POLYETHYLENE GLYCOLS
Relevant Data
Food Additives Approved in the United States
Food Additives Approved by European Union:
General Information
| Synonyms: | MACROGOL, PEG |
| Chemical Names: | alpha-HYDRO-omega-HYDROXYPOLY(OXY-1,2-ETHANEDIOL) |
| CAS number: | 25322-68-3 |
| INS: | 1521 |
| Functional Class: |
Food Additives ADJUVANT CARRIER_SOLVENT |
From apps.who.int
Evaluations
| Evaluation year: | 1979 |
| ADI: | 0-10 mg/kg bw |
| Meeting: | 23 |
| Specs Code: | R (1987) |
| Report: | TRS 648-JECFA 23/17 |
| Tox Monograph: | FAS 14-JECFA 23/76 |
| Specification: | COMPENDIUM ADDENDUM 11/FNP 52 Add. 11/89 (METALS LIMITS) (2003). R; FAO JECFA Monographs 1 vol.3/65 |
From apps.who.int
Targets
- General Function:
- Zinc ion binding
- Specific Function:
- By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity and function.
- Gene Name:
- ENPP1
- Uniprot ID:
- P22413
- Molecular Weight:
- 104923.58 Da
From T3DB