Main Reaction: tetrahydrofolate >> 5’,10’-methylene THF

Reference: PubMed ID: 26616421
Authors: Ghodke-Puranik Y, Puranik AS, Shintre P, Joshi K, Patwardhan B, Lamba J, Niewold TB, Chopra A
Title: Folate metabolic pathway single nucleotide polymorphisms: a predictive pharmacogenetic marker of methotrexate response in Indian (Asian) patients with rheumatoid arthritis.
Published: 2015 Dec

tetrahydrofolate --> 5’,10’-methylene THF