N-Octanoyl-B-D-Fructofuranosyl-a-D-Glucopyranoside,Sucrose Monocaproylate (Predicted)
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Basic Info
FADB-China ID | P2249 |
Molecular Name | N-Octanoyl-B-D-Fructofuranosyl-a-D-Glucopyranoside,Sucrose Monocaproylate |
Basis for prediction | Sucrose |
Similarity (based on Tanimoto coefficient and ECFP6 fingerprint) | 0.7263 |
Similarity (based on Tanimoto coefficient and Daylight fingerprint) | 0.8716 |
Similarity (based on MCS) | 0.7188 |
2D Structure | |
SMILES | CCCCCCCC(=O)OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O |
CFM-ID 3.0 (Copy SMILES to the website's input box) | URL Link |
Update Date | Jul 30, 2019 14:16 |
ADMET
Model | Result | Probability |
---|---|---|
Absorption | ||
Blood-Brain Barrier | BBB- | 0.5565 |
Human Intestinal Absorption | HIA+ | 0.5258 |
Caco-2 Permeability | Caco2- | 0.7939 |
P-glycoprotein Substrate | Substrate | 0.6904 |
P-glycoprotein Inhibitor | Non-inhibitor | 0.7482 |
Non-inhibitor | 0.8287 | |
Renal Organic Cation Transporter | Non-inhibitor | 0.8207 |
Distribution | ||
Subcellular localization | Mitochondria | 0.8250 |
Metabolism | ||
CYP450 2C9 Substrate | Non-substrate | 0.8436 |
CYP450 2D6 Substrate | Non-substrate | 0.8234 |
CYP450 3A4 Substrate | Non-substrate | 0.5134 |
CYP450 1A2 Inhibitor | Non-inhibitor | 0.8744 |
CYP450 2C9 Inhibitor | Non-inhibitor | 0.8780 |
CYP450 2D6 Inhibitor | Non-inhibitor | 0.9316 |
CYP450 2C19 Inhibitor | Non-inhibitor | 0.8365 |
CYP450 3A4 Inhibitor | Non-inhibitor | 0.9001 |
CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | 0.9268 |
Excretion | ||
Toxicity | ||
Human Ether-a-go-go-Related Gene Inhibition | Weak inhibitor | 0.9614 |
Non-inhibitor | 0.5271 | |
AMES Toxicity | Non AMES toxic | 0.9008 |
Carcinogens | Non-carcinogens | 0.9581 |
Fish Toxicity | High FHMT | 0.7876 |
Tetrahymena Pyriformis Toxicity | High TPT | 0.9935 |
Honey Bee Toxicity | High HBT | 0.6667 |
Biodegradation | Not ready biodegradable | 0.6308 |
Acute Oral Toxicity | III | 0.5383 |
Carcinogenicity (Three-class) | Non-required | 0.6874 |
ADMET -- Regression
Model | Value | Unit |
---|---|---|
Aqueous solubility | -1.3726 | LogS |
Caco-2 Permeability | -0.3534 | LogPapp, cm/s |
Rat Acute Toxicity | 2.0279 | LD50, mol/kg |
Fish Toxicity | 2.2305 | pLC50, mg/L |
Tetrahymena Pyriformis Toxicity | 0.6797 | pIGC50, ug/L |
References
Title | Data Sources |
---|---|
Source | DrugBank |
PubChem Link | URL Link |