Calcium-activated potassium channel subunit beta-2

NameCalcium-activated potassium channel subunit beta-2
SynonymsBK channel subunit beta-2 BKbeta2 Calcium-activated potassium channel, subfamily M subunit beta-2 Charybdotoxin receptor subunit beta-2 Hbeta2 Hbeta3 K(VCA)beta-2 Maxi K channel subunit beta-2 Slo-beta-2
Gene NameKCNMB2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0012228|Calcium-activated potassium channel subunit beta-2
MFIWTSGRTSSSYRHDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMVCSIM
MYFLLGITLLRSYMQSVWTEESQCTLLNASITETFNCSFSCGPDCWKLSQYPCLQVYVNL
TSSGEKLLLYHTEETIKINQKCSYIPKCGKNFEESMSLVNVVMENFRKYQHFSCYSDPEG
NQKSVILTKLYSSNVLFHSLFWPTCMMAGGVAIVAMVKLTQYLSLLCERIQRINR
Number of residues235
Molecular Weight27129.37
Theoretical pI8.47
GO Classification
Functions
    potassium channel regulator activity
ion channel inhibitor activity
calcium-activated potassium channel activity
Processes
    potassium ion transmembrane transport
neuronal action potential
blood coagulation
action potential
potassium ion transport
detection of calcium ion
synaptic transmission
regulation of vasoconstriction
Components
    plasma membrane
voltage-gated potassium channel complex
integral component of plasma membrane
General FunctionPotassium channel regulator activity
Specific FunctionRegulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.
Transmembrane Regions47-67 195-215
GenBank Protein ID
UniProtKB IDQ9Y691
UniProtKB Entry NameKCMB2_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0012229|Calcium-activated potassium channel subunit beta-2 (KCNMB2)
ATGTTTATATGGACCAGTGGCCGGACCTCTTCATCTTATAGACATGATGAAAAAAGAAAT
ATTTACCAGAAAATCAGGGACCATGACCTCCTGGACAAAAGGAAAACAGTCACAGCACTG
AAGGCAGGAGAGGACCGAGCTATTCTCCTGGGACTGGCTATGATGGTGTGCTCCATCATG
ATGTATTTTCTGCTGGGAATCACACTCCTGCGCTCATACATGCAGAGCGTGTGGACCGAA
GAGTCTCAATGCACCTTGCTGAATGCGTCCATCACGGAAACATTTAATTGCTCCTTCAGC
TGTGGTCCAGACTGCTGGAAACTTTCTCAGTACCCCTGCCTCCAGGTGTACGTTAACCTG
ACTTCTTCCGGGGAAAAGCTCCTCCTCTACCACACAGAAGAGACAATAAAAATCAATCAG
AAGTGCTCCTATATACCTAAATGTGGAAAAAATTTTGAAGAATCCATGTCCCTGGTGAAT
GTTGTCATGGAAAACTTCAGGAAGTATCAACACTTCTCCTGCTATTCTGACCCAGAAGGA
AACCAGAAGAGTGTTATCCTAACAAAACTCTACAGTTCCAACGTGCTGTTCCATTCACTC
TTCTGGCCAACCTGTATGATGGCTGGGGGTGTGGCAATTGTTGCCATGGTGAAACTTACA
CAGTACCTCTCCCTACTATGTGAGAGGATCCAACGGATCAATAGATAA
GenBank Gene IDAF099137
GeneCard IDNone
GenAtlas IDKCNMB2
HGNC IDHGNC:6286
Chromosome Location3
Locus3q26.2-q27.1
References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]
  2. Wallner M, Meera P, Toro L: Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4137-42.[10097176 ]
  3. Brenner R, Jegla TJ, Wickenden A, Liu Y, Aldrich RW: Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. J Biol Chem. 2000 Mar 3;275(9):6453-61.[10692449 ]
  4. Xia XM, Ding JP, Lingle CJ: Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells. J Neurosci. 1999 Jul 1;19(13):5255-64.[10377337 ]
  5. Meera P, Wallner M, Toro L: A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5562-7.[10792058 ]
  6. Xia XM, Ding JP, Lingle CJ: Inactivation of BK channels by the NH2 terminus of the beta2 auxiliary subunit: an essential role of a terminal peptide segment of three hydrophobic residues. J Gen Physiol. 2003 Feb;121(2):125-48.[12566540 ]
  7. Orio P, Rojas P, Ferreira G, Latorre R: New disguises for an old channel: MaxiK channel beta-subunits. News Physiol Sci. 2002 Aug;17:156-61.[12136044 ]
  8. Bentrop D, Beyermann M, Wissmann R, Fakler B: NMR structure of the "ball-and-chain" domain of KCNMB2, the beta 2-subunit of large conductance Ca2+- and voltage-activated potassium channels. J Biol Chem. 2001 Nov 9;276(45):42116-21. Epub 2001 Aug 21.[11517232 ]

Related FRC

FRCD ID Name Exact Mass Structure




F04705



Charybdotoxin


4324.011




F04707



Iberiotoxin


2097.393




F04973



Aflatrem


501.667




F04980



Penitrem B


583.769




F04981



Penitrem C


602.212




F05018



Paspalicine


417.549




F05021



Verruculogen


511.575




F04979



Penitrem A


634.21




F04993



Paspalinine


433.548




F05017



Paspalitrem A


501.667




F05019



Paxilline


435.564