1,3,5-Triazine, hexahydro-1,3,5-trimethyl- (Predicted)
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Basic Info
FADB-China ID | P1418 |
Molecular Name | 1,3,5-Triazine, hexahydro-1,3,5-trimethyl- |
Basis for prediction | Methenamine |
Similarity (based on Tanimoto coefficient and ECFP6 fingerprint) | 0.2769 |
Similarity (based on Tanimoto coefficient and Daylight fingerprint) | 0.8750 |
Similarity (based on MCS) | 0.4615 |
2D Structure | |
SMILES | CN1CN(C)CN(C)C1 |
CFM-ID 3.0 (Copy SMILES to the website's input box) | URL Link |
Update Date | Jul 30, 2019 14:16 |
ADMET
Model | Result | Probability |
---|---|---|
Absorption | ||
Blood-Brain Barrier | BBB+ | 0.9689 |
Human Intestinal Absorption | HIA+ | 0.8612 |
Caco-2 Permeability | Caco2+ | 0.6642 |
P-glycoprotein Substrate | Non-substrate | 0.6010 |
P-glycoprotein Inhibitor | Non-inhibitor | 0.9567 |
Non-inhibitor | 0.9539 | |
Renal Organic Cation Transporter | Non-inhibitor | 0.5879 |
Distribution | ||
Subcellular localization | Lysosome | 0.5516 |
Metabolism | ||
CYP450 2C9 Substrate | Non-substrate | 0.9006 |
CYP450 2D6 Substrate | Non-substrate | 0.6679 |
CYP450 3A4 Substrate | Non-substrate | 0.6466 |
CYP450 1A2 Inhibitor | Non-inhibitor | 0.5741 |
CYP450 2C9 Inhibitor | Non-inhibitor | 0.8380 |
CYP450 2D6 Inhibitor | Non-inhibitor | 0.7987 |
CYP450 2C19 Inhibitor | Non-inhibitor | 0.8692 |
CYP450 3A4 Inhibitor | Non-inhibitor | 0.9518 |
CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | 0.8994 |
Excretion | ||
Toxicity | ||
Human Ether-a-go-go-Related Gene Inhibition | Weak inhibitor | 0.8149 |
Non-inhibitor | 0.8211 | |
AMES Toxicity | AMES toxic | 0.5392 |
Carcinogens | Non-carcinogens | 0.8621 |
Fish Toxicity | Low FHMT | 0.9749 |
Tetrahymena Pyriformis Toxicity | Low TPT | 0.8517 |
Honey Bee Toxicity | Low HBT | 0.6972 |
Biodegradation | Ready biodegradable | 0.7445 |
Acute Oral Toxicity | II | 0.6357 |
Carcinogenicity (Three-class) | Non-required | 0.5757 |
ADMET -- Regression
Model | Value | Unit |
---|---|---|
Aqueous solubility | -0.8356 | LogS |
Caco-2 Permeability | 1.5565 | LogPapp, cm/s |
Rat Acute Toxicity | 2.8052 | LD50, mol/kg |
Fish Toxicity | 3.5865 | pLC50, mg/L |
Tetrahymena Pyriformis Toxicity | -0.1276 | pIGC50, ug/L |
References
Title | Data Sources |
---|---|
Source | HPV EPA Chemicals, ToxCast & Tox21 Chemicals |
PubChem Link | URL Link |