Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxooctadecyl)-.omega.-[(1-oxooctadecyl)oxy]- (Predicted)
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Basic Info
FADB-China ID | P1723 |
Molecular Name | Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxooctadecyl)-.omega.-[(1-oxooctadecyl)oxy]- |
Basis for prediction | Adipic acid |
Similarity (based on Tanimoto coefficient and ECFP6 fingerprint) | 0.3364 |
Similarity (based on Tanimoto coefficient and Daylight fingerprint) | 0.8571 |
Similarity (based on MCS) | 0.3200 |
2D Structure | |
SMILES | CCCCCCCCCCCCCCCCC(=O)O.OCCO |
CFM-ID 3.0 (Copy SMILES to the website's input box) | URL Link |
Update Date | Jul 30, 2019 14:16 |
ADMET
Model | Result | Probability |
---|---|---|
Absorption | ||
Blood-Brain Barrier | BBB- | 0.5250 |
Human Intestinal Absorption | HIA+ | 0.8669 |
Caco-2 Permeability | Caco2- | 0.5639 |
P-glycoprotein Substrate | Substrate | 0.5906 |
P-glycoprotein Inhibitor | Non-inhibitor | 0.9674 |
Non-inhibitor | 0.9611 | |
Renal Organic Cation Transporter | Non-inhibitor | 0.9301 |
Distribution | ||
Subcellular localization | Mitochondria | 0.6973 |
Metabolism | ||
CYP450 2C9 Substrate | Non-substrate | 0.8423 |
CYP450 2D6 Substrate | Non-substrate | 0.8454 |
CYP450 3A4 Substrate | Non-substrate | 0.6907 |
CYP450 1A2 Inhibitor | Non-inhibitor | 0.6682 |
CYP450 2C9 Inhibitor | Non-inhibitor | 0.8929 |
CYP450 2D6 Inhibitor | Non-inhibitor | 0.9380 |
CYP450 2C19 Inhibitor | Non-inhibitor | 0.9172 |
CYP450 3A4 Inhibitor | Non-inhibitor | 0.9024 |
CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | 0.9803 |
Excretion | ||
Toxicity | ||
Human Ether-a-go-go-Related Gene Inhibition | Weak inhibitor | 0.9760 |
Non-inhibitor | 0.7475 | |
AMES Toxicity | Non AMES toxic | 0.9747 |
Carcinogens | Non-carcinogens | 0.8305 |
Fish Toxicity | High FHMT | 0.9395 |
Tetrahymena Pyriformis Toxicity | High TPT | 0.9927 |
Honey Bee Toxicity | High HBT | 0.5489 |
Biodegradation | Ready biodegradable | 0.9140 |
Acute Oral Toxicity | IV | 0.7335 |
Carcinogenicity (Three-class) | Non-required | 0.7448 |
ADMET -- Regression
Model | Value | Unit |
---|---|---|
Aqueous solubility | -2.5439 | LogS |
Caco-2 Permeability | 0.1887 | LogPapp, cm/s |
Rat Acute Toxicity | 1.0268 | LD50, mol/kg |
Fish Toxicity | 2.9971 | pLC50, mg/L |
Tetrahymena Pyriformis Toxicity | 0.8558 | pIGC50, ug/L |
References
Title | Data Sources |
---|---|
Source | HPV EPA Chemicals |
PubChem Link | URL Link |