Phthalic acid, bis (methylcyclohexyl) ester (Predicted)
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Basic Info
FADB-China ID | P1441 |
Molecular Name | Phthalic acid, bis (methylcyclohexyl) ester |
Basis for prediction | DCHP |
Similarity (based on Tanimoto coefficient and ECFP6 fingerprint) | 0.5556 |
Similarity (based on Tanimoto coefficient and Daylight fingerprint) | 0.9233 |
Similarity (based on MCS) | 0.9231 |
2D Structure | |
SMILES | CC1(OC(=O)c2ccccc2C(=O)OC2(C)CCCCC2)CCCCC1 |
CFM-ID 3.0 (Copy SMILES to the website's input box) | URL Link |
Update Date | Jul 30, 2019 14:16 |
ADMET
Model | Result | Probability |
---|---|---|
Absorption | ||
Blood-Brain Barrier | BBB+ | 0.9652 |
Human Intestinal Absorption | HIA+ | 0.9807 |
Caco-2 Permeability | Caco2+ | 0.7301 |
P-glycoprotein Substrate | Substrate | 0.5676 |
P-glycoprotein Inhibitor | Inhibitor | 0.5484 |
Non-inhibitor | 0.7155 | |
Renal Organic Cation Transporter | Non-inhibitor | 0.8048 |
Distribution | ||
Subcellular localization | Mitochondria | 0.9371 |
Metabolism | ||
CYP450 2C9 Substrate | Non-substrate | 0.7837 |
CYP450 2D6 Substrate | Non-substrate | 0.8985 |
CYP450 3A4 Substrate | Substrate | 0.6426 |
CYP450 1A2 Inhibitor | Non-inhibitor | 0.8499 |
CYP450 2C9 Inhibitor | Non-inhibitor | 0.6419 |
CYP450 2D6 Inhibitor | Non-inhibitor | 0.9193 |
CYP450 2C19 Inhibitor | Non-inhibitor | 0.8132 |
CYP450 3A4 Inhibitor | Non-inhibitor | 0.7807 |
CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | 0.9204 |
Excretion | ||
Toxicity | ||
Human Ether-a-go-go-Related Gene Inhibition | Weak inhibitor | 0.9507 |
Non-inhibitor | 0.6514 | |
AMES Toxicity | Non AMES toxic | 0.9614 |
Carcinogens | Non-carcinogens | 0.8711 |
Fish Toxicity | High FHMT | 0.9887 |
Tetrahymena Pyriformis Toxicity | High TPT | 0.9760 |
Honey Bee Toxicity | High HBT | 0.6484 |
Biodegradation | Not ready biodegradable | 0.7952 |
Acute Oral Toxicity | III | 0.6112 |
Carcinogenicity (Three-class) | Non-required | 0.6225 |
ADMET -- Regression
Model | Value | Unit |
---|---|---|
Aqueous solubility | -5.0537 | LogS |
Caco-2 Permeability | 0.9806 | LogPapp, cm/s |
Rat Acute Toxicity | 1.3176 | LD50, mol/kg |
Fish Toxicity | -0.3036 | pLC50, mg/L |
Tetrahymena Pyriformis Toxicity | 1.7147 | pIGC50, ug/L |
References
Title | Data Sources |
---|---|
Source | National Health Commission of the People's Republic of China, OpenFoodTox |
PubChem Link | URL Link |