Inositol-3-phosphate synthase 1

NameInositol-3-phosphate synthase 1
Synonyms
  • 5.5.1.4
  • hINO1
  • hIPS
  • INO1
  • IPS 1
  • MI-1-P synthase
  • MIP synthase
  • Myo-inositol 1-phosphate synthase
  • Myo-inositol 1-phosphate synthase A1
Gene NameISYNA1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009417|Inositol-3-phosphate synthase 1
MEAAAQFFVESPDVVYGPEAIEAQYEYRTTRVSREGGVLKVHPTSTRFTFRTARQVPRLG
VMLVGWGGNNGSTLTAAVLANRLRLSWPTRSGRKEANYYGSLTQAGTVSLGLDAEGQEVF
VPFSAVLPMVAPNDLVFDGWDISSLNLAEAMRRAKVLDWGLQEQLWPHMEALRPRPSVYI
PEFIAANQSARADNLIPGSRAQQLEQIRRDIRDFRSSAGLDKVIVLWTANTERFCEVIPG
LNDTAENLLRTIELGLEVSPSTLFAVASILEGCAFLNGSPQNTLVPGALELAWQHRVFVG
GDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNHLGNNDGENLSAPLQFRSKEVSKSNVV
DDMVQSNPVLYTPGEEPDHCVVIKYVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDS
LLAAPIMLDLALLTELCQRVSFCTDMDPEPQTFHPVLSLLSFLFKAPLVPPGSPVVNALF
RQRSCIENILRACVGLPPQNHMLLEHKMERPGPSLKRVGPVAATYPMLNKKGPVPAATNG
CTGDANGHLQEEPPMPTT
Number of residues558
Molecular Weight61067.285
Theoretical pINone
GO Classification
Functions
  • inositol-3-phosphate synthase activity
Processes
  • small molecule metabolic process
  • phospholipid biosynthetic process
  • inositol biosynthetic process
  • inositol phosphate metabolic process
Components
  • cytosol
General FunctionInositol-3-phosphate synthase activity
Specific FunctionKey enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ9NPH2
UniProtKB Entry NameINO1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013145|Inositol-3-phosphate synthase 1 (ISYNA1)
ATGGAGGCCGCCGCCCAGTTCTTCGTCGAGAGCCCGGACGTGGTCTACGGCCCCGAGGCC
ATCGAGGCGCAATACGAGTACCGGACGACGCGCGTCAGCCGCGAGGGTGGCGTTCTCAAG
GAGGCCAACTACTACGGCTCGCTGACTCAGGCGGGCACCGTGAGCCTGGGCCTGGACGCC
GAGGGCCAGGAGGTGTTCGTACCCTTCAGCGCGGTGCTGCCCATGGTGGCGCCCAACGAC
CTCGTGTTCGATGGCTGGGACATCTCGTCGCTGAACCTGGCCGAGGCGATGCGGCGCGCG
AAGGTGCTGGACTGGGGGCTGCAGGAGCAACTGTGGCCGCACATGGAGGCCCTGCGGCCC
CGGCCTTCTGTTTACATCCCCGAATTCATCGCGGCCAACCAGAGCGCGCGCGCGGACAAC
CTCATCCCAGGCTCGCGTGCGCAGCAGCTGGAGCAGATCCGCAGGGACATCCGAGACTTC
CGGTCTAGCGCGGGGCTGGACAAAGTCATAGTGCTGTGGACGGCGAACACGGAGCGCTTC
TGTGAGGTGATTCCAGGCCTCAACGACACAGCCGAGAACCTGCTGCGCACCATTGAGCTC
GGTCTGGAGGTGTCGCCCTCCACGCTCTTCGCCGTGGCCAGCATCCTGGAGGGCTGTGCC
TTCCTCAATGGGTCTCCGCAGAACACCCTGGTGCCCGGAGCTCTTGAGCTCGCGTGGCAG
CACCGGGTTTTTGTGGGCGGAGATGACTTCAAGTCAGGCCAGACCAAAGTCAAGTCCGTG
CTTGTGGACTTCCTCATTGGCTCCGGCCTCAAGACCATGTCCATCGTGAGTTACAACCAC
CTGGGCAACAACGATGGGGAGAACCTATCGGCGCCATTGCAGTTCCGCTCTAAGGAGGTG
TCCAAGAGCAACGTGGTGGACGACATGGTGCAGAGCAACCCAGTGCTCTATACGCCCGGC
GAAGAGCCTGACCACTGCGTGGTCATCAAGTATGTGCCGTACGTGGGTGACAGCAAGCGC
GCGCTGGATGAGTATACCTCGGAGCTGATGCTGGGCGGAACCAACACACTGGTGCTGCAC
AACACGTGTGAGGACTCGCTGCTGGCCGCACCCATCATGCTGGACCTAGCGCTGCTGACC
GAGCTGTGCCAGCGCGTGAGCTTCTGCACTGACATGGACCCCGAGCCGCAGACCTTCCAC
CCCGTGCTGTCCCTGCTCAGCTTCCTCTTCAAGGCGCCACTAGTGCCGCCCGGCAGCCCG
GTGGTCAATGCGCTTTTCCGCCAGCGCAGCTGCATCGAGAACATCCTCAGGGCCTGCGTG
GGGCTCCCGCCACAGAACCACATGCTCCTGGAACACAAAATGGAGCGCCCAGGGCCCAGC
CTCAAGCGAGTTGGACCCGTGGCTGCCACCTACCCTATGTTGAACAAGAAAGGACCGGTA
CCCGCTGCCACCAATGGCTGCACCGGTGATGCCAATGGGCATCTGCAAGAGGAGCCCCCA
ATGCCCACCACCTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:29821
Chromosome Location19
LocusNone
References
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