PHENETHYL ISOTHIOCYANATE
Relevant Data
Food Additives Approved by WHO:
Flavouring Substances Approved by European Union:
General Information
| Mainterm | PHENETHYL ISOTHIOCYANATE |
| Doc Type | EAF |
| CAS Reg.No.(or other ID) | 2257-09-2 |
| Regnum |
From www.fda.gov
Computed Descriptors
Download SDF| 2D Structure | |
| CID | 16741 |
| IUPAC Name | 2-isothiocyanatoethylbenzene |
| InChI | InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2 |
| InChI Key | IZJDOKYDEWTZSO-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC=C(C=C1)CCN=C=S |
| Molecular Formula | C9H9NS |
| Wikipedia | phenethyl isothiocyanate |
From Pubchem
Computed Properties
| Property Name | Property Value |
|---|---|
| Molecular Weight | 163.238 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 3 |
| Complexity | 144.0 |
| CACTVS Substructure Key Fingerprint | A A A D c c B y A A B A A A A A A A A A A A A A A A A A A A A A A A A w A A A A A A A A A A A B A A A A H A Q A A A A A D A D B G A Q w A I I A A A C k A i B C B A A C A A A g A A A I i A A A A I g I I C K A k R G A I A A g g A A I i A c Q g I A O A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A = = |
| Topological Polar Surface Area | 44.4 |
| Monoisotopic Mass | 163.046 |
| Exact Mass | 163.046 |
| Compound Is Canonicalized | True |
| Formal Charge | 0 |
| Heavy Atom Count | 11 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Isotope Atom Count | 0 |
| Covalently-Bonded Unit Count | 1 |
From Pubchem
ADMET Predicted Profile --- Classification
| Model | Result | Probability |
|---|---|---|
| Absorption | ||
| Blood-Brain Barrier | BBB+ | 0.9454 |
| Human Intestinal Absorption | HIA+ | 0.8885 |
| Caco-2 Permeability | Caco2+ | 0.7309 |
| P-glycoprotein Substrate | Non-substrate | 0.8099 |
| P-glycoprotein Inhibitor | Non-inhibitor | 0.9049 |
| Non-inhibitor | 0.9643 | |
| Renal Organic Cation Transporter | Inhibitor | 0.6378 |
| Distribution | ||
| Subcellular localization | Lysosome | 0.5035 |
| Metabolism | ||
| CYP450 2C9 Substrate | Non-substrate | 0.8262 |
| CYP450 2D6 Substrate | Non-substrate | 0.5889 |
| CYP450 3A4 Substrate | Non-substrate | 0.7313 |
| CYP450 1A2 Inhibitor | Inhibitor | 0.8132 |
| CYP450 2C9 Inhibitor | Non-inhibitor | 0.8521 |
| CYP450 2D6 Inhibitor | Non-inhibitor | 0.6419 |
| CYP450 2C19 Inhibitor | Non-inhibitor | 0.5802 |
| CYP450 3A4 Inhibitor | Non-inhibitor | 0.7896 |
| CYP Inhibitory Promiscuity | High CYP Inhibitory Promiscuity | 0.5811 |
| Excretion | ||
| Toxicity | ||
| Human Ether-a-go-go-Related Gene Inhibition | Weak inhibitor | 0.7609 |
| Non-inhibitor | 0.9072 | |
| AMES Toxicity | AMES toxic | 0.9107 |
| Carcinogens | Non-carcinogens | 0.6701 |
| Fish Toxicity | High FHMT | 0.5571 |
| Tetrahymena Pyriformis Toxicity | High TPT | 0.9977 |
| Honey Bee Toxicity | High HBT | 0.6307 |
| Biodegradation | Not ready biodegradable | 0.9909 |
| Acute Oral Toxicity | II | 0.6776 |
| Carcinogenicity (Three-class) | Non-required | 0.7605 |
From admetSAR
ADMET Predicted Profile --- Regression
| Model | Value | Unit |
|---|---|---|
| Absorption | ||
| Aqueous solubility | -1.9486 | LogS |
| Caco-2 Permeability | 1.7683 | LogPapp, cm/s |
| Distribution | ||
| Metabolism | ||
| Excretion | ||
| Toxicity | ||
| Rat Acute Toxicity | 2.6621 | LD50, mol/kg |
| Fish Toxicity | 1.8353 | pLC50, mg/L |
| Tetrahymena Pyriformis Toxicity | 2.6652 | pIGC50, ug/L |
From admetSAR
Taxonomic Classification
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Benzene and substituted derivatives |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Benzene and substituted derivatives |
| Alternative Parents | |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Monocyclic benzene moiety - Isothiocyanate - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organosulfur compound - Organonitrogen compound - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene. |
From ClassyFire
Targets
- General Function:
- Protein kinase binding
- Specific Function:
- Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
- Gene Name:
- ACTA2
- Uniprot ID:
- P62736
- Molecular Weight:
- 42008.57 Da
- General Function:
- Tat protein binding
- Specific Function:
- Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
- Gene Name:
- ACTB
- Uniprot ID:
- P60709
- Molecular Weight:
- 41736.37 Da
- General Function:
- Transporter activity
- Specific Function:
- Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
- Gene Name:
- ATP5B
- Uniprot ID:
- P06576
- Molecular Weight:
- 56559.42 Da
- General Function:
- Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
- Specific Function:
- Hydrogen ion transmembrane transporter activity
- Gene Name:
- ATP5I
- Uniprot ID:
- P56385
- Molecular Weight:
- 7933.11 Da
- General Function:
- Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
- Specific Function:
- Hydrogen ion transmembrane transporter activity
- Gene Name:
- ATP5L
- Uniprot ID:
- O75964
- Molecular Weight:
- 11428.4 Da
- General Function:
- Metal ion binding
- Specific Function:
- Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.
- Gene Name:
- CYB5B
- Uniprot ID:
- O43169
- Molecular Weight:
- 16332.005 Da
- General Function:
- Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
- Gene Name:
- DIABLO
- Uniprot ID:
- Q9NR28
- Molecular Weight:
- 27130.58 Da
- General Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
- Specific Function:
- Ubiquitin-protein transferase activity
- Gene Name:
- FBXO41
- Uniprot ID:
- Q8TF61
- Molecular Weight:
- 94495.26 Da
- General Function:
- Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.
- Specific Function:
- Rna binding
- Gene Name:
- HNRNPF
- Uniprot ID:
- P52597
- Molecular Weight:
- 45671.61 Da
- General Function:
- One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
- Specific Function:
- Cadherin binding
- Gene Name:
- HNRNPK
- Uniprot ID:
- P61978
- Molecular Weight:
- 50975.81 Da
- Specific Function:
- Atp binding
- Gene Name:
- HSPA4
- Uniprot ID:
- P34932
- Molecular Weight:
- 94330.225 Da
- General Function:
- Ubiquitin binding
- Specific Function:
- Involved in stress resistance and actin organization.
- Gene Name:
- HSPB1
- Uniprot ID:
- P04792
- Molecular Weight:
- 22782.3 Da
- General Function:
- Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:7912672, PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable).
- Specific Function:
- Atp binding
- Gene Name:
- HSPE1
- Uniprot ID:
- P61604
- Molecular Weight:
- 10931.645 Da
- General Function:
- Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).
- Specific Function:
- Adenyl-nucleotide exchange factor activity
- Gene Name:
- HSPH1
- Uniprot ID:
- Q92598
- Molecular Weight:
- 96864.305 Da
- General Function:
- Nadh dehydrogenase (ubiquinone) activity
- Specific Function:
- Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
- Gene Name:
- MT-ND1
- Uniprot ID:
- P03886
- Molecular Weight:
- 35660.055 Da
- General Function:
- Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
- Specific Function:
- Cadherin binding
- Gene Name:
- NUDC
- Uniprot ID:
- Q9Y266
- Molecular Weight:
- 38242.7 Da
- General Function:
- Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
- Specific Function:
- Metalloendopeptidase activity
- Gene Name:
- PAPPA
- Uniprot ID:
- Q13219
- Molecular Weight:
- 180971.11 Da
- General Function:
- Threonine-type endopeptidase activity
- Specific Function:
- The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
- Gene Name:
- PSMA3
- Uniprot ID:
- P25788
- Molecular Weight:
- 28432.97 Da
- General Function:
- Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
- Specific Function:
- Atp binding
- Gene Name:
- PSMC3
- Uniprot ID:
- P17980
- Molecular Weight:
- 49203.11 Da
- General Function:
- Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.
- Specific Function:
- Cadherin binding
- Gene Name:
- RANBP1
- Uniprot ID:
- P43487
- Molecular Weight:
- 23309.92 Da
- General Function:
- Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
- Specific Function:
- Calcium ion binding
- Gene Name:
- S100A10
- Uniprot ID:
- P60903
- Molecular Weight:
- 11203.06 Da
- General Function:
- Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
- Specific Function:
- Rna binding
- Gene Name:
- SF3A3
- Uniprot ID:
- Q12874
- Molecular Weight:
- 58848.42 Da
- General Function:
- Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells.
- Specific Function:
- Chromatin binding
- Gene Name:
- SMARCE1
- Uniprot ID:
- Q969G3
- Molecular Weight:
- 46649.09 Da
- General Function:
- Succinate-coa ligase (gdp-forming) activity
- Specific Function:
- Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA.
- Gene Name:
- SUCLG2
- Uniprot ID:
- Q96I99
- Molecular Weight:
- 46510.215 Da
- Specific Function:
- Protein heterodimerization activity
- Gene Name:
- TPD52L2
- Uniprot ID:
- O43399
- Molecular Weight:
- 22237.535 Da
- General Function:
- Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
- Specific Function:
- Actin binding
- Gene Name:
- TPM1
- Uniprot ID:
- P09493
- Molecular Weight:
- 32708.175 Da
- General Function:
- Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
- Specific Function:
- Actin filament binding
- Gene Name:
- TPM3
- Uniprot ID:
- P06753
- Molecular Weight:
- 32949.61 Da
- General Function:
- Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.
- Specific Function:
- Actin filament binding
- Gene Name:
- TPM4
- Uniprot ID:
- P67936
- Molecular Weight:
- 28521.535 Da
- General Function:
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
- Specific Function:
- Gtp binding
- Gene Name:
- TUBA1A
- Uniprot ID:
- Q71U36
- Molecular Weight:
- 50135.25 Da
- General Function:
- Structural constituent of cytoskeleton
- Specific Function:
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
- Gene Name:
- TUBA3C
- Uniprot ID:
- Q13748
- Molecular Weight:
- 49959.145 Da
- General Function:
- Structural constituent of cytoskeleton
- Specific Function:
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
- Gene Name:
- TUBA4A
- Uniprot ID:
- P68366
- Molecular Weight:
- 49923.995 Da
- General Function:
- Structural constituent of cytoskeleton
- Specific Function:
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
- Gene Name:
- TUBB1
- Uniprot ID:
- Q9H4B7
- Molecular Weight:
- 50326.56 Da
- General Function:
- Structural constituent of cytoskeleton
- Specific Function:
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
- Gene Name:
- TUBB2A
- Uniprot ID:
- Q13885
- Molecular Weight:
- 49906.67 Da
- General Function:
- Structural constituent of cytoskeleton
- Specific Function:
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance.
- Gene Name:
- TUBB3
- Uniprot ID:
- Q13509
- Molecular Weight:
- 50432.355 Da
- General Function:
- Unfolded protein binding
- Specific Function:
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
- Gene Name:
- TUBB4B
- Uniprot ID:
- P68371
- Molecular Weight:
- 49830.72 Da
- General Function:
- Protein disulfide oxidoreductase activity
- Specific Function:
- Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
- Gene Name:
- TXN
- Uniprot ID:
- P10599
- Molecular Weight:
- 11737.42 Da
- General Function:
- Ubiquitin-specific protease activity
- Specific Function:
- Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
- Gene Name:
- UCHL1
- Uniprot ID:
- P09936
- Molecular Weight:
- 24824.17 Da
- General Function:
- Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).
- Specific Function:
- Cysteine-type endopeptidase activity
- Gene Name:
- USP14
- Uniprot ID:
- P54578
- Molecular Weight:
- 56068.665 Da
- Gene Name:
- VCP
- Uniprot ID:
- P55072
- Molecular Weight:
- 89320.885 Da
- General Function:
- Structural constituent of eye lens
- Specific Function:
- Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
- Gene Name:
- VIM
- Uniprot ID:
- P08670
- Molecular Weight:
- 53651.165 Da
- General Function:
- Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
- Specific Function:
- Cadherin binding
- Gene Name:
- YWHAB
- Uniprot ID:
- P31946
- Molecular Weight:
- 28082.165 Da
- General Function:
- Ubiquitin protein ligase binding
- Specific Function:
- Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
- Gene Name:
- YWHAE
- Uniprot ID:
- P62258
- Molecular Weight:
- 29173.58 Da
- General Function:
- Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
- Specific Function:
- Actin binding
- Gene Name:
- YWHAH
- Uniprot ID:
- Q04917
- Molecular Weight:
- 28218.445 Da
- General Function:
- Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
- Specific Function:
- 14-3-3 protein binding
- Gene Name:
- YWHAQ
- Uniprot ID:
- P27348
- Molecular Weight:
- 27763.93 Da
- General Function:
- Ubiquitin protein ligase binding
- Specific Function:
- Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
- Gene Name:
- YWHAZ
- Uniprot ID:
- P63104
- Molecular Weight:
- 27744.84 Da
From T3DB