CARBON MONOXIDE
General Information
| Mainterm | CARBON MONOXIDE |
| CAS Reg.No.(or other ID) | 630-08-0 |
| Regnum |
175.105 177.1312 178.1005 |
From www.fda.gov
Computed Descriptors
Download SDF| 2D Structure | |
| CID | 281 |
| IUPAC Name | carbon monoxide |
| InChI | InChI=1S/CO/c1-2 |
| InChI Key | UGFAIRIUMAVXCW-UHFFFAOYSA-N |
| Canonical SMILES | [C-]#[O+] |
| Molecular Formula | CO |
| Wikipedia | carbon monoxide |
From Pubchem
Computed Properties
| Property Name | Property Value |
|---|---|
| Molecular Weight | 28.01 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Complexity | 10.0 |
| CACTVS Substructure Key Fingerprint | A A A D c Q A A I A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A g A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A = = |
| Topological Polar Surface Area | 1.0 |
| Monoisotopic Mass | 27.995 |
| Exact Mass | 27.995 |
| XLogP3 | None |
| XLogP3-AA | 0.7 |
| Compound Is Canonicalized | True |
| Formal Charge | 0 |
| Heavy Atom Count | 2 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Isotope Atom Count | 0 |
| Covalently-Bonded Unit Count | 1 |
From Pubchem
Food Additives Biosynthesis/Degradation
Toxicity Profile
| Route of Exposure | Inhalation |
|---|---|
| Mechanism of Toxicity | Carbon monoxide possesses a higher affinity than oxygen for hemoglobin, leading to the formation of carboxyhemoglobin, this provoking anoxemia. Carbon monoxide also binds to myoglobin, impairing its ability to utilize oxygen. It can also bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. Carbon monoxide also causes endothelial cell and platelet release of nitric oxide, and the formation of oxygen free radicals. This results in lipid peroxidation, leading to edema and necrosis within the brain. |
| Metabolism | |
| Toxicity Values | |
| Lethal Dose | 5000 ppm over 5 minutes for an adult human. |
| Carcinogenicity (IARC Classification) | No indication of carcinogenicity to humans (not listed by IARC). |
| Minimum Risk Level | |
| Health Effects | Chronic exposure to low levels of carbon monoxide may cause persistent headaches, lightheadedness, depression, confusion, memory loss, and nausea and vomiting. (L961) |
| Treatment | Carbon monoxide poisoning is first treated by immediate removal from the source of exposure. High-flow or 100% oxygen should then be administered by a nonrebreather reservoir oxygen mask. Oxygen hastens the dissociation of carbon monoxide from hemoglobin, improving tissue oxygenation by reducing carbon monoxides biological half-life. Hyperbaric oxygen may also be used, as it increases carboxyhemoglobin dissociation to a greater extent than normal oxygen. |
| Reference |
|
From T3DB
Taxonomic Classification
| Kingdom | Inorganic compounds |
|---|---|
| Superclass | Homogeneous non-metal compounds |
| Class | Homogeneous other non-metal compounds |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Homogeneous other non-metal compounds |
| Alternative Parents |
|
| Molecular Framework | Not available |
| Substituents | Homogeneous other non metal |
| Description | This compound belongs to the class of inorganic compounds known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other non-metals'. |
From ClassyFire
Targets
- General Function:
- Oxygen transporter activity
- Specific Function:
- Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
- Gene Name:
- MB
- Uniprot ID:
- P02144
- Molecular Weight:
- 17183.725 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Iron ion binding
- Specific Function:
- Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
- Gene Name:
- MT-CO1
- Uniprot ID:
- P00395
- Molecular Weight:
- 57040.91 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
- Gene Name:
- MT-CO2
- Uniprot ID:
- P00403
- Molecular Weight:
- 25564.73 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- Subunits I, II and III form the functional core of the enzyme complex.
- Gene Name:
- MT-CO3
- Uniprot ID:
- P00414
- Molecular Weight:
- 29950.6 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX4I1
- Uniprot ID:
- P13073
- Molecular Weight:
- 19576.6 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX4I2
- Uniprot ID:
- Q96KJ9
- Molecular Weight:
- 20010.02 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Metal ion binding
- Specific Function:
- This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX5A
- Uniprot ID:
- P20674
- Molecular Weight:
- 16761.985 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Metal ion binding
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX5B
- Uniprot ID:
- P10606
- Molecular Weight:
- 13695.57 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX6A1
- Uniprot ID:
- P12074
- Molecular Weight:
- 12154.8 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX6A2
- Uniprot ID:
- Q02221
- Molecular Weight:
- 10815.32 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- Connects the two COX monomers into the physiological dimeric form.
- Gene Name:
- COX6B1
- Uniprot ID:
- P14854
- Molecular Weight:
- 10192.345 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- Connects the two COX monomers into the physiological dimeric form.
- Gene Name:
- COX6B2
- Uniprot ID:
- Q6YFQ2
- Molecular Weight:
- 10528.905 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX6C
- Uniprot ID:
- P09669
- Molecular Weight:
- 8781.36 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX7A1
- Uniprot ID:
- P24310
- Molecular Weight:
- 9117.44 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX7A2
- Uniprot ID:
- P14406
- Molecular Weight:
- 9395.89 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates.
- Gene Name:
- COX7B
- Uniprot ID:
- P24311
- Molecular Weight:
- 9160.485 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX7B2
- Uniprot ID:
- Q8TF08
- Molecular Weight:
- 9077.43 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX7C
- Uniprot ID:
- P15954
- Molecular Weight:
- 7245.45 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX8A
- Uniprot ID:
- P10176
- Molecular Weight:
- 7579.0 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX8C
- Uniprot ID:
- Q7Z4L0
- Molecular Weight:
- 8128.575 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Oxygen transporter activity
- Specific Function:
- Involved in oxygen transport from the lung to the various peripheral tissues.
- Gene Name:
- HBA1
- Uniprot ID:
- P69905
- Molecular Weight:
- 15257.405 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Oxygen transporter activity
- Specific Function:
- Involved in oxygen transport from the lung to the various peripheral tissues.LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.Spinorphin: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.
- Gene Name:
- HBB
- Uniprot ID:
- P68871
- Molecular Weight:
- 15998.34 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Oxygen transporter activity
- Specific Function:
- Involved in oxygen transport from the lung to the various peripheral tissues.
- Gene Name:
- HBD
- Uniprot ID:
- P02042
- Molecular Weight:
- 16055.41 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Oxygen transporter activity
- Specific Function:
- The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.
- Gene Name:
- HBE1
- Uniprot ID:
- P02100
- Molecular Weight:
- 16202.71 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Oxygen transporter activity
- Specific Function:
- Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
- Gene Name:
- HBG1
- Uniprot ID:
- P69891
- Molecular Weight:
- 16140.37 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
- Specific Function:
- Heme binding
- Gene Name:
- HBG2
- Uniprot ID:
- P69892
- Molecular Weight:
- 16126.35 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Oxygen transporter activity
- Gene Name:
- HBM
- Uniprot ID:
- Q6B0K9
- Molecular Weight:
- 15617.97 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Oxygen transporter activity
- Gene Name:
- HBQ1
- Uniprot ID:
- P09105
- Molecular Weight:
- 15507.575 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Oxygen transporter activity
- Specific Function:
- The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.
- Gene Name:
- HBZ
- Uniprot ID:
- P02008
- Molecular Weight:
- 15636.845 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
- General Function:
- Cytochrome-c oxidase activity
- Gene Name:
- COX7A2P2
- Uniprot ID:
- O60397
- Molecular Weight:
- 11840.715 Da
References
- Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. : http://en.wikipedia.org/wiki/Carbon_monoxide_poisoning
From T3DB