Relevant Data

Food Additives Approved in the United States

Food Additives Approved by European Union:

  • Sulphur dioxide [show]

General Information

CAS number: 7446-09-5
INS:

220

Functional Class: Food Additives
PRESERVATIVE
ANTIOXIDANT
FLOUR_TREATMENT_AGENT

From apps.who.int


Evaluations

Evaluation year: 1998
ADI: 0-0.7 mg/kg bw
Meeting: 49
Specs Code: R (1997)
Comments: Group ADI, expressed as sulfur dioxide, for calcium hydrogen sulfite, calcium metabisulfite, calcium sulfite, potassium hydrogen sulfite, potassium metabisulfite, potassium sulfite, sodium hydrogen sulfite, sodium metabisulfite, sodium sulfite, sodium thiosulfate, and sulfur dioxide
Report: TRS 891-JECFA 51/30
Tox Monograph: FAS 42-JECFA 51/95
Specification: COMPENDIUM ADDENDUM 6/FNP 52 Add.6/159. R; FAO JECFA Monographs 1 vol.3/465

From apps.who.int



GSFA Provisions for SULFUR DIOXIDE

Number Food Category Max Level Notes
14.2.7

Aromatized alcoholic beverages (e.g. beer, wine and spirituous cooler-type beverages, low alcoholic refreshers)

250 mg/kg Note 44
14.2.1

Beer and malt beverages

50 mg/kg Note 44
11.2

Brown sugar excluding products of food category 11.1.3

40 mg/kg Note 44
04.1.2.7

Candied fruit

100 mg/kg Note 44
04.2.2.4

Canned or bottled (pasteurized) or retort pouch vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), and seaweeds

50 mg/kg Note 44
14.2.2

Cider and perry

200 mg/kg Note 44
14.1.2.3

Concentrates for fruit juice

50 mg/kg Note 127,Note 44,Note 122
14.1.3.3

Concentrates for fruit nectar

50 mg/kg Note 127,Note 44,Note 122
14.1.2.4

Concentrates for vegetable juice

50 mg/kg Note 127,Note 44,Note 122
14.1.3.4

Concentrates for vegetable nectar

50 mg/kg Note 127,Note 44,Note 122
09.2.4.2

Cooked mollusks, crustaceans, and echinoderms

150 mg/kg Note 44
14.2.6

Distilled spirituous beverages containing more than 15% alcohol

200 mg/kg Note 44
04.1.2.2

Dried fruit

1,000 mg/kg Note 135,Note 218,Note 44
04.2.2.2

Dried vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweeds, and nuts and seeds

500 mg/kg Note 44,Note 105
04.1.2.10

Fermented fruit products

100 mg/kg Note 44
04.2.2.7

Fermented vegetable (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera) and seaweed products, excluding fermented soybean products of food categories 06.8.6, 06.8.7, 12.9.1, 12.9.2.1 and 12.9.2.3

500 mg/kg Note 44
07.2

Fine bakery wares (sweet, salty, savoury) and mixes

50 mg/kg Note 44
06.2.1

Flours

200 mg/kg Note 44
09.1.2

Fresh mollusks, crustaceans, and echinoderms

100 mg/kg Note XS315,Note 44,Note XS312,Note 390
09.2.1

Frozen fish, fish fillets, and fish products, including mollusks, crustaceans, and echinoderms

100 mg/kg Note XS36,Note 392,Note XS191,Note 44,Note XS312,Note 139,Note XS315,Note XS165,Note XS190,Note 19
04.1.2.1

Frozen fruit

500 mg/kg Note 155,Note 44
04.2.2.1

Frozen vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweeds, and nuts and seeds

50 mg/kg Note 136,Note 44,Note 137,Note 76
04.1.2.11

Fruit fillings for pastries

100 mg/kg Note 44
04.1.2.3

Fruit in vinegar, oil, or brine

100 mg/kg Note 44
14.1.2.1

Fruit juice

50 mg/kg Note 122,Note 44
14.1.3.1

Fruit nectar

50 mg/kg Note 122,Note 44
04.1.2.8

Fruit preparations, including pulp, purees, fruit toppings and coconut milk

100 mg/kg Note 206,Note 44
04.1.2.9

Fruit-based desserts, including fruit-flavoured water-based desserts

100 mg/kg Note 44
09.4

Fully preserved, including canned or fermented fish and fish products, including mollusks, crustaceans, and echinoderms

150 mg/kg Note 140,Note 44
14.2.3

Grape wines

350 mg/kg Note 103,Note 44
12.2.1

Herbs and spices

150 mg/kg Note 44
04.1.2.5

Jams, jellies, marmelades

100 mg/kg Note 44
14.2.5

Mead

200 mg/kg Note 44
12.4

Mustards

250 mg/kg Note 106,Note 44
11.4

Other sugars and syrups (e.g. xylose, maple syrup, sugar toppings)

40 mg/kg Note 44
04.2.1.3

Peeled, cut or shredded fresh vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweeds, and nuts and seeds

50 mg/kg Note 136,Note 44,Note 76
11.1.5

Plantation or mill white sugar

70 mg/kg Note 44
11.1.2

Powdered sugar, powdered dextrose

15 mg/kg Note 44
06.4.3

Pre-cooked pastas and noodles and like products

20 mg/kg Note 44
12.6

Sauces and like products

300 mg/kg Note 44
12.2.2

Seasonings and condiments

200 mg/kg Note 44
09.2.5

Smoked, dried, fermented, and/or salted fish and fish products, including mollusks, crustaceans, and echinoderms

30 mg/kg Note XS311,Note 44
15.1

Snacks - potato, cereal, flour or starch based (from roots and tubers, pulses and legumes)

50 mg/kg Note 44
11.1.3

Soft white sugar, soft brown sugar, glucose syrup, dried glucose syrup, raw cane sugar

20 mg/kg Note 44,Note 111
06.2.2

Starches

50 mg/kg Note 44
11.3

Sugar solutions and syrups, also (partially) inverted, including treacle and molasses, excluding products of food category 11.1.3

70 mg/kg Note 44
04.1.1.2

Surface-treated fresh fruit

30 mg/kg Note 204,Note 44
04.2.2.6

Vegetable (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweed, and nut and seed pulps and preparations (e.g. vegetable desserts and sauces, candied vegetables) other than food category 04.2.2.5

300 mg/kg Note 205,Note 44
04.2.2.5

Vegetable (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweed, and nut and seed purees and spreads (e.g., peanut butter)

500 mg/kg Note 38,Note 44
14.1.2.2

Vegetable juice

50 mg/kg Note 122,Note 44
14.1.3.2

Vegetable nectar

50 mg/kg Note 122,Note 44
04.2.2.3

Vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), and seaweeds in vinegar, oil, brine, or soybean sauce

100 mg/kg Note 44
12.3

Vinegars

100 mg/kg Note 44
14.1.4

Water-based flavoured drinks, including "sport," "energy," or "electrolyte" drinks and particulated drinks

70 mg/kg Note 127,Note 44,Note 143
11.1.1

White sugar, dextrose anhydrous, dextrose monohydrate, fructose

15 mg/kg Note 44
14.2.4

Wines (other than grape)

200 mg/kg Note 44

From www.fao.org


Computed Descriptors

Download SDF
2D Structure
CID1119
IUPAC Namesulfur dioxide
InChIInChI=1S/O2S/c1-3-2
InChI KeyRAHZWNYVWXNFOC-UHFFFAOYSA-N
Canonical SMILESO=S=O
Molecular FormulaSO2
Wikipediasulfur dioxide

From Pubchem


Computed Properties

Property Name Property Value
Molecular Weight64.058
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Complexity18.3
CACTVS Substructure Key Fingerprint A A A D c Q A A M A B A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A D A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A = =
Topological Polar Surface Area35.1
Monoisotopic Mass63.962
Exact Mass63.962
XLogP3None
XLogP3-AA0.1
Compound Is CanonicalizedTrue
Formal Charge0
Heavy Atom Count3
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Isotope Atom Count0
Covalently-Bonded Unit Count1

From Pubchem


Food Additives Biosynthesis/Degradation


ADMET Predicted Profile --- Classification

Model Result Probability
Absorption
Blood-Brain BarrierBBB+0.9825
Human Intestinal AbsorptionHIA+0.9897
Caco-2 PermeabilityCaco2-0.5062
P-glycoprotein SubstrateNon-substrate0.9191
P-glycoprotein InhibitorNon-inhibitor0.9291
Non-inhibitor0.9969
Renal Organic Cation TransporterNon-inhibitor0.9445
Distribution
Subcellular localizationMitochondria0.4289
Metabolism
CYP450 2C9 SubstrateNon-substrate0.8199
CYP450 2D6 SubstrateNon-substrate0.8445
CYP450 3A4 SubstrateNon-substrate0.7826
CYP450 1A2 InhibitorNon-inhibitor0.7569
CYP450 2C9 InhibitorNon-inhibitor0.7626
CYP450 2D6 InhibitorNon-inhibitor0.9150
CYP450 2C19 InhibitorNon-inhibitor0.7961
CYP450 3A4 InhibitorNon-inhibitor0.9862
CYP Inhibitory PromiscuityLow CYP Inhibitory Promiscuity0.8904
Excretion
Toxicity
Human Ether-a-go-go-Related Gene InhibitionWeak inhibitor0.8588
Non-inhibitor0.9656
AMES ToxicityNon AMES toxic0.5706
CarcinogensCarcinogens 0.6787
Fish ToxicityLow FHMT0.8428
Tetrahymena Pyriformis ToxicityHigh TPT0.5000
Honey Bee ToxicityHigh HBT0.8037
BiodegradationReady biodegradable0.8007
Acute Oral ToxicityII0.4449
Carcinogenicity (Three-class)Non-required0.6371

From admetSAR


ADMET Predicted Profile --- Regression

Model Value Unit
Absorption
Aqueous solubility-0.6777LogS
Caco-2 Permeability1.0950LogPapp, cm/s
Distribution
Metabolism
Excretion
Toxicity
Rat Acute Toxicity2.5276LD50, mol/kg
Fish Toxicity1.9674pLC50, mg/L
Tetrahymena Pyriformis Toxicity-0.0623pIGC50, ug/L

From admetSAR


Taxonomic Classification

KingdomInorganic compounds
SuperclassHomogeneous non-metal compounds
ClassOther non-metal organides
SubclassOther non-metal oxides
Intermediate Tree NodesNot available
Direct ParentOther non-metal oxides
Alternative Parents
Molecular FrameworkNot available
SubstituentsOther non-metal oxide - Inorganic oxide
DescriptionThis compound belongs to the class of inorganic compounds known as other non-metal oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen belongs to the class of 'other non-metals'.

From ClassyFire