Polyethylene glycol 3000 (Predicted)
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Basic Info
FADB-China ID | P0985 |
Molecular Name | Polyethylene glycol 3000 |
Basis for prediction | Alcohol |
Similarity (based on Tanimoto coefficient and ECFP6 fingerprint) | 0.4000 |
Similarity (based on Tanimoto coefficient and Daylight fingerprint) | 0.8571 |
Similarity (based on MCS) | 0.7500 |
2D Structure | |
SMILES | OCCO |
CFM-ID 3.0 (Copy SMILES to the website's input box) | URL Link |
Update Date | Jul 30, 2019 14:16 |
ADMET
Model | Result | Probability |
---|---|---|
Absorption | ||
Blood-Brain Barrier | BBB+ | 0.6683 |
Human Intestinal Absorption | HIA+ | 0.8619 |
Caco-2 Permeability | Caco2- | 0.5510 |
P-glycoprotein Substrate | Non-substrate | 0.7466 |
P-glycoprotein Inhibitor | Non-inhibitor | 0.9503 |
Non-inhibitor | 0.9538 | |
Renal Organic Cation Transporter | Non-inhibitor | 0.9099 |
Distribution | ||
Subcellular localization | Mitochondria | 0.4519 |
Metabolism | ||
CYP450 2C9 Substrate | Non-substrate | 0.8623 |
CYP450 2D6 Substrate | Non-substrate | 0.8714 |
CYP450 3A4 Substrate | Non-substrate | 0.7994 |
CYP450 1A2 Inhibitor | Non-inhibitor | 0.8432 |
CYP450 2C9 Inhibitor | Non-inhibitor | 0.9267 |
CYP450 2D6 Inhibitor | Non-inhibitor | 0.9729 |
CYP450 2C19 Inhibitor | Non-inhibitor | 0.9355 |
CYP450 3A4 Inhibitor | Non-inhibitor | 0.9657 |
CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | 0.9634 |
Excretion | ||
Toxicity | ||
Human Ether-a-go-go-Related Gene Inhibition | Weak inhibitor | 0.9135 |
Non-inhibitor | 0.9176 | |
AMES Toxicity | Non AMES toxic | 0.9133 |
Carcinogens | Non-carcinogens | 0.6055 |
Fish Toxicity | Low FHMT | 0.9137 |
Tetrahymena Pyriformis Toxicity | Low TPT | 0.9953 |
Honey Bee Toxicity | High HBT | 0.6386 |
Biodegradation | Ready biodegradable | 0.8208 |
Acute Oral Toxicity | III | 0.7757 |
Carcinogenicity (Three-class) | Non-required | 0.6447 |
ADMET -- Regression
Model | Value | Unit |
---|---|---|
Aqueous solubility | 1.2264 | LogS |
Caco-2 Permeability | 0.7862 | LogPapp, cm/s |
Rat Acute Toxicity | 1.1526 | LD50, mol/kg |
Fish Toxicity | 3.3807 | pLC50, mg/L |
Tetrahymena Pyriformis Toxicity | -2.4177 | pIGC50, ug/L |
References
Title | Data Sources |
---|---|
Source | , OpenFoodTox, ToxCast & Tox21 Chemicals, FRCD, HPV EPA Chemicals, T3DB, OECD HPV Chemicals |
PubChem Link | URL Link |