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Natural products: Sponge symbionts play defense

来源: 时间:七月 21, 2014, 9:55 a.m.

http://www.nature.com/nchembio/journal/v10/n8/full/nchembio.1588.html?WT.ec_id=NCHEMBIO-201408


The gene cluster that produces the sponge-derived cytotoxin calyculin A has been located in an uncultivated bacterial symbiont. Biochemical analyses reveal a pyrophosphorylated protoxin as the true biosynthetic product and suggest that calyculins result from activated chemical defense.


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