Alpha-synuclein

NameAlpha-synuclein
Synonyms
  • NACP
  • Non-A beta component of AD amyloid
  • Non-A4 component of amyloid precursor
  • PARK1
Gene NameSNCA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001750|Alpha-synuclein
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK
EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP
DNEAYEMPSEEGYQDYEPEA
Number of residues140
Molecular Weight14460.155
Theoretical pI4.37
GO Classification
Functions
  • calcium ion binding
  • alpha-tubulin binding
  • Hsp70 protein binding
  • phosphoprotein binding
  • kinesin binding
  • dynein binding
  • oxidoreductase activity
  • cysteine-type endopeptidase inhibitor activity involved in apoptotic process
  • zinc ion binding
  • phospholipid binding
  • tau protein binding
  • histone binding
  • ferrous iron binding
  • copper ion binding
  • magnesium ion binding
  • identical protein binding
  • transcription regulatory region DNA binding
Processes
  • cellular response to copper ion
  • cellular response to fibroblast growth factor stimulus
  • negative regulation of microtubule polymerization
  • phospholipid metabolic process
  • negative regulation of exocytosis
  • synapse organization
  • negative regulation of thrombin receptor signaling pathway
  • regulation of locomotion
  • behavioral response to cocaine
  • response to magnesium ion
  • cellular protein metabolic process
  • negative regulation of histone acetylation
  • aging
  • response to interleukin-1
  • protein destabilization
  • negative regulation of transporter activity
  • positive regulation of endocytosis
  • negative regulation of neuron apoptotic process
  • negative regulation of platelet-derived growth factor receptor signaling pathway
  • neutral lipid metabolic process
  • oxidation-reduction process
  • dopamine biosynthetic process
  • negative regulation of serotonin uptake
  • response to drug
  • activation of cysteine-type endopeptidase activity involved in apoptotic process
  • positive regulation of glutathione peroxidase activity
  • adult locomotory behavior
  • negative regulation of apoptotic process
  • dopamine uptake involved in synaptic transmission
  • regulation of synaptic vesicle recycling
  • positive regulation of hydrogen peroxide catabolic process
  • response to interferon-gamma
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • cellular response to epinephrine stimulus
  • extracellular fibril organization
  • positive regulation of neurotransmitter secretion
  • excitatory postsynaptic potential
  • regulation of acyl-CoA biosynthetic process
  • positive regulation of peptidyl-serine phosphorylation
  • positive regulation of inositol phosphate biosynthetic process
  • regulation of dopamine secretion
  • mitochondrial membrane organization
  • negative regulation of dopamine metabolic process
  • regulation of glutamate secretion
  • cellular response to oxidative stress
  • positive regulation of release of sequestered calcium ion into cytosol
  • mitochondrial ATP synthesis coupled electron transport
  • positive regulation of protein serine/threonine kinase activity
  • negative regulation of dopamine uptake involved in synaptic transmission
  • synaptic vesicle endocytosis
  • regulation of phospholipase activity
  • positive regulation of apoptotic process
  • response to lipopolysaccharide
  • response to iron(II) ion
  • negative regulation of mitochondrial electron transport, NADH to ubiquinone
  • regulation of macrophage activation
  • regulation of long-term neuronal synaptic plasticity
  • regulation of reactive oxygen species biosynthetic process
  • receptor internalization
  • negative regulation of transcription from RNA polymerase II promoter
  • microglial cell activation
  • negative regulation of protein phosphorylation
  • negative regulation of monooxygenase activity
  • fatty acid metabolic process
  • positive regulation of receptor recycling
  • long-term synaptic potentiation
  • negative regulation of norepinephrine uptake
Components
  • extracellular region
  • synaptic vesicle
  • nuclear outer membrane
  • nucleus
  • cell junction
  • cell cortex
  • fibril
  • Golgi apparatus
  • plasma membrane
  • terminal bouton
  • cytosol
  • perinuclear region of cytoplasm
  • cytoplasm
  • extracellular space
  • cytoplasmic vesicle membrane
  • mitochondrion
  • lysosome
  • axon
  • membrane
  • inclusion body
  • ribosome
  • growth cone
  • actin cytoskeleton
  • rough endoplasmic reticulum
General FunctionNone
Specific FunctionNone
Transmembrane Regions
GenBank Protein ID437365
UniProtKB IDP37840
UniProtKB Entry NameSYUA_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0021281|Alpha-synuclein (SNCA)
ATGGATGTATTCATGAAAGGACTTTCAAAGGCCAAGGAGGGAGTTGTGGCTGCTGCTGAG
AAAACCAAACAGGGTGTGGCAGAAGCAGCAGGAAAGACAAAAGAGGGTGTTCTCTATGTA
GGCTCCAAAACCAAGGAGGGAGTGGTGCATGGTGTGGCAACAGTGGCTGAGAAGACCAAA
GAGCAAGTGACAAATGTTGGAGGAGCAGTGGTGACGGGTGTGACAGCAGTAGCCCAGAAG
ACAGTGGAGGGAGCAGGGAGCATTGCAGCAGCCACTGGCTTTGTCAAAAAGGACCAGTTG
GGCAAGAATGAAGAAGGAGCCCCACAGGAAGGAATTCTGGAAGATATGCCTGTGGATCCT
GACAATGAGGCTTATGAAATGCCTTCTGAGGAAGGGTATCAAGACTACGAACCTGAAGCC
TAA
GenBank Gene IDL08850
GeneCard IDNone
GenAtlas IDSNCA
HGNC IDHGNC:11138
Chromosome LocationNone
Locus4q21
References
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