Diisoundecyl Phthalate (Predicted)
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Basic Info
FADB-China ID | P1250 |
Molecular Name | Diisoundecyl Phthalate |
Basis for prediction | DEHP |
Similarity (based on Tanimoto coefficient and ECFP6 fingerprint) | 0.6273 |
Similarity (based on Tanimoto coefficient and Daylight fingerprint) | 0.9463 |
Similarity (based on MCS) | 0.7027 |
2D Structure | |
SMILES | CCCCCCCCCCCCOC(=O)c1ccccc1C(=O)OCC(CCC)C(CC)CCC |
CFM-ID 3.0 (Copy SMILES to the website's input box) | URL Link |
Update Date | Jul 30, 2019 14:16 |
ADMET
Model | Result | Probability |
---|---|---|
Absorption | ||
Blood-Brain Barrier | BBB+ | 0.9422 |
Human Intestinal Absorption | HIA+ | 0.9751 |
Caco-2 Permeability | Caco2+ | 0.7014 |
P-glycoprotein Substrate | Substrate | 0.5000 |
P-glycoprotein Inhibitor | Non-inhibitor | 0.6918 |
Non-inhibitor | 0.7542 | |
Renal Organic Cation Transporter | Non-inhibitor | 0.8464 |
Distribution | ||
Subcellular localization | Mitochondria | 0.8745 |
Metabolism | ||
CYP450 2C9 Substrate | Non-substrate | 0.8547 |
CYP450 2D6 Substrate | Non-substrate | 0.8752 |
CYP450 3A4 Substrate | Non-substrate | 0.5541 |
CYP450 1A2 Inhibitor | Non-inhibitor | 0.6798 |
CYP450 2C9 Inhibitor | Non-inhibitor | 0.8072 |
CYP450 2D6 Inhibitor | Non-inhibitor | 0.8484 |
CYP450 2C19 Inhibitor | Non-inhibitor | 0.6324 |
CYP450 3A4 Inhibitor | Non-inhibitor | 0.7759 |
CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | 0.6898 |
Excretion | ||
Toxicity | ||
Human Ether-a-go-go-Related Gene Inhibition | Weak inhibitor | 0.8904 |
Non-inhibitor | 0.7354 | |
AMES Toxicity | Non AMES toxic | 0.9364 |
Carcinogens | Non-carcinogens | 0.7249 |
Fish Toxicity | High FHMT | 0.9924 |
Tetrahymena Pyriformis Toxicity | High TPT | 0.9999 |
Honey Bee Toxicity | High HBT | 0.5633 |
Biodegradation | Ready biodegradable | 0.6079 |
Acute Oral Toxicity | IV | 0.7807 |
Carcinogenicity (Three-class) | Warning | 0.5422 |
ADMET -- Regression
Model | Value | Unit |
---|---|---|
Aqueous solubility | -6.2835 | LogS |
Caco-2 Permeability | 0.9862 | LogPapp, cm/s |
Rat Acute Toxicity | 1.0755 | LD50, mol/kg |
Fish Toxicity | 0.1349 | pLC50, mg/L |
Tetrahymena Pyriformis Toxicity | 2.0984 | pIGC50, ug/L |
References
Title | Data Sources |
---|---|
Source | HPV EPA Chemicals, National Health Commission of the People's Republic of China, T3DB, OECD HPV Chemicals |
PubChem Link | URL Link |