SynBio-NatureSpecial

来源：qnhu 时间：May 17, 2014, 2:35 p.m.

http://www.nature.com/news/specials/synbio-1.15137

BEYOND DIVISIONS

Since its debut in 2000, synthetic biology has seen considerable growth and now constitutes a vibrant research discipline that aims to apply engineering principles in the design and construction of complex biological systems. This Nature special charts the progress of the multidisciplinary field through reports, reviews and commentaries from Nature, Nature Methods and Nature Reviews Microbiology. Together, these explore the field’s potential and its challenges in developing clear goals, standards of practice and pathways to commercialization. A selection of material from the archives of Nature Publishing Group is also available.

• Editorial

• News and News Features

• Commentary

• News & Views

• Perspectives

• Reviews

• Research Articles

• Archive

• Archive of earlier articles

EDITORIAL

• Tribal gathering

  

  Before they can construct a cell, researchers in synthetic biology must first build bridges between disciplines.

  Nature (07 May 2014)

• Milestones in synthetic (micro)biology

  

  Synthetic biology is a vibrant and vigorous scientific discipline that has its roots firmly grounded in microbiology.

  Nature Reviews Microbiology (16 April 2014)

• Synthetic Biology: Back to the Basics

  

  Realizing the ambitious goals of synthetic biology requires continued efforts in characterizing the foundations.

  Nature Methods (29 April 2014)

NEWS AND NEWS FEATURES

• Cultural divide

  

  Synthetic biology is facing a tug of war over whether to patent its discoveries or embrace open-source innovation.

  Nature (07 May 2014)

• First life with 'alien' DNA

  

  An engineered bacterium is able to copy DNA that contains unnatural genetic letters.

  Nature (07 May 2014)

COMMENTARY

• World View: Time to settle the synthetic controversy

  

  If synthetic biology is to thrive, the world needs to decide now how the field should be regulated and supported, says Volker ter Meulen.

  Nature (07 May 2014)

• How best to build a cell

  

  Experts weigh in on the biggest obstacles in synthetic biology — from names to knowledge gaps — and what it will take to overcome them.

  Nature (07 May 2014)

• A synthetic approach to abiogenesis

  

  Attwater & Holliger

  Nature Methods (29 April 2014)

NEWS & VIEWS

• Engineering explored

  

  Two views on the best way to engineer biological components so that they reliably generate organisms with desired traits.

  Nature (07 May 2014)

• Construction of a yeast chromosome

  

  An entire yeast chromosome has been converted to a synthetic sequence in a stepwise manner —  a stage towards the creation of complex synthetic organisms.

  Nature (07 May 2014)

• New letters for life’s alphabet

  

  The construction of an organism that stably propagates an unnatural DNA base pair redefines this fundamental feature of life.

  Nature (07 May 2014)

PERSPECTIVES

• A brief history of synthetic biology

  Cameron, Bashor & Collins

  Nature Reviews Microbiology (16 April 2014)

• Programming biological operating systems: genome design, assembly and activation

  Gibson

  Nature Methods (29 April 2014)

REVIEWS

• A versatile framework for microbial engineering using synthetic noncoding RNAs

  Qi & Arkin

  Nature Reviews Microbiology (16 April 2014)

• Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development

  Paddon & Keasling

  Nature Reviews Microbiology (16 April 2014)

• Biotechnological domestication of pseudomonads using synthetic biology

  Nikel, Martínez-García & de Lorenzo

  Nature Reviews Microbiology (16 April 2014)

• Large-scale de novo DNA synthesis: technologies and applications

  Kosuri & Church

  Nature Methods (29 April 2014)

• Principles of genetic circuit design

  Brophy & Voigt

  Nature Methods (29 April 2014)

RESEARCH ARTICLES

• A semi-synthetic organism with an expanded genetic alphabet

  Malyshev et al.

  Nature (07 May 2014)

• Interactive assembly algorithms for molecular cloning

  Appleton et al.

  Nature Methods (28 April 2014)

• Engineering synergy in biotechnology

  Nielsen et al.

  Nature Chemical Biology (17 April 2014)

• Rapid and tunable post-translational coupling of genetic circuits

  Prindle et al.

  Nature (09 April 2014)

• An auto-inducible mechanism for ionic liquid resistance in microbial biofuel production

  Ruegg et al.

  Nature Communications (09 April 2014)

ARCHIVE

• Research and review articles

  See a comprehensive list of synthetic biology articles.

  Nature Publishing Group (07 May 2014)

ARCHIVE: RESEARCH ARTICLES

• Bioretrosynthetic construction of a didanosine biosynthetic pathway

  Birmingham et al.

  Nature Chemical Biology, (23 March 2014)

• Synthesis and patterning of tunable multiscale materials with engineered cells

  Chen et al.

  Nature Materials, (23 March 2014)

• Characterizing bacterial gene circuit dynamics with optically programmed gene expression signals

  Olson et al.

  Nature Methods, (9 March 2014)

• Designable DNA-binding domains enable construction of logic circuits in mammalian cells

  Gaber et al.

  Nature Chemical Biology 10, 203–20 (12 January 2014)

• Efficient ethanol production from brown macroalgae sugars by a synthetic yeast platform

  Enquist-Newman et al.

  Nature 505, 239–243 (09 January 2014)

• Genomic mining of prokaryotic repressors for orthogonal logic gates

  Stanton et al.

  Nature Chemical Biology 10, 99–105 (8 December 2013)

• A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice

  Rössger et al.

  Nature Communications 4, 2825 (26 November 2013)

• Directed evolution of genetic parts and circuits by compartmentalized partnered replication

  Ellefson et al.

  Nature Biotechnology 32, 97–101 (3 November 2013)

• Engineering dynamic pathway regulation using stress-response promoters

  Dahl et al.

  Nature Biotechnology 31, 1039–1046 (20 October 2013)

• Programming adaptive control to evolve increased metabolite production

  Chou et al.

  Nature Communications 4, 2595 (17 October 2013)

• Programmable chemical controllers made from DNA

  Chen et al.

  Nature Nanotechnology 8, 755–762 (29 September 2013)

• RNA-guided gene activation by CRISPR-Cas9-based transcription factors

  Perez-Pinera et al.

  Nature Methods 10, 973–976 (25 July 2013)

• Molecular crowding shapes gene expression in synthetic cellular nanosystems

  Tan et al.

  Nature Nanotechnology 8, 602–608 (14 July 2013)

• Characterization of 582 natural and synthetic terminators and quantification of their design constraints

  Chen et al.

  Nature Methods 10, 659–664 (2 June 2013)

• Synthetic analog computation in living cells

  Daniel et al.

  Nature 497, 619–623 (30 May 2013)

• High-level semi-synthetic production of the potent antimalarial artemisinin.

  Paddon et al.

  Nature 496, 528–532 (25 April 2013)

• Direct transfer of whole genomes from bacteria to yeast

  Karas et al.

  Nature Methods 10, 410–412 (31 March 2013)

• Precise and reliable gene expression via standard transcription and translation initiation elements

  Mutalik et al.

  Nature Methods 10, 354–360 (10 March 2013)

• Quantitative estimation of activity and quality for collections of functional genetic elements

  Mutalik et al.

  Nature Methods 10, 347–353 (10 March 2013)

• Synthetic circuits integrating logic and memory in living cells

  Siuti et al.

  Nature Biotechnology 31, 448–452 (10 February 2013)

• Transferring a synthetic gene circuit from yeast to mammalian cells

  Nevozhay et al.

  Nature Communications 4, 1451 (5 February 2013)

• Synthetic RNA devices to expedite the evolution of metabolite-producing microbes

  Yang et al.

  Nature Communications 4, 1413 (29 January 2013)

• Modular optimization of multi-gene pathways for fatty acids production in E. coli.

  Xu et al.

  Nature Communications 4, 1409 (29 Januray 2013)

• Towards practical, high-capacity, low-maintenance information storage in synthesized DNA

  Goldman et al.

  Nature 494, 77–80 (23 January 2013)

• Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs

  Na et al.

  Nature Biotechnology 31, 170–174 (20 January 2013)

ARCHIVE: NEWS & REVIEWS

• Realizing the potential of synthetic biology

  Church et al.

  Nature Reviews Molecular Cell Biology 15, 289–294 (12 March 2014)

• Synthetic biology in mammalian cells: next generation research tools and therapeutics

  Lienert et al.

  Nature Reviews Molecular Cell Biology 15, 95–107 (17 January 2014)

• Advanced genetic tools for plant biotechnology

  Liu et al.

  Nature Reviews Genetics 14, 781–793 (09 October 2013)

• Upgrading protein synthesis for synthetic biology

  O'Donoghue et al.

  Nature Chemical Biology 9, 594–598 (17 September 2013)

• Building a better stop sign: understanding the signals that terminate transcription

  Mooney et al.

  Nature Methods 10, 618–619 (27 June 2013)

• Endowing cells with logic and memory

  Maranhao et al.

  Nature Biotechnology 31, 413–415 (08 May 2013)

• RNA guides genome engineering

  Mussolino et al.

  Nature Biotechnology 31, 208–209 (07 March 2013)

• Biotechnology: Rewriting a genome

  Charpentier et al.

  Nature 495, 50–51 (06 March 2013)

• Microbial engineering for the production of advanced biofuels

  Peralta-Yahya et al.

  Nature 488, 320–328 (15 August 2012)

• Foundations for the design and implementation of synthetic genetic circuits

  Slusarczyk et al.

  Nature Reviews Genetics 13, 406–420 (18 May 2012)

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