Curcumin

Relevant Data

Food Additives Approved by WHO:

General Information

Chemical nameCurcumin
E No.E 100
INS.100
CAS number458-37-7
GroupNo
Component of the group Group III, Food colours with combined maximum limit (Group III)

From webgate.ec.europa.eu

Authorisation of the use of this additive in Food Additives

The additive is authorised to be used in the following category(ies):
category(ies) Individual restriction(s)/exception(s) footnote
  • Processed cheese (1.7.5)(legislation:232/2012, applicable as from 01/06/2013)
  • ML = 100 mg/kg , only flavoured processed cheese
  • 33 Maximum individually or for the combination of E 100, E 102, E 120, E 122, E 160e and E 161b
  • Fats and oils essentially free from water (excluding anhydrous milkfat) (2.1)(legislation:1129/2011, applicable as from 01/06/2013)
  • quantum satis , only fats
  • Other fat and oil emulsions including spreads as defined by Council Regulation (EC) No 1234/2007 and liquid emulsions (2.2.2)(legislation:1129/2011, applicable as from 01/06/2013)
  • quantum satis , excluding reduced fat butter
  • Jam, jellies and marmalades and sweetened chestnut puree as defined by Directive 2001/113/EC (4.2.5.2)(legislation:1129/2011, applicable as from 01/06/2013)
  • quantum satis , except chestnut puree
  • Other similar fruit or vegetable spreads (4.2.5.3)(legislation:1129/2011, applicable as from 01/06/2013)
  • quantum satis , except crème de pruneaux
  • Processed potato products (4.2.6)(legislation:1129/2011, applicable as from 01/06/2013)
  • quantum satis , only dried potato granules and flakes
  • Non-heat-treated processed meat (8.3.1)(legislation:1129/2011, applicable as from 01/06/2013)
  • ML = 20 mg/kg , only sausages

  • quantum satis , only pasturmas
  • Heat-treated processed meat (8.3.2)(legislation:1129/2011, applicable as from 01/06/2013)
  • ML = 20 mg/kg , only sausages, patés and terrines
  • Casings and coatings and decorations for meat (8.3.3)(legislation:1129/2011, applicable as from 01/06/2013)
  • quantum satis , only edible external coating of pasturmas
  • Processed fish and fisheries products including molluscs and crustaceans (9.2)(legislation:438/2013, applicable as from 03/06/2013)
  • ML = 250 , only precooked crustacean

  • ML = 100 , only smoked fish

  • ML = 100 , only fish paste and crustacean paste
  • 35 Maximum individually or for the combination of E 100, E 102, E 120, E 122, E 142, E 151, E 160e, E 161b

  • 36 Maximum individually or for the combination of E 100, 102, E 120, E 122, E 129, E 142, E 151, E 160e, E 161b

  • 37 Maximum individually or for the combination of E 100, E 102, E 120, E 151, E 160e
  • Aromatised wines (14.2.7.1)(legislation:1129/2011, applicable as from 01/06/2013)
  • ML = 100 mg/l , only americano, bitter vino
  • 26 In americano E 100, E 101, E 102, E 104, E 120, E 122, E 123, E 124 are authorised individually or in combination

  • 27 In bitter vino E 100, E 101, E 102, E 104, E 110, E 120, E 122, E 123, E 124, E 129 are authorised individually or in combination
  • Aromatised wine-based drinks (14.2.7.2)(legislation:1129/2011, applicable as from 01/06/2013)
  • ML = 100 mg/l , only bitter soda
  • 28 In bitter soda E 100, E 101, E 102, E 104, E 110, E 120, E 122, E 123, E 124, E 129 are authorised individually or in combination
  • Fruit and vegetable preparations excluding compote (4.2.4.1)(legislation:738/2013, applicable as from 20/08/2013)
  • ML = 50 mg/kg , only seawed-based fish roe analogues
  • Meat preparations as defined by Regulation (EC) No 853/2004 (8.2)(legislation:601/2014, applicable as from 25/06/2014)
  • ML = 20 mg/kg , only merguez type products, salsicha fresca, butifarra fresca, longaniza fresca and chorizo fresco

From webgate.ec.europa.eu

Targets

Target Details

Peroxisome proliferator-activated receptor gamma

General Function:
Zinc ion binding
Specific Function:
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).
Gene Name:
PPARG
Uniprot ID:
P37231
Molecular Weight:
57619.58 Da
Target Details

Vitamin D3 receptor

General Function:
Zinc ion binding
Specific Function:
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
Gene Name:
VDR
Uniprot ID:
P11473
Molecular Weight:
48288.64 Da
Target Details

Multidrug resistance-associated protein 5

General Function:
Organic anion transmembrane transporter activity
Specific Function:
Acts as a multispecific organic anion pump which can transport nucleotide analogs.
Gene Name:
ABCC5
Uniprot ID:
O15440
Molecular Weight:
160658.8 Da
Target Details

Carbonyl reductase [NADPH] 1

General Function:
Prostaglandin-e2 9-reductase activity
Specific Function:
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
Gene Name:
CBR1
Uniprot ID:
P16152
Molecular Weight:
30374.73 Da
Target Details

Glutathione S-transferase P

General Function:
S-nitrosoglutathione binding
Specific Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
Gene Name:
GSTP1
Uniprot ID:
P09211
Molecular Weight:
23355.625 Da

From T3DB