Adenylate kinase isoenzyme 5

NameAdenylate kinase isoenzyme 5
Synonyms2.7.4.3 AK 5 ATP-AMP transphosphorylase 5
Gene NameAK5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008945|Adenylate kinase isoenzyme 5
MNTNDAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVKELGGCDKVKWDTFV
SQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIHQFSIESDTDLSETAELIE
EYEVFDPTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKW
SLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIVIDGFPRDVAQALSFEDQICTPDLV
VFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDA
DRDEDEVFYDISMAVDNKLFPNKEAAAGSSDLDPSMILDTGEIIDTGSDYEDQGDDQLNV
FGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESE
RSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDP
QLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHK
INAEGTPEDVFLQLCTAIDSIF
Number of residues562
Molecular Weight63332.385
Theoretical pINone
GO Classification
Functions
    ATP binding
adenylate kinase activity
nucleoside diphosphate kinase activity
Processes
    ATP metabolic process
nucleoside diphosphate phosphorylation
nucleoside triphosphate biosynthetic process
pyrimidine ribonucleotide biosynthetic process
ADP biosynthetic process
dADP biosynthetic process
small molecule metabolic process
nucleobase-containing small molecule metabolic process
nucleobase-containing small molecule interconversion
Components
    microtubule organizing center
cytoplasm
cytosol
General FunctionNucleoside diphosphate kinase activity
Specific FunctionNucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ9Y6K8
UniProtKB Entry NameKAD5_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0020840|Adenylate kinase isoenzyme 5 (AK5)
ATGTGTTCTAAGCCCGAAGATCCAGTAGAATACTTGGAAAGTTGTTTACAAAAAGTAAAG
GAACTGGGTGGCTGTGACAAGGTGAAATGGGATACATTTGTAAGCCAGGAAAAGAAGACC
TTACCTCCACTAAATGGAGGACAGTCACGGAGATCCTTTCTAAGAAATGTAATGCCTGAA
AACTCAAACTTTCCATATCGGCGGTATGACCGGCTCCCTCCAATCCATCAATTCTCCATA
GAAAGTGACACGGATCTCTCTGAGACTGCAGAGTTGATTGAGGAGTATGAGGTTTTTGAT
CCTACCAGACCTCGACCAAAAATCATTCTTGTTATAGGTGGTCCAGGAAGTGGAAAGGGT
ACTCAGAGTTTGAAAATTGCAGAACGATATGGATTCCAATACATTTCTGTGGGAGAATTA
TTAAGAAAGAAGATCCACAGTACCAGCAGCAATAGGAAATGGAGTCTTATTGCCAAGATA
ATTACAACTGGAGAATTGGCCCCACAGGAAACAACAATTACAGAGATAAAACAAAAATTG
ATGCAAATACCTGATGAAGAGGGCATTGTTATTGATGGATTTCCAAGAGATGTTGCCCAG
GCTCTATCTTTTGAGGACCAAATCTGTACCCCCGATTTGGTGGTATTCCTGGCTTGTGCT
AATCAGAGACTCAAAGAAAGATTACTGAAGCGTGCAGAACAGCAGGGCCGACCAGACGAC
AATGTAAAAGCTACCCAAAGGAGACTAATGAACTTCAAGCAGAATGCTGCTCCATTGGTT
AAATACTTCCAGGAAAAGGGGCTCATCATGACATTTGATGCCGACCGCGATGAGGATGAG
GTGTTCTATGACATCAGCATGGCAGTTGACAACAAGTTATTTCCAAACAAAGAGGCTGCA
GCAGGTTCAAGTGACCTTGATCCTTCGATGATATTGGACACTGGAGAGATCATTGATACA
GGATCTGATTATGAAGATCAGGGTGATGACCAGTTAAATGTATTTGGAGAGGACACTATG
GGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTCCTGGC
TCTGGCAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCA
ACTGGCGAGCTCCTGCGTGAGGAACTGGCATCAGAATCTGAAAGAAGCAAATTGATCAGA
GACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAAGGAG
GCCATGGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAG
GTGAAGCAAGGGGAAGAGTTCGGACGCAGGATTGGAGACCCACAGTTGGTGATCTGTATG
GACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCTGCCT
GTGGACGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATC
CCCGTGATCGCCTACTACGAGACAAAAACACAGCTACACAAGATAAATGCAGAGGGAACA
CCAGAGGACGTTTTTCTTCAACTCTGCACAGCTATTGACTCTATTTTCTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:365
Chromosome Location1
LocusNone
References
  1. Solaroli N, Panayiotou C, Johansson M, Karlsson A: Identification of two active functional domains of human adenylate kinase 5. FEBS Lett. 2009 Sep 3;583(17):2872-6. doi: 10.1016/j.febslet.2009.07.047. Epub 2009 Aug 3.[19647735 ]
  2. Amiri M, Conserva F, Panayiotou C, Karlsson A, Solaroli N: The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. Int J Biochem Cell Biol. 2013 May;45(5):925-31. doi: 10.1016/j.biocel.2013.02.004. Epub 2013 Feb 14.[23416111 ]
  3. Van Rompay AR, Johansson M, Karlsson A: Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein. Eur J Biochem. 1999 Apr;261(2):509-17.[10215863 ]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]

Related FRC

FRCD ID Name Exact Mass Structure




F03325



2-Oxohexane


100.161