Histamine H3 receptor
Name | Histamine H3 receptor |
---|---|
Synonyms | G-protein coupled receptor 97 GPCR97 H3R |
Gene Name | HRH3 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0001927|Histamine H3 receptor MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR RAFTKLLCPQKLKIQPHSSLEHCWK |
Number of residues | 445 |
Molecular Weight | 48670.81 |
Theoretical pI | 9.53 |
GO Classification |
Functions
histamine receptor activity histamine binding Processes
negative regulation of adenylate cyclase activity negative regulation of glutamate secretion regulation of norepinephrine secretion negative regulation of serotonin secretion neurotransmitter secretion sensory perception of chemical stimulus G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger cognition Components
plasma membrane integral component of plasma membrane |
General Function | Histamine receptor activity |
Specific Function | The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization. |
Transmembrane Regions | 40-60 71-91 109-129 157-177 197-217 360-380 396-416 |
GenBank Protein ID | 5031291 |
UniProtKB ID | Q9Y5N1 |
UniProtKB Entry Name | HRH3_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0016270|Histamine H3 receptor (HRH3) ATGGAGCGCGCGCCGCCCGACGGGCCGCTGAACGCTTCGGGGGCGCTGGCGGGCGAGGCG GCGGCGGCGGGCGGGGCGCGCGGCTTCTCGGCAGCCTGGACCGCGGTGCTGGCCGCGCTC ATGGCGCTGCTCATCGTGGCCACGGTGCTGGGCAACGCGCTGGTCATGCTCGCCTTCGTG GCCGACTCGAGCCTCCGCACCCAGAACAACTTCTTCCTGCTCAACCTCGCCATCTCCGAC TTCCTCGTCGGCGCCTTCTGCATCCCACTGTATGTACCCTACGTGCTGACAGGCCGCTGG ACCTTCGGCCGGGGCCTCTGCAAGCTGTGGCTGGTAGTGGACTACCTGCTGTGCACCTCC TCTGCCTTCAACATCGTGCTCATCAGCTACGACCGCTTCCTGTCGGTCACCCGAGCGGTC TCATACCGGGCCCAGCAGGGTGACACGCGGCGGGCAGTGCGGAAGATGCTGCTGGTGTGG GTGCTGGCCTTCCTGCTGTACGGACCAGCCATCCTGAGCTGGGAGTACCTGTCCGGGGGC AGCTCCATCCCCGAGGGCCACTGCTATGCCGAGTTCTTCTACAACTGGTACTTCCTCATC ACGGCTTCCACCCTGGAGTTCTTTACGCCCTTCCTCAGCGTCACCTTCTTTAACCTCAGC ATCTACCTGAACATCCAGAGGCGCACCCGCCTCCGGCTGGATGGGGCTCGAGAGGCAGCC GGCCCCGAGCCCCCTCCCGAGGCCCAGCCCTCACCACCCCCACCGCCTGGCTGCTGGGGC TGCTGGCAGAAGGGGCACGGGGAGGCCATGCCGCTGCACAGGTATGGGGTGGGTGAGGCG GCCGTAGGCGCTGAGGCCGGGGAGGCGACCCTCGGGGGTGGCGGTGGGGGCGGCTCCGTG GCTTCACCCACCTCCAGCTCCGGCAGCTCCTCGAGGGGCACTGAGAGGCCGCGCTCACTC AAGAGGGGCTCCAAGCCGTCGGCGTCCTCGGCCTCGCTGGAGAAGCGCATGAAGATGGTG TCCCAGAGCTTCACCCAGCGCTTTCGGCTGTCTCGGGACAGGAAAGTGGCCAAGTCGCTG GCCGTCATCGTGAGCATCTTTGGGCTCTGCTGGGCCCCATACACGCTGCTGATGATCATC CGGGCCGCCTGCCATGGCCACTGCGTCCCTGACTACTGGTACGAAACCTCCTTCTGGCTC CTGTGGGCCAACTCGGCTGTCAACCCTGTCCTCTACCCTCTGTGCCACCACAGCTTCCGC CGGGCCTTCACCAAGCTGCTCTGCCCCCAGAAGCTCAAAATCCAGCCCCACAGCTCCCTG GAGCACTGCTGGAAGTGA |
GenBank Gene ID | AF140538 |
GeneCard ID | None |
GenAtlas ID | HRH3 |
HGNC ID | HGNC:5184 |
Chromosome Location | 20 |
Locus | 20q13.33 |
References |
|
Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Mirtazapine |
265.36 |
||
Cyproheptadine |
287.406 |
||
Donepezil |
379.5 |
||
Diphenhydramine |
255.361 |
||
Nantenine |
339.391 |
||
Dimethylamine |
45.085 |
||
Diethylamine |
73.139 |
||
Benzene |
78.114 |