Lethal(3)malignant brain tumor-like protein 1

NameLethal(3)malignant brain tumor-like protein 1
SynonymsH-l(3)mbt KIAA0681 L(3)mbt protein homolog L3MBT L3MBTL L3MBTL1
Gene NameL3MBTL1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037223|Lethal(3)malignant brain tumor-like protein 1
MRRREGHGTDSEMGQGPVRESQSSDPPALQFRISEYKPLNMAGVEQPPSPELRQEGVTEY
EDGGAPAGDGEAGPQQAEDHPQNPPEDPNQDPPEDDSTCQCQACGPHQAAGPDLGSSNDG
CPQLFQERSVIVENSSGSTSASELLKPMKKRKRREYQSPSEEESEPEAMEKQEEGKDPEG
QPTASTPESEEWSSSQPATGEKKECWSWESYLEEQKAITAPVSLFQDSQAVTHNKNGFKL
GMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTG
HKLQPPKGYKEEEFSWSQYLRSTRAQAAPKHLFVSQSHSPPPLGFQVGMKLEAVDRMNPS
LVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPD
NFCWEKYLEETGASAVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIK
IHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLGPREPSSASPGGCPPLSYRSLP
HTRTSKYSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDSEASAR
KKNLSGFSPRKKPRHHGRIGRPPKYRKIPQEDFQTLTPDVVHQSLFMSALSAHPDRSLSV
CWEQHCKLLPGVAGISASTVAKWTIDEVFGFVQTLTGCEDQARLFKDEMIDGEAFLLLTQ
ADIVKIMSVKLGPALKIYNAILMFKNADDTLK
Number of residues752
Molecular Weight83882.985
Theoretical pI6.04
GO Classification
Functions
    transcription factor activity, sequence-specific DNA binding
zinc ion binding
histone binding
chromatin binding
methylated histone binding
nucleosomal histone binding
identical protein binding
nucleosome binding
SAM domain binding
Processes
    regulation of megakaryocyte differentiation
negative regulation of transcription, DNA-templated
hemopoiesis
regulation of cell cycle
chromatin modification
transcription, DNA-templated
regulation of mitotic nuclear division
Components
    nucleus
plasma membrane
condensed chromosome
chromatin
nucleoplasm
General FunctionZinc ion binding
Specific FunctionPolycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ9Y468
UniProtKB Entry NameLMBL1_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0021350|Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
ATGAGGCGAAGAGAGGGCCATGGCACCGACTCCGAGATGGGTCAAGGACCCGTACGGGAG
TCGCAATCCTCAGACCCTCCCGCGCTCCAGTTCCGGATAAGCGAGTATAAGCCGCTGAAC
ATGGCGGGAGTGGAGCAGCCCCCGAGCCCCGAGCTGCGGCAGGAAGGCGTGACCGAATAC
GAAGATGGCGGGGCCCCGGCGGGAGATGGCGAGGCGGGCCCCCAACAGGCGGAGGACCAC
CCCCAGAATCCTCCAGAAGATCCCAATCAGGACCCCCCAGAGGATGATAGCACCTGTCAG
TGCCAGGCGTGCGGGCCTCACCAAGCCGCGGGTCCAGATCTTGGTTCCTCTAATGATGGC
TGCCCTCAGCTGTTCCAGGAGCGGTCAGTCATAGTGGAGAACTCCTCAGGCTCTACCAGC
GCTTCTGAGCTCCTCAAACCCATGAAGAAGAGGAAGCGCAGGGAATACCAGAGCCCATCA
GAGGAGGAGTCGGAGCCAGAGGCCATGGAGAAGCAAGAAGAAGGAAAGGACCCAGAGGGA
CAACCCACTGCTAGCACCCCAGAGAGTGAGGAGTGGAGCAGCAGCCAGCCTGCAACAGGT
GAGAAGAAGGAATGCTGGTCGTGGGAGTCCTACCTAGAGGAGCAGAAGGCCATTACTGCT
CCAGTCAGCCTCTTCCAGGACTCCCAGGCAGTCACTCACAACAAGAATGGCTTCAAACTG
GGCATGAAGTTGGAAGGCATTGACCCTCAACACCCGTCCATGTACTTCATCCTCACCGTG
GCTGAGGTATGTGGCTATCGCCTACGCCTGCACTTTGATGGGTATTCTGAGTGCCATGAC
TTCTGGGTCAATGCCAACTCCCCTGACATTCACCCTGCTGGCTGGTTCGAGAAGACGGGC
CACAAGCTGCAGCCTCCCAAAGGTTACAAGGAGGAGGAGTTCAGCTGGAGCCAGTACCTG
CGCAGCACAAGAGCTCAGGCTGCCCCCAAGCACCTGTTTGTGAGCCAGAGCCACAGTCCC
CCACCCCTGGGCTTCCAGGTGGGCATGAAGCTGGAGGCTGTTGACCGCATGAACCCGTCC
CTTGTCTGCGTGGCCAGTGTGACCGATGTGGTGGACAGCCGCTTCCTGGTGCACTTTGAC
AACTGGGATGATACTTATGACTACTGGTGTGATCCCAGCAGCCCCTACATCCACCCAGTG
GGCTGGTGCCAGAAGCAAGGAAAGCCCCTCACCCCTCCACAAGACTACCCAGACCCTGAT
AACTTCTGTTGGGAGAAATATCTGGAAGAAACTGGGGCCTCTGCTGTCCCCACCTGGGCC
TTCAAGGTGCGACCCCCTCACAGCTTCCTGGTCAATATGAAGCTGGAGGCTGTGGACCGC
AGGAACCCAGCCCTGATTCGCGTGGCCAGCGTGGAGGATGTGGAGGACCATCGGATAAAG
ATCCACTTTGATGGCTGGAGTCATGGCTATGATTTCTGGATCGACGCTGACCACCCAGAC
ATCCACCCTGCCGGCTGGTGCTCCAAGACAGGACATCCCCTGCAGCCTCCTCTCGGACCC
AGAGAGCCCAGCTCTGCCTCCCCTGGGGGCTGTCCCCCTCTCAGCTATAGGAGCCTGCCC
CACACTAGGACCTCCAAATACAGCTTTCACCACCGGAAGTGCCCCACTCCTGGTTGCGAC
GGCTCTGGCCATGTCACAGGCAAGTTCACAGCTCACCATTGCCTCTCAGGCTGCCCACTG
GCTGAGAGGAACCAGAGCCGGCTGAAAGCGGAGCTGTCTGACTCGGAGGCCTCAGCCCGC
AAGAAGAACCTCTCAGGCTTCTCCCCAAGGAAGAAGCCTCGCCATCACGGCCGAATTGGA
CGCCCTCCGAAGTATCGAAAGATTCCGCAGGAAGATTTCCAGACCCTCACGCCCGATGTC
GTGCACCAGTCCCTCTTCATGTCAGCCCTGTCGGCCCACCCTGACCGCTCACTCTCAGTG
TGCTGGGAGCAGCACTGCAAGCTCCTGCCAGGAGTAGCGGGCATCTCAGCCTCGACAGTC
GCCAAGTGGACCATCGATGAGGTCTTCGGCTTTGTTCAGACCCTGACAGGTTGTGAGGAC
CAAGCACGCCTCTTCAAAGACGAGGCAAGAATAGTCAGAGTGACCCATGTATCTGGGAAG
ACTCTAGTCTGGACTGTGGCCCAGCTTGGGGACCTTGTGTGCTCAGATCATCTTCAGGAA
GGAAAAGGCATCCTGGAGACAGGAGTCCATTCACTCCTCTGCTCTCTACCCACTCATTTG
CTTGCCAAACTTAGCTTTGCCAGTGATAGTCAATATTAA
GenBank Gene IDU89358
GeneCard IDNone
GenAtlas IDL3MBTL
HGNC IDHGNC:15905
Chromosome Location20
Locus20q13.12
References
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