Benzoic Acid (Predicted)
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Basic Info
FADB-China ID | P1501 |
Molecular Name | Benzoic Acid |
Basis for prediction | Potassium benzoate |
Similarity (based on Tanimoto coefficient and ECFP6 fingerprint) | 0.7586 |
Similarity (based on Tanimoto coefficient and Daylight fingerprint) | 1.0000 |
Similarity (based on MCS) | 0.9000 |
2D Structure | |
SMILES | O=C(O)c1ccccc1 |
CFM-ID 3.0 (Copy SMILES to the website's input box) | URL Link |
Update Date | Jul 30, 2019 14:16 |
ADMET
Model | Result | Probability |
---|---|---|
Absorption | ||
Blood-Brain Barrier | BBB+ | 0.9557 |
Human Intestinal Absorption | HIA+ | 0.9886 |
Caco-2 Permeability | Caco2+ | 0.9187 |
P-glycoprotein Substrate | Non-substrate | 0.8494 |
P-glycoprotein Inhibitor | Non-inhibitor | 0.9914 |
Non-inhibitor | 0.9941 | |
Renal Organic Cation Transporter | Non-inhibitor | 0.9136 |
Distribution | ||
Subcellular localization | Mitochondria | 0.6419 |
Metabolism | ||
CYP450 2C9 Substrate | Non-substrate | 0.8003 |
CYP450 2D6 Substrate | Non-substrate | 0.9672 |
CYP450 3A4 Substrate | Non-substrate | 0.8374 |
CYP450 1A2 Inhibitor | Non-inhibitor | 0.8532 |
CYP450 2C9 Inhibitor | Non-inhibitor | 0.9861 |
CYP450 2D6 Inhibitor | Non-inhibitor | 0.9570 |
CYP450 2C19 Inhibitor | Non-inhibitor | 0.9878 |
CYP450 3A4 Inhibitor | Non-inhibitor | 0.9822 |
CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | 0.9863 |
Excretion | ||
Toxicity | ||
Human Ether-a-go-go-Related Gene Inhibition | Weak inhibitor | 0.9708 |
Non-inhibitor | 0.9882 | |
AMES Toxicity | Non AMES toxic | 0.9923 |
Carcinogens | Non-carcinogens | 0.6024 |
Fish Toxicity | High FHMT | 0.7212 |
Tetrahymena Pyriformis Toxicity | High TPT | 0.8716 |
Honey Bee Toxicity | High HBT | 0.7230 |
Biodegradation | Ready biodegradable | 0.8983 |
Acute Oral Toxicity | III | 0.8104 |
Carcinogenicity (Three-class) | Non-required | 0.7497 |
ADMET -- Regression
Model | Value | Unit |
---|---|---|
Aqueous solubility | -1.5012 | LogS |
Caco-2 Permeability | 1.8481 | LogPapp, cm/s |
Rat Acute Toxicity | 1.7896 | LD50, mol/kg |
Fish Toxicity | 2.5602 | pLC50, mg/L |
Tetrahymena Pyriformis Toxicity | -0.4980 | pIGC50, ug/L |
References
Title | Data Sources |
---|---|
Source | ToxCast & Tox21 Chemicals, OpenFoodTox, DrugBank, HPV EPA Chemicals, ToxinDB, T3DB, OECD HPV Chemicals |
PubChem Link | URL Link |