Kinesin-like protein KIF3A

NameKinesin-like protein KIF3A
SynonymsKIF3 Microtubule plus end-directed kinesin motor 3A
Gene NameKIF3A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009160|Kinesin-like protein KIF3A
MPINKSEKPESCDNVKVVVRCRPLNEREKSMCYKQAVSVDEMRGTITVHKTDSSNEPPKT
FTFDTVFGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAIPELR
GIIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVY
IKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGIDGNMH
VRMGKLHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNS
KLTRLLQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALL
RQFQKEIEELKKKLEEGEEISGSDISGSEEDDDEEGEVGEDGEKRKKRRGKKKVSPDKMI
EMQAKIDEERKALETKLDMEEEERNKARAELEKREKDLLKAQQEHQSLLEKLSALEKKVI
VGGVDLLAKAEEQEKLLEESNMELEERRKRAEQLRRELEEKEQERLDIEEKYTSLQEEAQ
GKTKKLKKVWTMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPRDY
QEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQTPVPDKKEKDPFEVDLSHVYLAYTEESL
RQSLMKLERPRTSKGKARPKTGRRKRSAKPETVIDSLLQ
Number of residues699
Molecular Weight80040.19
Theoretical pINone
GO Classification
Functions
    spectrin binding
ATP binding
ATP-dependent microtubule motor activity, plus-end-directed
Processes
    membrane organization
antigen processing and presentation of exogenous peptide antigen via MHC class II
organelle organization
microtubule-based movement
cilium assembly
plus-end-directed vesicle transport along microtubule
blood coagulation
cilium morphogenesis
Components
    cytosol
ciliary tip
extracellular exosome
kinesin II complex
primary cilium
centrosome
microtubule cytoskeleton
microtubule
General FunctionSpectrin binding
Specific FunctionMicrotubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity).
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ9Y496
UniProtKB Entry NameKIF3A_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0017709|Kinesin-like protein KIF3A (KIF3A)
ATGCCGATCAATAAATCAGAGAAGCCAGAAAGCTGCGATAATGTGAAGGTTGTTGTTAGG
TGCCGGCCCCTCAATGAGAGAGAGAAATCAATGTGCTACAAACAGGCTGTCAGTGTGGAT
GAGATGAGGGGAACTATCACTGTACATAAGACTGATTCTTCCAATGAACCTCCAAAGACA
TTTACTTTTGATACTGTTTTTGGACCAGAGAGTAAACAACTTGATGTTTATAACTTAACT
GCAAGACCTATTATTGATTCTGTACTTGAAGGCTACAATGGGACTATTTTTGCATATGGA
CAAACCGGAACAGGCAAAACTTTTACCATGGAAGGTGTTCGAGCTATTCCTGAACTTAGA
GGAATAATTCCCAATTCATTTGCTCACATATTTGGTCATATTGCAAAAGCGGAGGGTGAT
ACAAGATTTTTGGTTCGAGTGTCTTATTTGGAAATATATAATGAAGAAGTTCGTGACCTT
TTGGGCAAGGATCAGACACAAAGGTTAGAGGTTAAAGAAAGACCTGATGTGGGAGTTTAT
ATCAAAGATTTATCAGCTTATGTGGTAAATAATGCTGATGATATGGATAGAATTATGACG
CTAGGCCACAAAAATCGTTCTGTTGGTGCAACTAATATGAACGAACATAGTTCCCGTTCC
CATGCCATCTTTACAATTACTATAGAATGCAGTGAAAAAGGCATTGATGGTAACATGCAT
GTCAGGATGGGGAAGCTCCATCTTGTAGATCTTGCTGGTTCAGAAAGACAGGCAAAAACT
GGAGCTACTGGACAGCGCCTAAAGGAAGCTACAAAAATCAATCTTTCACTTTCCACCCTT
GGTAATGTAATTTCTGCCTTGGTTGATGGAAAAAGCACTCATGTGCCTTATCGTAACTCT
AAACTGACTCGTCTTCTTCAGGATTCCTTAGGAGGAAATTCAAAAACCATGATGTGTGCA
AATATTGGGCCAGCAGATTACAATTATGATGAAACTATCAGTACATTACGGTATGCCAAT
CGTGCTAAGAATATTAAAAATAAAGCTAGAATTAATGAAGATCCAAAGGATGCTTTGCTG
CGTCAGTTCCAGAAAGAAATAGAAGAACTGAAAAAGAAGCTTGAAGAAGGAGAAGAAATA
TCAGGCTCTGATATCAGTGGGTCAGAGGAAGATGATGATGAAGAGGGTGAGGTTGGAGAA
GATGGAGAGAAAAGGAAAAAAAGAAGGGGCAGTAGCAGCAGCAGTAGTTCAGACTCCACA
TGTTCTGTCATAGAGAAACCTCTGGATAAGTTCTTGCCTAATCAAGCAGGAAAAAAGAAA
GTCTCCCCAGACAAGATGATTGAAATGCAAGCAAAAATTGATGAGGAGAGAAAAGCACTT
GAAACAAAGCTCGACATGGAAGAAGAAGAAAGAAACAAGGCTAGAGCTGAATTAGAGAAA
CGGGAAAAAGATCTTCTTAAAGCCCAACAAGAGCATCAGTCTTTGCTGGAAAAATTATCT
GCCCTGGAAAAGAAGGTAATTGTTGGTGGGGTTGACTTGTTGGCCAAAGCTGAGGAACAA
GAGAAACTTCTTGAAGAATCTAACATGGAACTGGAAGAAAGGAGGAAAAGAGCAGAGCAA
CTTCGCAGAGAACTTGAGGAAAAAGAGCAAGAACGCTTGGATATTGAAGAAAAATATACC
AGTTTGCAAGAGGAAGCACAGGGAAAGACCAAGAAGTTAAAGAAAGTTTGGACTATGCTG
ATGGCTGCAAAGTCAGAGATGGCTGATCTCCAACAAGAACATCAGAGGGAAATTGAAGGC
CTACTGGAGAACATTCGGCAACTTAGCCGGGAGCTTCGACTTCAGATGCTTATTATTGAT
AACTTTATACCTCGGGATTATCAGGAAATGATTGAAAACTATGTCCATTGGAATGAAGAC
ATAGGAGAATGGCAGCTAAAATGTGTTGCTTATACAGGAAATAACATGAGGAAGCAAACC
CCAGTACCTGATAAAAAGGAGAAAGATCCCTTTGAGGTGGACCTTTCTCACGTGTATCTT
GCCTATACTGAGGAGAGTCTGCGTCAGTCTTTGATGAAACTAGAAAGACCACGAACTTCA
AAGGGGAAAGCAAGGCCAAAGACAGGGAGAAGAAAGCGTTCTGCAAAGCCTGAAACTGTA
ATTGACTCTTTACTGCAGTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:6319
Chromosome Location5
LocusNone
References
  1. Whitehead JL, Wang SY, Bost-Usinger L, Hoang E, Frazer KA, Burnside B: Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina. Exp Eye Res. 1999 Nov;69(5):491-503.[10548469 ]
  2. Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM: The DNA sequence and comparative analysis of human chromosome 5. Nature. 2004 Sep 16;431(7006):268-74.[15372022 ]
  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31.[18669648 ]
  4. Kinzel D, Boldt K, Davis EE, Burtscher I, Trumbach D, Diplas B, Attie-Bitach T, Wurst W, Katsanis N, Ueffing M, Lickert H: Pitchfork regulates primary cilia disassembly and left-right asymmetry. Dev Cell. 2010 Jul 20;19(1):66-77. doi: 10.1016/j.devcel.2010.06.005.[20643351 ]
  5. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475.[20068231 ]
  6. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17.[21269460 ]
  7. Uusi-Rauva K, Kyttala A, van der Kant R, Vesa J, Tanhuanpaa K, Neefjes J, Olkkonen VM, Jalanko A: Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments. Cell Mol Life Sci. 2012 Jun;69(12):2075-89. doi: 10.1007/s00018-011-0913-1. Epub 2012 Jan 20.[22261744 ]
  8. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]

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