Polyethylene glycol

Relevant Data

Food Additives Approved in the United States

Food Additives Approved by WHO:

General Information

Chemical namePolyethylene glycol
E No.E 1521
INS.1521
CAS number25322-68-3
GroupNo

From webgate.ec.europa.eu

Authorisation of the use of this additive in Food Additives

The additive is authorised to be used in the following category(ies):
category(ies) Individual restriction(s)/exception(s) footnote
  • Table-Top Sweeteners in powder form (11.4.2)(legislation:1129/2011, applicable as from 01/06/2013)

  • Table-Top Sweeteners in tablets (11.4.3)(legislation:1129/2011, applicable as from 01/06/2013)
  • quantum satis
  • Food supplements supplied in a solid form including capsules and tablets and similar forms, excluding chewable forms (17.1)(legislation:1129/2011, applicable as from 01/06/2013)
  • ML = 10000 mg/kg , only in capsule and tablet form
  • There are no applications for this additive

From webgate.ec.europa.eu

Targets

Target Details

Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

General Function:
Zinc ion binding
Specific Function:
By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity and function.
Gene Name:
ENPP1
Uniprot ID:
P22413
Molecular Weight:
104923.58 Da

From T3DB