Ornithine decarboxylase antizyme 3
Name | Ornithine decarboxylase antizyme 3 |
---|---|
Synonyms | AZ3 |
Gene Name | OAZ3 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0037177|Ornithine decarboxylase antizyme 3 MPCKRCRPSVYSLSYIKRGKTRNYLYPIWSPYAYYLYCYKYRITLREKMLPRCYKSITYK EEEDLTLQPRSCLQCSESLVGLQEGKSTEQGNHDQLKELYSAGNLTVLATDPLLHQDPVQ LDFHFRLTSQTSAHWHGLLCDRRLFLDIPYQALDQGNRESLTATLEYVEEKTNVDSVFVN FQNDRNDRGALLRAFSYMGFEVVRPDHPALPPLDNVIFMVYPLERDVGHLPSEPP |
Number of residues | 235 |
Molecular Weight | 27412.93 |
Theoretical pI | 4.67 |
GO Classification |
Functions
ornithine decarboxylase inhibitor activity putrescine transmembrane transporter activity Processes
negative regulation of polyamine transmembrane transport positive regulation of protein catabolic process regulation of cellular amino acid metabolic process spermatogenesis putrescine transport cellular nitrogen compound metabolic process small molecule metabolic process polyamine metabolic process polyamine biosynthetic process Components
nucleus cytosol blood microparticle |
General Function | Putrescine transmembrane transporter activity |
Specific Function | Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells. |
Transmembrane Regions | |
GenBank Protein ID | 5802609 |
UniProtKB ID | Q9UMX2 |
UniProtKB Entry Name | OAZ3_HUMAN |
Cellular Location | Nucleus |
Gene sequence | >lcl|BSEQ0011612|Ornithine decarboxylase antizyme 3 (OAZ3) ATGACCGTGCCCTGGCGGCCAGGAAAGCGACGCATCACTTATAAGGAAGAGGAGGACTTG ACACTCCAGCCCCGTTCCTGCCTCCAGTGCTCCGAGTCCCTAGTAGGCCTCCAGGAGGGC AAAAGCACCGAGCAGGGTAACCACGACCAGCTTAAAGAACTGTATTCGGCTGGGAACTTG ACGGTGCTGGCTACTGACCCCCTGCTCCACCAGGACCCAGTACAGTTAGACTTTCACTTC CGCCTTACCTCCCAGACCTCTGCCCATTGGCACGGCCTTCTCTGTGACCGTCGACTCTTC CTGGATATCCCATATCAGGCCTTGGATCAAGGCAACCGGGAAAGTTTGACTGCAACCCTG GAGTACGTGGAAGAGAAGACAAATGTGGACTCTGTGTTTGTGAACTTCCAGAATGATCGG AACGACAGAGGTGCCCTGCTGCGGGCCTTCAGCTACATGGGCTTTGAGGTGGTCAGACCA GATCACCCTGCCCTCCCTCCCTTGGACAATGTCATCTTTATGGTGTATCCCCTTGAAAGG GATGTTGGCCACCTGCCCAGTGAGCCTCCTTGA |
GenBank Gene ID | AF175296 |
GeneCard ID | None |
GenAtlas ID | OAZ3 |
HGNC ID | HGNC:8097 |
Chromosome Location | 1 |
Locus | 1q21.3 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Ornithine |
132.163 |