Metal-response element-binding transcription factor 2

NameMetal-response element-binding transcription factor 2
SynonymshPCl2 Metal regulatory transcription factor 2 Metal-response element DNA-binding protein M96 PCL2 Polycomb-like protein 2
Gene NameMTF2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009235|Metal-response element-binding transcription factor 2
MRDSTGAGNSLVHKRSPLRRNQKTPTSLTKLSLQDGHKAKKPACKFEEGQDVLARWSDGL
FYLGTIKKINILKQSCFIIFEDSSKSWVLWKDIQTGATGSGEMVCTICQEEYSEAPNEMV
ICDKCGQGYHQLCHTPHIDCSVIDSDEKWLCRQCVFATTTKRGGALKKGPNAKALQVMKQ
TLPYSVADLEWDAGHKTNVQQCYCYCGGPGDWYLKMLQCCKCKQWFHEACVQCLQKPMLF
GDRFYTFICSVCSSGPEYLKRLPLQWVDIAHLCLYNLSVIHKKKYFDSELELMTYINENW
DRLHPGELADTPKSERYEHVLEALNDYKTMFMSGKEIKKKKHLFGLRIRVPPVPPNVAFK
AEKEPEGTSHEFKIKGRKASKPISDSREVSNGIEKKGKKKSVGRPPGPYTRKMIQKTAEP
LLDKESISENPTLDLPCSIGRTEGTAHSSNTSDVDFTGASSAKETTSSSISRHYGLSDSR
KRTRTGRSWPAAIPHLRRRRGRLPRRALQTQNSEIVKDDEGKEDYQFDELNTEILNNLAD
QELQLNHLKNSITSYFGAAGRIACGEKYRVLARRVTLDGKVQYLVEWEGATAS
Number of residues593
Molecular Weight67105.08
Theoretical pINone
GO Classification
Functions
    zinc ion binding
DNA binding
methylated histone binding
Processes
    negative regulation of gene expression, epigenetic
regulation of gene expression, epigenetic
negative regulation of histone H3-K27 methylation
gene expression
positive regulation of histone H3-K27 methylation
segment specification
positive regulation of transcription from RNA polymerase II promoter
stem cell differentiation
negative regulation of transcription from RNA polymerase II promoter
stem cell population maintenance
chromatin modification
Components
    cytoplasm
ESC/E(Z) complex
nucleus
nucleoplasm
General FunctionZinc ion binding
Specific FunctionPolycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ9Y483
UniProtKB Entry NameMTF2_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013687|Metal-response element-binding transcription factor 2 (MTF2)
ATGGTCTGTACAATATGTCAAGAAGAGTATTCAGAAGCTCCCAATGAAATGGTTATATGT
GACAAGTGTGGCCAAGGATATCATCAGTTGTGTCACACACCTCATATTGATTCCAGTGTG
ATTGATTCAGATGAAAAATGGCTCTGTCGGCAGTGTGTTTTTGCAACAACAACAAAGAGG
GGTGGTGCACTTAAGAAAGGACCAAATGCCAAAGCATTGCAAGTCATGAAGCAGACATTA
CCCTATAGTGTGGCAGACCTTGAATGGGATGCAGGTCATAAAACCAATGTCCAGCAGTGT
TACTGCTATTGTGGAGGCCCTGGAGACTGGTATTTGAAGATGCTACAGTGCTGCAAATGT
AAGCAGTGGTTTCATGAGGCTTGTGTGCAATGCCTTCAAAAGCCAATGCTATTTGGAGAC
AGATTTTATACGTTTATATGCTCTGTCTGCAGTTCTGGACCAGAATACCTCAAACGTCTA
CCATTACAGTGGGTAGATATAGCACACCTATGCCTTTACAACCTAAGTGTTATTCATAAG
AAGAAATACTTTGATTCTGAACTTGAGCTTATGACATACATTAATGAAAACTGGGATAGA
TTGCACCCTGGAGAGCTGGCAGACACACCAAAATCTGAAAGATATGAGCATGTTCTGGAG
GCATTAAATGATTACAAGACCATGTTTATGTCTGGGAAAGAAATAAAGAAGAAGAAGCAT
TTGTTTGGGTTGCGAATTCGTGTTCCTCCTGTGCCACCAAATGTGGCTTTCAAAGCAGAG
AAAGAACCTGAAGGAACATCTCATGAATTTAAAATTAAAGGCAGAAAGGCATCCAAACCT
ATATCTGATTCAAGGGAAGTAAGCAATGGCATAGAAAAAAAAGGAAAGAAAAAATCTGTA
GGTCGTCCACCTGGCCCATATACAAGAAAAATGATTCAAAAAACTGCTGAGCCACTTTTG
GATAAGGAATCAATTTCAGAGAATCCTACTTTGGATTTACCTTGTTCTATAGGGAGAACT
GAGGGAACTGCACATTCATCCAATACCTCAGATGTGGATTTCACGGGTGCTTCCAGTGCA
AAAGAAACTACCTCGTCTAGCATTTCCAGGCATTATGGATTATCTGACTCCAGAAAAAGA
ACGCGTACAGGAAGATCTTGGCCTGCTGCAATACCACATTTGCGGAGAAGAAGAGGTCGT
CTTCCAAGAAGAGCACTCCAGACTCAGAACTCAGAAATTGTAAAAGATGATGAAGGCAAA
GAAGATTATCAGTTTGATGAACTCAACACAGAGATTCTGAATAACTTAGCAGATCAGGAG
TTACAACTCAATCATCTAAAGAACTCCATTACCAGTTATTTTGGTGCTGCAGGTAGAATA
GCATGTGGCGAAAAATACCGAGTTTTGGCACGTCGGGTGACACTTGATGGAAAGGTGCAG
TATCTTGTGGAATGGGAAGGAGCAACTGCATCCTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:29535
Chromosome Location1
LocusNone
References
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  2. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31.[18669648 ]
  3. Musselman CA, Avvakumov N, Watanabe R, Abraham CG, Lalonde ME, Hong Z, Allen C, Roy S, Nunez JK, Nickoloff J, Kulesza CA, Yasui A, Cote J, Kutateladze TG: Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. Nat Struct Mol Biol. 2012 Dec;19(12):1266-72. doi: 10.1038/nsmb.2435. Epub 2012 Nov 11.[23142980 ]
  4. Qin S, Guo Y, Xu C, Bian C, Fu M, Gong S, Min J: Tudor domains of the PRC2 components PHF1 and PHF19 selectively bind to histone H3K36me3. Biochem Biophys Res Commun. 2013 Jan 11;430(2):547-53. doi: 10.1016/j.bbrc.2012.11.116. Epub 2012 Dec 7.[23228662 ]
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