IODINE

General Function:

Metal ion binding

Specific Function:

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).

Gene Name:

ADCY1

Uniprot ID:

Q08828

Molecular Weight:

123438.85 Da

References

1. ATSDR - Agency for Toxic Substances and Disease Registry (2004). Toxicological profile for iodine. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).: http://www.atsdr.cdc.gov/toxprofiles/tp158.html

General Function:

Manganese ion binding

Specific Function:

Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (PubMed:17591988).

Gene Name:

ADCY10

Uniprot ID:

Q96PN6

Molecular Weight:

187147.545 Da

References

1. ATSDR - Agency for Toxic Substances and Disease Registry (2004). Toxicological profile for iodine. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).: http://www.atsdr.cdc.gov/toxprofiles/tp158.html

General Function:

Protein heterodimerization activity

Specific Function:

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).

Gene Name:

ADCY2

Uniprot ID:

Q08462

Molecular Weight:

123602.25 Da

References

1. ATSDR - Agency for Toxic Substances and Disease Registry (2004). Toxicological profile for iodine. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).: http://www.atsdr.cdc.gov/toxprofiles/tp158.html

General Function:

Metal ion binding

Specific Function:

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.

Gene Name:

ADCY3

Uniprot ID:

O60266

Molecular Weight:

128958.905 Da

References

1. ATSDR - Agency for Toxic Substances and Disease Registry (2004). Toxicological profile for iodine. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).: http://www.atsdr.cdc.gov/toxprofiles/tp158.html

General Function:

Metal ion binding

Specific Function:

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.

Gene Name:

ADCY4

Uniprot ID:

Q8NFM4

Molecular Weight:

119792.94 Da

References

1. ATSDR - Agency for Toxic Substances and Disease Registry (2004). Toxicological profile for iodine. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).: http://www.atsdr.cdc.gov/toxprofiles/tp158.html

General Function:

Protein heterodimerization activity

Specific Function:

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569).

Gene Name:

ADCY5

Uniprot ID:

O95622

Molecular Weight:

138906.37 Da

References

1. ATSDR - Agency for Toxic Substances and Disease Registry (2004). Toxicological profile for iodine. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).: http://www.atsdr.cdc.gov/toxprofiles/tp158.html

General Function:

Protein kinase binding

Specific Function:

Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (PubMed:17916776). Contributes to bone cell responses to mechanical stimuli (By similarity).

Gene Name:

ADCY6

Uniprot ID:

O43306

Molecular Weight:

130614.095 Da

References

1. ATSDR - Agency for Toxic Substances and Disease Registry (2004). Toxicological profile for iodine. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).: http://www.atsdr.cdc.gov/toxprofiles/tp158.html

General Function:

Metal ion binding

Specific Function:

This is a membrane-bound, calcium-inhibitable adenylyl cyclase.

Gene Name:

ADCY7

Uniprot ID:

P51828

Molecular Weight:

120307.175 Da

References

1. ATSDR - Agency for Toxic Substances and Disease Registry (2004). Toxicological profile for iodine. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).: http://www.atsdr.cdc.gov/toxprofiles/tp158.html

General Function:

Metal ion binding

Specific Function:

This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).

Gene Name:

ADCY8

Uniprot ID:

P40145

Molecular Weight:

140120.79 Da

References

1. ATSDR - Agency for Toxic Substances and Disease Registry (2004). Toxicological profile for iodine. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).: http://www.atsdr.cdc.gov/toxprofiles/tp158.html

General Function:

Metal ion binding

Specific Function:

Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827).

Gene Name:

ADCY9

Uniprot ID:

O60503

Molecular Weight:

150699.36 Da

References

1. ATSDR - Agency for Toxic Substances and Disease Registry (2004). Toxicological profile for iodine. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).: http://www.atsdr.cdc.gov/toxprofiles/tp158.html

General Function:

Nadh dehydrogenase (ubiquinone) activity

Specific Function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Gene Name:

MT-ND5

Uniprot ID:

P03915

Molecular Weight:

67025.67 Da