCCCCCCGTGGCCGGCCCTGATGGCTTGTCGAAGGCCTGGGGCCGTGGTGGAGTC TGCACGTCAGCCCTGGTCACCCCCACCCCGGGCTCGGTGGGGGGCTCCACAGGCCCCTCA GCTGCAGCCTCCTTCTTCATAAGGGCTATGCAGAAGCTCAGCCTGGCCTCCAAGAGGAAG AAGCCCCACCCGCCACCGCCTCCAGCCACCCGCGGCACCTCCACCTACCCCACCGACTTC AGCGGGGTCCTGCAGCTGTGGCCGCCCCCGGCGCCCCCCTGCCTGCTCAGGGCCGCCTCC AAGACCAAGGACAACCCTGGCAGCATCGGGAAGGTGAAGGTTATGCTGCGGATCTGGCCC GCACAGGGGGCCCAGCGCTCGGCCGAGGCCATGTCCTTCCTGAAGGTGGACCCTCGGAAG AAGCAGGTGATCCTCTACGATCCCGCCGCCGGTCCCCCAGGCAGCGCAGGCCCCCGGCGA GCCGCCACTGCTGCAGTTCCCAAGATGTTTGCCTTCGATGCCGTCTTCCCCCAGGACTCC GAGCAGGCCGAAGTCTGCTCGGGGACCGTGGCCGACGTGCTCCAGTCGGTGGTCAGTGGG GCTGATGGCTGCATTTTTTCCTTTGGCCACATGAGCCTGGGCAAGTCGTACACCATGATC GGGAAGGACAGCTCACCCCAGAGCCTGGGCATCGTGCCCTGCGCCATCTCCTGGCTCTTC AGGCTCATCGAGGAGCGCAGGGAGAGGACGGGCACCCGCTTCTCCGTCCGGGTCTCAGCC GTGGAGGTGTGCGGGCGCGACCAGAGCCTGCGGGACCTGCTGGCCGAGGTGGCCCCTGGC AGCCTCCAGGACACCCAGTCTCCGGGAGTGTACCTGCGGGAGGACCCCGTGTGTGGGGCG CAGCTCCAGAACCAAAGCGAGCTGCGGGCACCCACGGCCGAGAAGGCGGCTTTCTACCTG GATGCGGCCCTGGCGGCCCGCAGCACCAGCCGAGCGGGCTGTGGCGAGGACGCCCGACGC AGCTCCCACATGTTGTTCACGCTGCACGTCTACCAGTACCGCATGGAGAAGTGCGGCCGG GGAGGAATGTCCGGAGGCCGCAGCCGCCTGCACCTCATCGACCTGGGCAGCTGTGAGGCG GCGGCTGGCAGGGCCGGGGAGGCTGCTGGGGGTCCCCTGTGTCTGTCCCTGTCGGCCCTG GGCAGCGTCATCTTGGCCCTGGTCAACGGAGCCAAGCATGTGCCGTATCGGGACCACAGG CTCACCATGCTGCTGCGTGAATCCCTGGCCACCGCTGGCTGCCGCACCACCATGATCGCC CACGTGTCGGATGCGCCAGCCCAGCACGCAGAGACACTCAGCACCGTGCAGCTCGCCGCC CGCATCCACCGCCTGCGCAGGAAGAAGGCCAAGTACGCCTCCAGCTCCTCTGGCGGGGAG AGCTCCTGTGAGGAAGGCCGGGCCCGTCGGCCCCCGCACCTGCGGCCCTTCCACCCACGC ACTGTGGCCCTGGACCCCGACCGCACGCCTCCCTGCCTGCCCGGTGACCCCGATTACTCC TCCAGCAGCGAGCAGTCCTGTGACACGGTCATCTACGTGGGGCCCGGTGGGGCGGCGCTG TCAGACCGGGAGCTCACCGACAACGAAGGTCCGCCTGACTTCGTGCCCATCATCCCTGCC CTGAGCCGCCACCGGCCCTCCAAGGGTCCCCGAGACGCAGACCACTTCCGCTGCAGCACC TTCGCGGAGCTGCAGGAGCGGCTGGAATGCATGGACGGCAACGAGGGTCCCTCAGGAGGT CCAGGTGGCACCGACGGAGCTCAGGCCAGCCCCGCCCGAGGGGGCCGGAAGCCCTCGCCA CCAGAGGCTGCATCCCCCAGGAAGGCCGTGGGCACCCCGATGGCTGCCAGCACCCCTCGA GGCAGTTCTGGTCCAGACACCCACCAGGGTACCCCTGAGCCCTGCAAGGCCATTGTCTGG GGTGACCAGAGAGAGGACAGCAGCGCTTGGCCTGAGCTGCTGGTCCCGGAAAAGGCTGCA GTGAGTGGAGGCAGGAGGCCACTGCCCAGCCCGGCTCCCCCACCTCCTCAGTTGCTGGAA GCCTGCAGAGCCCCAGAAGAGCCTGGGGGAGGGGGCACTGATGGAGTGGCACGGACCCCT CCCGTGGGCATGAGTGGGCAGGTGGCTGGGTCCCCGATGCTTCCTGGGGCCACCTGCCCC CGCCTGGCTGCTGGCAGTCGCTGTCCGGAGCGGGGCCTGCTCACCACCACAGTGACCCTG CAGCGGCCAGTGGAGCTCAACGGCGAGGACGAGCTGGTGTTCACGGTGGTGGAGGAGCTG TCCCTGGGGGCGCTTGCCGGAGCTGGGCGGCCCACCAGCCTGGCTAGCTTCGACAGTGAC TGCTCCCTGCGGGCCCTGGCCTCGGGGTCCCGGCCAGTCAGCATCATCAGCAGCATCAAT GATGAGTTTGACGCCTACACCTCTCAGGCCCCTGAGGGGGGGCCCCTGGAGGGGGCAGCC TGGGCCGGCAGCAGTCACGGCTCCTCCATCAGCTCCTGGCTCAGCGAGGTCAGCGTCTGC ACTGCCGACAGCCGTGACCCCACGCCGCAGCCCCGCTTCAGCCCCGACTCGCTGGCAGGG CTTGACCCTGGGGGCCCCCCTGCCCTGGATGGTTCCCTGGGGGATGGAAGCTCTGGGTTC CTGGGGCCAGACAGACCTGACAGTCCTGGGCCAACCTGGGGTCCGTGCCCTGGGGAAGTG GCTGCAGTGGCCCCATCCCGACCCGGCAGGGAGCCCCAGGCCGGGCCCTCGCGGTGGGCA TCCGCAGCCCAGACCATCCACTCCAGCCTCCCCCGGAAACCGAGGACTGCCTCTGCCACC ACCCGTGTGGGCTGTGCTCGCCTGGGCCAGAGCCCACCTGGCCGTGGAGGCCTGTTTGAG GACCCATGGCTGCTCCGGGTAGGGGAGTGTGATACCCAGGCAGCTTCTGCTGGCAGGGCC CCCAGCCCCACACTTGGCTCCCCCCGGCTGCCTGAGGCCCAGGTGATGCTAGCCTGTGCC CAGAGAGTGGTGGACGGGTGTGAGGTGGCAGCCAGGGCGGCCCGCAGGCCAGAGGCTGTG GCTCGGATCCCACCGCTGCGGAGGGGTGCCACCACGCTGGGTGTGACAACGCCAGCTGTG TCCTGGGGAGATGCTCCCACGGAGGTGGTGGCCTGCTCGGGGAGCCTGAAGGCCTCCCCC ACCAGCAAGAAGGGTCTGGCTCCCAAGGCGGGCTTCCTCCCGAGGCCCAGTGGGGCGGCC CCCCCGGCCCCACCCACGCGGAAGTCCAGCCTGGAGCAGAGGAGCAGCCCGGCCTCGGCC CCTCCGCATGCTGTGAACCCGGCGCGGGTCGGGGCTGCTGCTGTCCTTCGAGGGGAGGAG GAGCCCAGACCCAGCAGCCGGGCTGACCACTCTGTCCCCAGGGCCACGTCCAGCCTGAAG GCCCGGGCCAGCAAGGTAGAAGCAGCACACCGTCTTGCCGGACACGCGTCTCTGGAGCGG TACGAAGGCCTGGCGCACAGCAGCAGCAAGGGCCGGGAAGCCCCTGGGCGGCCTCCCCGG GCTGTACCCAAGCTGGGTGTGCCACCCTCCAGCCCCACACACGGTCCAGCTCCCGCCTGT AGGAGCGGCGCAGCCAAGGCTGTGGGGGCCCCCAAGCCCCCTGTTGGTGGAGGCAAGGGC CGTGGCCTAGTGGCTGGTGGGTCGCGGGCTCTGGGGCCTTCGGTGAAGCTGTCTACGGCC TCTGTGACGGGCAGGAGCCCTGGCGGCCCTGTGGCCGGTCCCAGAGCAGCCCCACGGGCC GGGCCCAGTGTCGGGGCGAAGGCTGGCCGGGGTACCGTCATGGGCACAAAGCAGGCGCTC CGGGCTGCTCACAGCCGCGTCCATGAGCTGTCAGCCAGTGGAGCCCCGGGCCGAGGTGGC TCCTCGTGGGGCTCGGCGGACTCAGACAGCGGCCATGACAGCGGCGTGAACGTGGGGGAG GAGCGGCCACCCACGGGCCCGGCCCTGCCCTCCCCCTACAGCAAGGTGACCGCCCCACGG CGGCCCCAGCGCTACAGCAGCGGCCATGGCAGCGACAACAGCAGCGTGCTGAGTGGAGAG CTGCCGCCCGCCATGGGCCGCACCGCCCTTTTCCACCACAGCGGTGGCAGCAGTGGCTAT GAGAGCCTGCGGCGCGACAGCGAGGCCACCGGCAGCGCCTCCTCCGCCCCTGACTCCATG AGCGAGAGTGGGGCTGCCTCCCCAGGCGCCCGCACCCGCAGCCTCAAGTCCCCCAAGAAG AGGGCCACAGGTCTGCAGCGGCGGCGCCTGATTCCCGCCCCACTGCCCGACACCACTGCC CTGGGCCGTAAGCCCAGCCTCCCCGGGCAGTGGGTGGACCTGCCCCCGCCCCTGGCTGGC TCCCTGAAGGAGCCGTTCGAGATCAAGGTGTACGAGATCGATGACGTGGAGCGCCTTCAG CGGCCCCGCCCCACCCCGAGGGAGGCCCCCACCCAGGGTCTGGCGTGCGTCAGTACAAGG CTGCGGCTGGCGGAGCGCAGGCAGCAGCGGCTGCGGGAGGTGCAGGCCAAGCACAAGCAC CTGTGTGAGGAGCTGGCCGAGACCCAGGGCCGGCTGATGCTGGAGCCTGGCCGCTGGCTG GAGCAGTTTGAGGTGGACCCGGAGCTGGAGCCCGAGTCGGCCGAGTACCTGGCGGCCCTG GAGCGAGCCACGGCGGCCCTGGAGCAGTGCGTGAACCTGTGCAAGGCGCACGTCATGATG GTCACCTGCTTCGACATCAGCGTTGCAGCCAGTGCTGCCATCCCGGGGCCGCAGGAGGTG GACGTCTGA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID	HGNC:20226
Chromosome Location	14
Locus	None
References	Heilig R, Eckenberg R, Petit JL, Fonknechten N, Da Silva C, Cattolico L, Levy M, Barbe V, de Berardinis V, Ureta-Vidal A, Pelletier E, Vico V, Anthouard V, Rowen L, Madan A, Qin S, Sun H, Du H, Pepin K, Artiguenave F, Robert C, Cruaud C, Bruls T, Jaillon O, Friedlander L, Samson G, Brottier P, Cure S, Segurens B, Aniere F, Samain S, Crespeau H, Abbasi N, Aiach N, Boscus D, Dickhoff R, Dors M, Dubois I, Friedman C, Gouyvenoux M, James R, Madan A, Mairey-Estrada B, Mangenot S, Martins N, Menard M, Oztas S, Ratcliffe A, Shaffer T, Trask B, Vacherie B, Bellemere C, Belser C, Besnard-Gonnet M, Bartol-Mavel D, Boutard M, Briez-Silla S, Combette S, Dufosse-Laurent V, Ferron C, Lechaplais C, Louesse C, Muselet D, Magdelenat G, Pateau E, Petit E, Sirvain-Trukniewicz P, Trybou A, Vega-Czarny N, Bataille E, Bluet E, Bordelais I, Dubois M, Dumont C, Guerin T, Haffray S, Hammadi R, Muanga J, Pellouin V, Robert D, Wunderle E, Gauguet G, Roy A, Sainte-Marthe L, Verdier J, Verdier-Discala C, Hillier L, Fulton L, McPherson J, Matsuda F, Wilson R, Scarpelli C, Gyapay G, Wincker P, Saurin W, Quetier F, Waterston R, Hood L, Weissenbach J: The DNA sequence and analysis of human chromosome 14. Nature. 2003 Feb 6;421(6923):601-7. Epub 2003 Jan 1.[12508121 ] Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1999 Oct 29;6(5):337-45.[10574462 ] Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. DNA Res. 2002 Jun 30;9(3):99-106.[12168954 ] Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399.[17974005 ] Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]

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FRCD ID	Name	Exact Mass	Structure
F04722	Acrylamide	71.079

FRCD

Kinesin-like protein KIF26A

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