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A carbonate-forming Baeyer-Villiger monooxygenase

来源: 时间:六月 18, 2014, 8:45 a.m.

http://www.nature.com/nchembio/journal/v10/n7/full/nchembio.1527.html?WT.ec_id=NCHEMBIO-201407


Despite the remarkable versatility displayed by flavin-dependent monooxygenases (FMOs) in natural product biosynthesis, one notably missing activity is the oxidative generation of carbonate functional groups. We describe a multifunctional Baeyer-Villiger monooxygenase, CcsB, which catalyzes the formation of an in-line carbonate in the macrocyclic portion of cytochalasin E. This study expands the repertoire of activities of FMOs and provides a possible synthetic strategy for transformation of ketones into carbonates.


http://www.nature.com/nchembio/journal/v10/n7/full/nchembio.1531.html


Biosynthesis: A carbonate architect emerges

  • Carbonates are known to exist in natural products, but their biosynthesis has not been linked to any enzymes. An unusual fungal Baeyer-Villiger monooxygenase CcsB is now revealed to catalyze an in-line carbonate formation via a two-step mechanism of oxygen atom insertions.



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