ACETALDEHYDE
Relevant Data
Food Additives Approved by WHO:
Flavouring Substances Approved by European Union:
General Information
Mainterm | ACETALDEHYDE |
Doc Type | ASP |
CAS Reg.No.(or other ID) | 75-07-0 |
Regnum |
177.2410 182.60 |
From www.fda.gov
Computed Descriptors
Download SDF2D Structure | |
CID | 177 |
IUPAC Name | acetaldehyde |
InChI | InChI=1S/C2H4O/c1-2-3/h2H,1H3 |
InChI Key | IKHGUXGNUITLKF-UHFFFAOYSA-N |
Canonical SMILES | CC=O |
Molecular Formula | C2H4O |
Wikipedia | acetaldehyde |
From Pubchem
Computed Properties
Property Name | Property Value |
---|---|
Molecular Weight | 44.053 |
Hydrogen Bond Donor Count | 0 |
Hydrogen Bond Acceptor Count | 1 |
Rotatable Bond Count | 0 |
Complexity | 10.3 |
CACTVS Substructure Key Fingerprint | A A A D c Y B A I A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A G g A A A A A A A A C g g A I C A A A A A A A I A A g Q g A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A = = |
Topological Polar Surface Area | 17.1 |
Monoisotopic Mass | 44.026 |
Exact Mass | 44.026 |
XLogP3 | None |
XLogP3-AA | -0.3 |
Compound Is Canonicalized | True |
Formal Charge | 0 |
Heavy Atom Count | 3 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Isotope Atom Count | 0 |
Covalently-Bonded Unit Count | 1 |
From Pubchem
Food Additives Biosynthesis/Degradation
ADMET Predicted Profile --- Classification
Model | Result | Probability |
---|---|---|
Absorption | ||
Blood-Brain Barrier | BBB+ | 0.9833 |
Human Intestinal Absorption | HIA+ | 0.9942 |
Caco-2 Permeability | Caco2+ | 0.7557 |
P-glycoprotein Substrate | Non-substrate | 0.8268 |
P-glycoprotein Inhibitor | Non-inhibitor | 0.9712 |
Non-inhibitor | 0.9820 | |
Renal Organic Cation Transporter | Non-inhibitor | 0.9246 |
Distribution | ||
Subcellular localization | Mitochondria | 0.4845 |
Metabolism | ||
CYP450 2C9 Substrate | Non-substrate | 0.7858 |
CYP450 2D6 Substrate | Non-substrate | 0.9309 |
CYP450 3A4 Substrate | Non-substrate | 0.8027 |
CYP450 1A2 Inhibitor | Non-inhibitor | 0.8641 |
CYP450 2C9 Inhibitor | Non-inhibitor | 0.9741 |
CYP450 2D6 Inhibitor | Non-inhibitor | 0.9791 |
CYP450 2C19 Inhibitor | Non-inhibitor | 0.9800 |
CYP450 3A4 Inhibitor | Non-inhibitor | 0.9876 |
CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | 0.9511 |
Excretion | ||
Toxicity | ||
Human Ether-a-go-go-Related Gene Inhibition | Weak inhibitor | 0.9511 |
Non-inhibitor | 0.9805 | |
AMES Toxicity | Non AMES toxic | 0.6375 |
Carcinogens | Carcinogens | 0.6803 |
Fish Toxicity | Low FHMT | 0.6158 |
Tetrahymena Pyriformis Toxicity | High TPT | 0.8581 |
Honey Bee Toxicity | High HBT | 0.7938 |
Biodegradation | Ready biodegradable | 0.7562 |
Acute Oral Toxicity | III | 0.8284 |
Carcinogenicity (Three-class) | Non-required | 0.6767 |
From admetSAR
ADMET Predicted Profile --- Regression
Model | Value | Unit |
---|---|---|
Absorption | ||
Aqueous solubility | 0.8143 | LogS |
Caco-2 Permeability | 1.5492 | LogPapp, cm/s |
Distribution | ||
Metabolism | ||
Excretion | ||
Toxicity | ||
Rat Acute Toxicity | 1.8556 | LD50, mol/kg |
Fish Toxicity | 1.6543 | pLC50, mg/L |
Tetrahymena Pyriformis Toxicity | -0.3413 | pIGC50, ug/L |
From admetSAR
Toxicity Profile
Route of Exposure | |
---|---|
Mechanism of Toxicity | Acetaldehyde can form adducts with DNA, causing damage such as cross-links. |
Metabolism | In the liver, the enzyme acetaldehyde dehydrogenase converts acetaldehyde into the harmless compound acetic acid. |
Toxicity Values | LD50: 661 mg/kg (Oral, Rat) LD50: 212 mg/kg (Intravenous, Mouse) LD50: 3540 mg/kg (Dermal, Rabbit) LD50: 640 mg/kg (Subcutaneous, Rat) LD50: 96 mg/kg (Intratracheal, Hamster) LD50: 500 mg/kg (Intraperitoneal, Mouse) LC50: 1500 ppm over 4 hours (Inhalation, Mouse) |
Lethal Dose | |
Carcinogenicity (IARC Classification) | 2B, possibly carcinogenic to humans. Acetaldehyde associated with consumption of alcoholic beverages is carcinogenic to humans (Group 1). |
Minimum Risk Level | |
Health Effects | Acetaldehyde is a probable carcinogen. (L1307) |
Treatment | |
Reference |
|
From T3DB
Taxonomic Classification
Kingdom | Organic compounds |
---|---|
Superclass | Organic oxygen compounds |
Class | Organooxygen compounds |
Subclass | Carbonyl compounds |
Intermediate Tree Nodes | Aldehydes |
Direct Parent | Short-chain aldehydes |
Alternative Parents | |
Molecular Framework | Aliphatic acyclic compounds |
Substituents | Organic oxide - Hydrocarbon derivative - Short-chain aldehyde - Aliphatic acyclic compound |
Description | This compound belongs to the class of organic compounds known as short-chain aldehydes. These are an aldehyde with a chain length containing between 2 and 5 carbon atoms. |
From ClassyFire
Targets
- General Function:
- Aldehyde dehydrogenase [nad(p)+] activity
- Specific Function:
- Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation.
- Gene Name:
- ALDH3B1
- Uniprot ID:
- P43353
- Molecular Weight:
- 51839.245 Da
References
- Marchitti SA, Brocker C, Orlicky DJ, Vasiliou V: Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress. Free Radic Biol Med. 2010 Nov 15;49(9):1432-43. doi: 10.1016/j.freeradbiomed.2010.08.004. Epub 2010 Aug 10. [20699116 ]
From T3DB