General Information

Chemical Names: 3-phytase: myo-inositol hexakisphosphate 3-phosphohydrolase (EC 3.1.3.8)
Functional Class: Food Additives
ENZYME_PREPARATION

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Evaluations

Evaluation year: 2012
ADI: NOT SPECIFIED
Specs Code: N
Comments: Comparing the conservative exposure estimate with the no-observed-adverse-effect level (NOAEL) from the 13-week study of oral toxicity in rats, the margin of exposure is approximately 250. The Committee allocated an ADI “not specified”b for 3-phytase enzyme preparation from A. niger expressed in A. niger used in the applications specified and in accordance with good manufacturing practice.
Report: TRS 974 JECFA 76
Tox Monograph: FAS 67 JECFA 76
Specification: Compendium of food additive specifications. FAO JECFA Monographs 13, 2012

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