Cysteine desulfurase, mitochondrial
Name | Cysteine desulfurase, mitochondrial |
---|---|
Synonyms | 2.8.1.7 NIFS |
Gene Name | NFS1 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0000301|Cysteine desulfurase, mitochondrial MLLRAAWRRAAVAVTAAPGPKPAAPTRGLRLRVGDRAPQSAVPADTAAAPEVGPVLRPLY MDVQATTPLDPRVLDAMLPYLINYYGNPHSRTHAYGWESEAAMERARQQVASLIGADPRE IIFTSGATESNNIAIKGVARFYRSRKKHLITTQTEHKCVLDSCRSLEAEGFQVTYLPVQK SGIIDLKELEAAIQPDTSLVSVMTVNNEIGVKQPIAEIGRICSSRKVYFHTDAAQAVGKI PLDVNDMKIDLMSISGHKIYGPKGVGAIYIRRRPRVRVEALQSGGGQERGMRSGTVPTPL VVGLGAACEVAQQEMEYDHKRISKLSERLIQNIMKSLPDVVMNGDPKHHYPGCINLSFAY VEGESLLMALKDVALSSGSACTSASLEPSYVLRAIGTDEDLAHSSIRFGIGRFTTEEEVD YTVEKCIQHVKRLREMSPLWEMVQDGIDLKSIKWTQH |
Number of residues | 457 |
Molecular Weight | 50195.21 |
Theoretical pI | 8.45 |
GO Classification |
Functions
protein homodimerization activity pyridoxal phosphate binding metal ion binding iron-sulfur cluster binding cysteine desulfurase activity Processes
protein complex assembly iron incorporation into metallo-sulfur cluster small molecule metabolic process Mo-molybdopterin cofactor biosynthetic process molybdopterin cofactor biosynthetic process sulfur amino acid metabolic process vitamin metabolic process water-soluble vitamin metabolic process [2Fe-2S] cluster assembly Components
cytosol nucleolus cytoplasm nucleoplasm mitochondrion intracellular membrane-bounded organelle nucleus mitochondrial matrix |
General Function | Pyridoxal phosphate binding |
Specific Function | Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor. |
Transmembrane Regions | |
GenBank Protein ID | 24042327 |
UniProtKB ID | Q9Y697 |
UniProtKB Entry Name | NFS1_HUMAN |
Cellular Location | Mitochondrion |
Gene sequence | >lcl|BSEQ0009970|Cysteine desulfurase, mitochondrial (NFS1) ATGCTGCTCCGAGCCGCTTGGAGGCGGGCGGCAGTGGCGGTGACAGCGGCTCCAGGGCCG AAGCCCGCGGCGCCCACTCGGGGGCTGCGCCTGCGCGTTGGAGACCGTGCTCCTCAGTCT GCGGTTCCCGCAGATACAGCCGCTGCCCCGGAGGTGGGGCCAGTGCTGCGACCTCTCTAT ATGGATGTGCAAGCTACAACTCCTCTGGACCCCCGGGTGCTTGATGCCATGCTCCCTTAC CTAATCAACTACTATGGGAACCCACACTCCCGGACACATGCTTATGGCTGGGAGAGTGAG GCAGCCATGGAACGTGCTCGTCAGCAAGTAGCATCTCTGATTGGAGCTGATCCTCGTGAG ATCATTTTTACTAGTGGTGCTACTGAATCCAACAACATAGCAATTAAGGAACTAGAGGCT GCTATCCAGCCAGATACTAGCCTGGTGTCAGTCATGACTGTGAACAATGAGATTGGAGTG AAGCAGCCTATTGCAGAAATAGGGCGGATTTGCAGTTCCAGAAAGGTATATTTCCATACT GATGCAGCCCAGGCTGTTGGAAAAATCCCACTTGATGTCAATGACATGAAAATTGATCTC ATGAGCATTAGTGGTCACAAAATCTACGGTCCCAAAGGGGTTGGTGCCATCTACATCCGT CGCCGGCCCCGTGTGCGTGTGGAGGCCCTGCAGAGTGGAGGGGGGCAGGAGCGGGGTATG CGGTCTGGGACAGTGCCCACACCCTTAGTGGTGGGGCTGGGGGCTGCGTGTGAGGTGGCA CAGCAAGAGATGGAGTATGACCACAAGCGAATCTCAAAGTTGTCAGAGCGGCTGATACAG AATATAATGAAGAGCCTTCCAGATGTGGTGATGAATGGGGACCCTAAGCACCATTATCCC GGCTGTATCAACCTCTCCTTTGCATATGTGGAAGGGGAAAGTCTGCTGATGGCACTGAAG GACGTTGCCTTATCCTCAGGGAGTGCCTGCACCTCTGCATCCCTGGAGCCCTCTTATGTG CTTAGAGCAATTGGCACTGATGAGGATTTAGCGCACTCTTCTATCAGGTTTGGAATTGGC CGCTTCACTACAGAGGAGGAAGTGGACTACACAGTGGAGAAATGCATTCAGCATGTGAAG CGTCTTCGAGAAATGAGCCCTCTCTGGGAGATGGTTCAGGATGGCATTGACCTCAAGAGC ATCAAGTGGACCCAACACTAG |
GenBank Gene ID | AF097025 |
GeneCard ID | None |
GenAtlas ID | NFS1 |
HGNC ID | HGNC:15910 |
Chromosome Location | 20 |
Locus | 20q11.22 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
L-Cysteine |
121.154 |
||
L-Alanine |
89.094 |