RIBOFLAVIN 5'-PHOSPHATE
General Information
| Mainterm | RIBOFLAVIN 5'-PHOSPHATE |
| Doc Type | EAF |
| CAS Reg.No.(or other ID) | 146-17-8 |
| Regnum |
From www.fda.gov
Computed Descriptors
Download SDF| 2D Structure | |
| CID | 643976 |
| IUPAC Name | [(2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl] dihydrogen phosphate |
| InChI | InChI=1S/C17H21N4O9P/c1-7-3-9-10(4-8(7)2)21(15-13(18-9)16(25)20-17(26)19-15)5-11(22)14(24)12(23)6-30-31(27,28)29/h3-4,11-12,14,22-24H,5-6H2,1-2H3,(H,20,25,26)(H2,27,28,29)/t11-,12+,14-/m0/s1 |
| InChI Key | FVTCRASFADXXNN-SCRDCRAPSA-N |
| Canonical SMILES | CC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)CC(C(C(COP(=O)(O)O)O)O)O |
| Molecular Formula | C17H21N4O9P |
| Wikipedia | flavin mononucleotide |
From Pubchem
Computed Properties
| Property Name | Property Value |
|---|---|
| Molecular Weight | 456.348 |
| Hydrogen Bond Donor Count | 6 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 7 |
| Complexity | 844.0 |
| CACTVS Substructure Key Fingerprint | A A A D c e B 7 v A I A A A A A A A A A A A A A A A A A A A A A A A A w Q I A A A A A A A A C B A A A A H g A Q C C A A D B z h m A Y z w I P A A x C o Q y d y d I C C A A E h A g A B i A E o d I i L c C r A 2 Z G U Y A h n h S L Z y A f w k I I O i A A A Q A A Q A C A Q A A C A A C A A Q A A A A A A A A A = = |
| Topological Polar Surface Area | 202.0 |
| Monoisotopic Mass | 456.105 |
| Exact Mass | 456.105 |
| Compound Is Canonicalized | True |
| Formal Charge | 0 |
| Heavy Atom Count | 31 |
| Defined Atom Stereocenter Count | 3 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Isotope Atom Count | 0 |
| Covalently-Bonded Unit Count | 1 |
From Pubchem
Food Additives Biosynthesis/Degradation
ADMET Predicted Profile --- Classification
| Model | Result | Probability |
|---|---|---|
| Absorption | ||
| Blood-Brain Barrier | BBB- | 0.7057 |
| Human Intestinal Absorption | HIA- | 0.9125 |
| Caco-2 Permeability | Caco2- | 0.6779 |
| P-glycoprotein Substrate | Substrate | 0.7661 |
| P-glycoprotein Inhibitor | Non-inhibitor | 0.7188 |
| Non-inhibitor | 0.9704 | |
| Renal Organic Cation Transporter | Non-inhibitor | 0.9373 |
| Distribution | ||
| Subcellular localization | Mitochondria | 0.5445 |
| Metabolism | ||
| CYP450 2C9 Substrate | Non-substrate | 0.7163 |
| CYP450 2D6 Substrate | Non-substrate | 0.8210 |
| CYP450 3A4 Substrate | Substrate | 0.5230 |
| CYP450 1A2 Inhibitor | Non-inhibitor | 0.6006 |
| CYP450 2C9 Inhibitor | Non-inhibitor | 0.8359 |
| CYP450 2D6 Inhibitor | Non-inhibitor | 0.8907 |
| CYP450 2C19 Inhibitor | Non-inhibitor | 0.6667 |
| CYP450 3A4 Inhibitor | Non-inhibitor | 0.7421 |
| CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | 0.8922 |
| Excretion | ||
| Toxicity | ||
| Human Ether-a-go-go-Related Gene Inhibition | Weak inhibitor | 0.9468 |
| Inhibitor | 0.5840 | |
| AMES Toxicity | Non AMES toxic | 0.7160 |
| Carcinogens | Non-carcinogens | 0.8096 |
| Fish Toxicity | High FHMT | 0.6121 |
| Tetrahymena Pyriformis Toxicity | High TPT | 0.9830 |
| Honey Bee Toxicity | Low HBT | 0.6703 |
| Biodegradation | Not ready biodegradable | 0.9737 |
| Acute Oral Toxicity | III | 0.5333 |
| Carcinogenicity (Three-class) | Non-required | 0.6048 |
From admetSAR
ADMET Predicted Profile --- Regression
| Model | Value | Unit |
|---|---|---|
| Absorption | ||
| Aqueous solubility | -3.5962 | LogS |
| Caco-2 Permeability | -0.5209 | LogPapp, cm/s |
| Distribution | ||
| Metabolism | ||
| Excretion | ||
| Toxicity | ||
| Rat Acute Toxicity | 2.4314 | LD50, mol/kg |
| Fish Toxicity | 1.5693 | pLC50, mg/L |
| Tetrahymena Pyriformis Toxicity | 0.4867 | pIGC50, ug/L |
From admetSAR
Taxonomic Classification
| Kingdom | Organic compounds |
|---|---|
| Superclass | Nucleosides, nucleotides, and analogues |
| Class | Flavin nucleotides |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Flavin nucleotides |
| Alternative Parents | |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Flavin nucleotide - Flavin - Isoalloxazine - Diazanaphthalene - Pteridine - Quinoxaline - Monoalkyl phosphate - Pyrimidone - Pyrazine - Organic phosphoric acid derivative - Phosphoric acid ester - Benzenoid - Alkyl phosphate - Pyrimidine - Heteroaromatic compound - Vinylogous amide - Secondary alcohol - Lactam - Azacycle - Polyol - Organoheterocyclic compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Alcohol - Organic nitrogen compound - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as flavin nucleotides. These are nucleotides containing a flavin moiety. Flavin is a compound that contains the tricyclic isoalloxazine ring system, which bears 2 oxo groups at the 2- and 4-positions. |
From ClassyFire
Targets
- General Function:
- Trimethylamine dehydrogenase activity
- Gene Name:
- tmd
- Uniprot ID:
- P16099
- Molecular Weight:
- 81628.615 Da
- General Function:
- Oxidoreductase activity
- Specific Function:
- Catalyzes the four-electron reduction of one oxygen molecule to two water molecules.
- Gene Name:
- roo
- Uniprot ID:
- Q9F0J6
- Molecular Weight:
- 44796.045 Da
- General Function:
- Riboflavin kinase activity
- Uniprot ID:
- Q9WZW1
- Molecular Weight:
- 33613.56 Da
- General Function:
- Oxidoreductase activity
- Gene Name:
- morB
- Uniprot ID:
- Q51990
- Molecular Weight:
- 41249.71 Da
- General Function:
- Oxidoreductase activity
- Specific Function:
- Involved in bioluminescence. It is a good supplier of reduced flavin mononucleotide (FMNH2) to the bioluminescence reaction.
- Gene Name:
- frp
- Uniprot ID:
- Q56691
- Molecular Weight:
- 26309.475 Da
- General Function:
- Ribosomal protein s6 kinase activity
- Specific Function:
- Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.
- Gene Name:
- RPS6KA4
- Uniprot ID:
- O75676
- Molecular Weight:
- 85605.025 Da
- General Function:
- Pyridoxamine-phosphate oxidase activity
- Specific Function:
- Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control. Probably catalyzes the final step in the conversion of trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA) to phenazine-1-carboxylic acid (PCA).
- Gene Name:
- phzG
- Uniprot ID:
- Q51793
- Molecular Weight:
- 24934.955 Da
- General Function:
- Very-long-chain-(s)-2-hydroxy-acid oxidase activity
- Specific Function:
- Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.
- Gene Name:
- HAO2
- Uniprot ID:
- Q9NYQ3
- Molecular Weight:
- 38838.35 Da
- General Function:
- Nad(p)h dehydrogenase (quinone) activity
- Specific Function:
- It seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing. It reduces quinones to the hydroquinone state to prevent interaction of the semiquinone with O2 and production of superoxide (By similarity).
- Uniprot ID:
- Q9RYU4
- Molecular Weight:
- 21297.875 Da
- General Function:
- Fmn binding
- Specific Function:
- Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase.
- Gene Name:
- fldA
- Uniprot ID:
- P61949
- Molecular Weight:
- 19736.735 Da
- General Function:
- Oxidoreductase activity
- Specific Function:
- Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
- Gene Name:
- fni
- Uniprot ID:
- P50740
- Molecular Weight:
- 37220.19 Da
- General Function:
- Nadh dehydrogenase activity
- Specific Function:
- Can oxidize either NADH or NADPH with a preference for NADH. Can catalyze electron transfer from NADH to various electron acceptors which include, in addition to molecular oxygen, cytochrome c, 2,6 dichlorphenolindophenol, methylene blue, ferricyanide or P-nitroblue tetrazolium.
- Gene Name:
- nox
- Uniprot ID:
- Q60049
- Molecular Weight:
- 22730.15 Da
- General Function:
- Pyridoxamine-phosphate oxidase activity
- Specific Function:
- Functions as a redox protein with a potential of -325 mV.
- Uniprot ID:
- Q46604
- Molecular Weight:
- 13137.025 Da
- General Function:
- Oxidoreductase activity
- Uniprot ID:
- Q81EW9
- Molecular Weight:
- 22822.865 Da
- General Function:
- Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
- Specific Function:
- This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
- Gene Name:
- POR
- Uniprot ID:
- P16435
- Molecular Weight:
- 76689.12 Da
- General Function:
- Phosphopantothenoylcysteine decarboxylase activity
- Specific Function:
- Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.
- Gene Name:
- PPCDC
- Uniprot ID:
- Q96CD2
- Molecular Weight:
- 22394.965 Da
- General Function:
- Pyridoxamine-phosphate oxidase activity
- Specific Function:
- Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
- Gene Name:
- phzG
- Uniprot ID:
- O69755
- Molecular Weight:
- 24268.005 Da
- General Function:
- Metal ion binding
- Gene Name:
- gltS
- Uniprot ID:
- P55038
- Molecular Weight:
- 169497.705 Da
- General Function:
- Pyridoxamine-phosphate oxidase activity
- Specific Function:
- Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
- Gene Name:
- pdxH
- Uniprot ID:
- P0AFI7
- Molecular Weight:
- 25544.975 Da
- General Function:
- Fmn binding
- Specific Function:
- Low-potential electron donor to a number of redox enzymes.
- Uniprot ID:
- P00322
- Molecular Weight:
- 15332.225 Da
- General Function:
- Nad(p)h nitroreductase activity
- Specific Function:
- Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone, quinones and the anti-tumor agent CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species.
- Gene Name:
- nfsB
- Uniprot ID:
- P38489
- Molecular Weight:
- 23904.99 Da
- General Function:
- Chorismate synthase activity
- Specific Function:
- Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
- Gene Name:
- aroC
- Uniprot ID:
- P0A2Y7
- Molecular Weight:
- 42871.475 Da
- General Function:
- Nadph dehydrogenase activity
- Specific Function:
- Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-2- enoyl-CoA.
- Gene Name:
- fadH
- Uniprot ID:
- P42593
- Molecular Weight:
- 72677.545 Da
- General Function:
- Dihydroorotate dehydrogenase (fumarate) activity
- Specific Function:
- Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.
- Gene Name:
- pyrDA
- Uniprot ID:
- Q53ZE5
- Molecular Weight:
- 34209.99 Da
- General Function:
- Riboflavin reductase (nadph) activity
- Specific Function:
- Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.
- Gene Name:
- BLVRB
- Uniprot ID:
- P30043
- Molecular Weight:
- 22119.215 Da
- General Function:
- Very-long-chain-(s)-2-hydroxy-acid oxidase activity
- Specific Function:
- Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
- Gene Name:
- HAO1
- Uniprot ID:
- Q9UJM8
- Molecular Weight:
- 40923.945 Da
- General Function:
- Pyridoxamine-phosphate oxidase activity
- Specific Function:
- Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
- Gene Name:
- PNPO
- Uniprot ID:
- Q9NVS9
- Molecular Weight:
- 29987.79 Da
- General Function:
- Oxidoreductase activity
- Specific Function:
- Involved in bioluminescence. It is a good supplier of reduced flavin mononucleotide (FMNH2) to the bioluminescence reaction. Major FMN reductase. It is capable of using both NADH and NADPH as electron donors. As electron acceptor, FMN is the most effective, FAD is considerably effective, and riboflavin is the least effective.
- Uniprot ID:
- P46072
- Molecular Weight:
- 24720.685 Da
- General Function:
- Riboflavin kinase activity
- Specific Function:
- Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.
- Gene Name:
- RFK
- Uniprot ID:
- Q969G6
- Molecular Weight:
- 17623.08 Da
- General Function:
- Oxidoreductase activity, acting on nad(p)h, nitrogenous group as acceptor
- Specific Function:
- Reduction of nitroaromatic compounds using NADH. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. Major component of the oxygen-insensitive nitroreductase activity in E.coli.
- Gene Name:
- nfsA
- Uniprot ID:
- P17117
- Molecular Weight:
- 26800.375 Da
- General Function:
- Tetrahydrobiopterin binding
- Specific Function:
- Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
- Gene Name:
- NOS1
- Uniprot ID:
- P29475
- Molecular Weight:
- 160969.095 Da
- General Function:
- Fmn binding
- Specific Function:
- Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
- Gene Name:
- pyrD
- Uniprot ID:
- P0A7E1
- Molecular Weight:
- 36774.185 Da
- General Function:
- Protein homodimerization activity
- Specific Function:
- Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
- Gene Name:
- DPYD
- Uniprot ID:
- Q12882
- Molecular Weight:
- 111400.32 Da
- General Function:
- Ubiquinone binding
- Specific Function:
- Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
- Gene Name:
- DHODH
- Uniprot ID:
- Q02127
- Molecular Weight:
- 42866.93 Da
- General Function:
- Oxidoreductase activity
- Gene Name:
- onr
- Uniprot ID:
- P71278
- Molecular Weight:
- 39488.93 Da
- General Function:
- Oxidoreductase activity, acting on other nitrogenous compounds as donors
- Specific Function:
- Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity.
- Gene Name:
- azoR
- Uniprot ID:
- P63462
- Molecular Weight:
- 21627.63 Da
- General Function:
- Lyase activity
- Specific Function:
- Catalyzes the removal of two reducing equivalents (oxidative decarboxylation) from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond.
- Gene Name:
- epiD
- Uniprot ID:
- P30197
- Molecular Weight:
- 20824.89 Da
- General Function:
- Oxidoreductase activity, acting on nad(p)h, quinone or similar compound as acceptor
- Specific Function:
- Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity. The enzyme can reduce ethyl red and methyl red, but is not able to convert sulfonated azo dyes.
- Gene Name:
- azoR
- Uniprot ID:
- P41407
- Molecular Weight:
- 21657.47 Da
- General Function:
- Fmn binding
- Specific Function:
- Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
- Gene Name:
- aroC
- Uniprot ID:
- P56122
- Molecular Weight:
- 40099.6 Da
- General Function:
- Fmn binding
- Specific Function:
- Low-potential electron donor to a number of redox enzymes.
- Gene Name:
- isiB
- Uniprot ID:
- P0A3D9
- Molecular Weight:
- 18963.675 Da
- General Function:
- Iron ion binding
- Specific Function:
- Low-potential electron donor to a number of redox enzymes.
- Uniprot ID:
- P00323
- Molecular Weight:
- 15823.215 Da
- General Function:
- Fmn binding
- Specific Function:
- Low-potential electron donor to a number of redox enzymes.
- Gene Name:
- isiB
- Uniprot ID:
- P10340
- Molecular Weight:
- 18777.495 Da
- General Function:
- Oxidoreductase activity
- Uniprot ID:
- Q8DW21
- Molecular Weight:
- 22384.165 Da
- General Function:
- Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
- Specific Function:
- May play a role in methionine degradation. May play a role in a sulfur salvage pathway.
- Gene Name:
- moxC
- Uniprot ID:
- O34974
- Molecular Weight:
- 49410.955 Da
- General Function:
- Trna dihydrouridine synthase activity
- Specific Function:
- Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.
- Uniprot ID:
- Q9WXV1
- Molecular Weight:
- 35149.495 Da
- Specific Function:
- Probably involved in ribonucleotide reductase function.
- Gene Name:
- nrdI
- Uniprot ID:
- P50618
- Molecular Weight:
- 14602.575 Da
- General Function:
- Prenyltransferase activity
- Specific Function:
- Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for phenolic acid decarboxylase C (By similarity). Involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions (PubMed:15979273).
- Gene Name:
- ecdB
- Uniprot ID:
- P69772
- Molecular Weight:
- 21469.72 Da
- General Function:
- Fmn binding
- Specific Function:
- Reduction of (S)-mandelate to benzoylformate.
- Gene Name:
- mdlB
- Uniprot ID:
- P20932
- Molecular Weight:
- 43436.53 Da
- General Function:
- Oxidoreductase activity
- Specific Function:
- Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADPH, but not NADH, as an electron donor for its activity.
- Gene Name:
- azr
- Uniprot ID:
- O07529
- Molecular Weight:
- 18903.755 Da
- General Function:
- Fmn binding
- Specific Function:
- Low-potential electron donor to a number of redox enzymes.
- Gene Name:
- fldA
- Uniprot ID:
- Q9ZK53
- Molecular Weight:
- 17473.305 Da
- General Function:
- Sodium channel regulator activity
- Specific Function:
- Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1.
- Gene Name:
- SGK1
- Uniprot ID:
- O00141
- Molecular Weight:
- 48941.96 Da
- General Function:
- Oxidoreductase activity
- Specific Function:
- Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred.
- Gene Name:
- nfsB
- Uniprot ID:
- Q01234
- Molecular Weight:
- 23949.98 Da
- General Function:
- Oxidoreductase activity
- Specific Function:
- Has nitric oxide reductase activity in combination with Hrb; probably involved in nitrosative stress protection.
- Gene Name:
- fprA
- Uniprot ID:
- Q9FDN7
- Molecular Weight:
- 44296.64 Da
- General Function:
- Oxidoreductase activity
- Specific Function:
- Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
- Gene Name:
- fni
- Uniprot ID:
- Q746I8
- Molecular Weight:
- 35900.305 Da
From T3DB