Tumor necrosis factor ligand superfamily member 13B
| Name | Tumor necrosis factor ligand superfamily member 13B |
|---|---|
| Synonyms | B lymphocyte stimulator B-cell-activating factor BAFF BLYS Dendritic cell-derived TNF-like molecule TALL-1 TALL1 TNF- and APOL-related leukocyte expressed ligand 1 TNFSF20 ZTNF4 |
| Gene Name | TNFSF13B |
| Organism | Human |
| Amino acid sequence | >lcl|BSEQ0001989|Tumor necrosis factor ligand superfamily member 13B MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCC LTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAP GEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEE KENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETL PNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL |
| Number of residues | 285 |
| Molecular Weight | 31222.48 |
| Theoretical pI | 6.15 |
| GO Classification |
Functions
receptor binding Processes
positive regulation of cell proliferation positive regulation of T cell proliferation signal transduction T cell costimulation tumor necrosis factor-mediated signaling pathway positive regulation of B cell proliferation immune response B cell costimulation B cell homeostasis immunoglobulin secretion cell proliferation positive regulation of germinal center formation Components
cytoplasm extracellular region plasma membrane extracellular space integral component of membrane perinuclear region of cytoplasm |
| General Function | Receptor binding |
| Specific Function | Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. |
| Transmembrane Regions | 47-67 |
| GenBank Protein ID | 4761612 |
| UniProtKB ID | Q9Y275 |
| UniProtKB Entry Name | TN13B_HUMAN |
| Cellular Location | Cell membrane |
| Gene sequence | >lcl|BSEQ0010699|Tumor necrosis factor ligand superfamily member 13B (TNFSF13B) ATGGATGACTCCACAGAAAGGGAGCAGTCACGCCTTACTTCTTGCCTTAAGAAAAGAGAA GAAATGAAACTGAAGGAGTGTGTTTCCATCCTCCCACGGAAGGAAAGCCCCTCTGTCCGA TCCTCCAAAGACGGAAAGCTGCTGGCTGCAACCTTGCTGCTGGCACTGCTGTCTTGCTGC CTCACGGTGGTGTCTTTCTACCAGGTGGCCGCCCTGCAAGGGGACCTGGCCAGCCTCCGG GCAGAGCTGCAGGGCCACCACGCGGAGAAGCTGCCAGCAGGAGCAGGAGCCCCCAAGGCC GGCCTGGAGGAAGCTCCAGCTGTCACCGCGGGACTGAAAATCTTTGAACCACCAGCTCCA GGAGAAGGCAACTCCAGTCAGAACAGCAGAAATAAGCGTGCCGTTCAGGGTCCAGAAGAA ACAGGATCTTACACATTTGTTCCATGGCTTCTCAGCTTTAAAAGGGGAAGTGCCCTAGAA GAAAAAGAGAATAAAATATTGGTCAAAGAAACTGGTTACTTTTTTATATATGGTCAGGTT TTATATACTGATAAGACCTACGCCATGGGACATCTAATTCAGAGGAAGAAGGTCCATGTC TTTGGGGATGAATTGAGTCTGGTGACTTTGTTTCGATGTATTCAAAATATGCCTGAAACA CTACCCAATAATTCCTGCTATTCAGCTGGCATTGCAAAACTGGAAGAAGGAGATGAACTC CAACTTGCAATACCAAGAGAAAATGCACAAATATCACTGGATGGAGATGTCACATTTTTT GGTGCATTGAAACTGCTGTGA |
| GenBank Gene ID | AF136293 |
| GeneCard ID | None |
| GenAtlas ID | TNFSF13B |
| HGNC ID | HGNC:11929 |
| Chromosome Location | 13 |
| Locus | 13q32-34 |
| References |
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Related FRC
| FRCD ID | Name | Exact Mass | Structure |
|---|---|---|---|
1,4-Dioxane |
88.106 |