ZINC HYDROXIDE

General Information

Mainterm	ZINC HYDROXIDE
CAS Reg.No.(or other ID)	20427-58-1
Regnum	176.210

From www.fda.gov

Computed Descriptors

2D Structure
CID	9812759
IUPAC Name	zinc;dihydroxide
InChI	InChI=1S/2H2O.Zn/h2*1H2;/q;;+2/p-2
InChI Key	UGZADUVQMDAIAO-UHFFFAOYSA-L
Canonical SMILES	[OH-].[OH-].[Zn+2]
Molecular Formula	Zn(OH)2
Wikipedia	zinc hydroxide

From Pubchem

Computed Properties

Property Name	Property Value
Molecular Weight	99.394
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Complexity	0.0
CACTVS Substructure Key Fingerprint	A A A D c Q A A M A A A A A A C A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A C A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A = =
Topological Polar Surface Area	2.0
Monoisotopic Mass	97.935
Exact Mass	97.935
Compound Is Canonicalized	True
Formal Charge	0
Heavy Atom Count	3
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Isotope Atom Count	0
Covalently-Bonded Unit Count	3

From Pubchem

Toxicity Profile

Route of Exposure	Inhalation ; oral ; dermal
Mechanism of Toxicity	Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc.
Metabolism	Zinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces.
Toxicity Values	None
Lethal Dose	None
Carcinogenicity (IARC Classification)	No indication of carcinogenicity to humans (not listed by IARC).
Minimum Risk Level	Intermediate Oral: 0.3 mg/kg/day Chronic Oral: 0.3 mg/kg/day
Health Effects	Chronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (L49)
Treatment	Zinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage.
Reference	Vonk WI, Klomp LW: Role of transition metals in the pathogenesis of amyotrophic lateral sclerosis. Biochem Soc Trans. 2008 Dec;36(Pt 6):1322-8. doi: 10.1042/BST0361322.[19021549 ]

From T3DB

Taxonomic Classification

Kingdom	Inorganic compounds
Superclass	Mixed metal/non-metal compounds
Class	Transition metal oxoanionic compounds
Subclass	Transition metal hydroxides
Intermediate Tree Nodes	Not available
Direct Parent	Transition metal hydroxides
Alternative Parents	Inorganic salts Inorganic oxides Inorganic hydrides
Molecular Framework	Not available
Substituents	Transition metal hydroxide - Inorganic hydride - Inorganic oxide - Inorganic salt
Description	This compound belongs to the class of inorganic compounds known as transition metal hydroxides. These are inorganic compounds in which the largest oxoanion is hydroxide, and in which the heaviest atom not in an oxoanion is a transition metal.

From ClassyFire

Targets

Superoxide dismutase [Cu-Zn]

General Function:: Zinc ion binding
Specific Function:: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Gene Name:: SOD1
Uniprot ID:: P00441
Molecular Weight:: 15935.685 Da

References

Vonk WI, Klomp LW: Role of transition metals in the pathogenesis of amyotrophic lateral sclerosis. Biochem Soc Trans. 2008 Dec;36(Pt 6):1322-8. doi: 10.1042/BST0361322. [19021549 ]

From T3DB