Propionic acid (Predicted)
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Basic Info
FADB-China ID | P1372 |
Molecular Name | Propionic acid |
Basis for prediction | Calcium propionate |
Similarity (based on Tanimoto coefficient and ECFP6 fingerprint) | 0.4000 |
Similarity (based on Tanimoto coefficient and Daylight fingerprint) | 1.0000 |
Similarity (based on MCS) | 0.4545 |
2D Structure | |
SMILES | CCC(=O)O |
CFM-ID 3.0 (Copy SMILES to the website's input box) | URL Link |
Update Date | Jul 30, 2019 14:16 |
ADMET
Model | Result | Probability |
---|---|---|
Absorption | ||
Blood-Brain Barrier | BBB+ | 0.9410 |
Human Intestinal Absorption | HIA+ | 0.9893 |
Caco-2 Permeability | Caco2+ | 0.6324 |
P-glycoprotein Substrate | Non-substrate | 0.7959 |
P-glycoprotein Inhibitor | Non-inhibitor | 0.9671 |
Non-inhibitor | 0.9909 | |
Renal Organic Cation Transporter | Non-inhibitor | 0.9624 |
Distribution | ||
Subcellular localization | Mitochondria | 0.5849 |
Metabolism | ||
CYP450 2C9 Substrate | Non-substrate | 0.7880 |
CYP450 2D6 Substrate | Non-substrate | 0.9394 |
CYP450 3A4 Substrate | Non-substrate | 0.8006 |
CYP450 1A2 Inhibitor | Non-inhibitor | 0.8922 |
CYP450 2C9 Inhibitor | Non-inhibitor | 0.9639 |
CYP450 2D6 Inhibitor | Non-inhibitor | 0.9667 |
CYP450 2C19 Inhibitor | Non-inhibitor | 0.9794 |
CYP450 3A4 Inhibitor | Non-inhibitor | 0.9763 |
CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | 0.9876 |
Excretion | ||
Toxicity | ||
Human Ether-a-go-go-Related Gene Inhibition | Weak inhibitor | 0.9681 |
Non-inhibitor | 0.9778 | |
AMES Toxicity | Non AMES toxic | 0.9401 |
Carcinogens | Carcinogens | 0.6548 |
Fish Toxicity | Low FHMT | 0.5937 |
Tetrahymena Pyriformis Toxicity | Low TPT | 0.8365 |
Honey Bee Toxicity | High HBT | 0.7513 |
Biodegradation | Ready biodegradable | 0.9079 |
Acute Oral Toxicity | III | 0.9124 |
Carcinogenicity (Three-class) | Non-required | 0.7073 |
ADMET -- Regression
Model | Value | Unit |
---|---|---|
Aqueous solubility | 0.6067 | LogS |
Caco-2 Permeability | 1.1352 | LogPapp, cm/s |
Rat Acute Toxicity | 1.4864 | LD50, mol/kg |
Fish Toxicity | 3.5551 | pLC50, mg/L |
Tetrahymena Pyriformis Toxicity | -0.6348 | pIGC50, ug/L |
References
Title | Data Sources |
---|---|
Source | ToxCast & Tox21 Chemicals, OpenFoodTox, DrugBank, HPV EPA Chemicals, ToxinDB, T3DB, OECD HPV Chemicals |
PubChem Link | URL Link |